30,668 research outputs found
Biological implications of a discrete mathematical model for collagen deposition and alignment in dermal wound repair
We deveiop a novel mathematical model for collagen deposition and alignment during dermal wound healing. We focus on the interactions between fibroblasts, modelled as discrete entities, and a continuous extracellular matrix composed of collagen and a fibrin based blood clot. There are four basic interactions assumed in the model: fibroblasts orient the collagen matrix, fibroblasts produce and degrade collagen and fibrin and the matrix directs the fibroblasts and determines the speed of the cells. Several factors which influence the alignment of collagen are examined and related to current anti-scarring therapies using transforming growth factor ß. The most influential of these factors are cell speed and, more importantly for wound healing, the influx of fibroblasts from surrounding tissue
Stress and large-scale spatial structures in dense, driven granular flows
We study the appearance of large-scale dynamical heterogeneities in a
simplified model of a driven, dissipative granular system. Simulations of
steady-state gravity-driven flows of inelastically colliding hard disks show
the formation of large-scale linear structures of particles with a high
collision frequency. These chains can be shown to carry much of the collisional
stress in the system due to a dynamical correlation that develops between the
momentum transfer and time between collisions in these "frequently-colliding"
particles. The lifetime of these dynamical stress heterogeneities is seen to
grow as the flow velocity decreases towards jamming, leading to slowly decaying
stress correlations reminiscent of the slow dynamics observed in supercooled
liquids.Comment: 8 pages, 6 figure
On a model mechanism for the spatial patterning of teeth primordia in the Alligator
We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator,Alligator mississippiensis. Detailed embryological studies by Westergaard & Ferguson (1986, 1987, 1990) show that jaw growth plays a crucial role in the developmental patterning of the tooth initiation process. Based on biological data we develop a reaction-diffusion mechanism, which crucially includes domain growth. The model can reproduce the spatial pattern development of the first seven teeth primordia in the lower half jaw ofA. mississippiensis. The results for the precise spatio-temporal sequence compare well with detailed developmental experiments
Structural templating as a route to improved photovoltaic performance in copper phthalocyanine/fullerene (C60) heterojunctions
We have developed a method to improve the short circuit current density in copper phthalocyanine (CuPc)/fullerene (C60) organic solar cells by ~60% by modifying the CuPc crystal orientation through use of a molecular interlayer to maximize charge transport in the direction between the two electrodes. Powder x-ray diffraction and electronic absorption spectroscopy show that a thin 3,4,9,10-perylenetetracarboxylic dianhydride interlayer before CuPc growth templates the CuPc film structure, forcing the molecules to lie flat with respect to the substrate surface, although the intrastack orientation is unaffected. This modified stacking configuration facilitates charge transport and improves charge collection
Spin gating electrical current
We use an aluminium single electron transistor with a magnetic gate to
directly quantify the chemical potential anisotropy of GaMnAs materials.
Uniaxial and cubic contributions to the chemical potential anisotropy are
determined from field rotation experiments. In performing magnetic field sweeps
we observe additional isotropic magnetic field dependence of the chemical
potential which shows a non-monotonic behavior. The observed effects are
explained by calculations based on the kinetic
exchange model of ferromagnetism in GaMnAs. Our device inverts the conventional
approach for constructing spin transistors: instead of spin-transport
controlled by ordinary gates we spin-gate ordinary charge transport.Comment: 5 pages, 4 figure
Searching for additional heating - [OII] emission in the diffuse ionized gas of NGC891, NGC4631 and NGC3079
We present spectroscopic data of ionized gas in the disk--halo regions of
three edge-on galaxies, NGC 891, NGC 4631 and NGC 3079, covering a wavelength
range from [\ion{O}{2}] 3727\AA to [\ion{S}{2}] 6716.4\AA.
The inclusion of the [\ion{O}{2}] emission provides new constraints on the
properties of the diffuse ionized gas (DIG), in particular, the origin of the
observed spatial variations in the line intensity ratios. We used three
different methods to derive electron temperatures, abundances and ionization
fractions along the slit. The increase in the [\ion{O}{2}]/H line ratio
towards the halo in all three galaxies requires an increase either in electron
temperature or in oxygen abundance. Keeping the oxygen abundance constant
yields the most reasonable results for temperature, abundances, and ionization
fractions. Since a constant oxygen abundance seems to require an increase in
temperature towards the halo, we conclude that gradients in the electron
temperature play a significant role in the observed variations in the optical
line ratios from extraplanar DIG in these three spiral galaxies.Comment: 43 pages, 29 figure
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