Rural vs. Urban Health Disparities

Introduction and Background Individuals in rural areas do not have the same access to health care as individuals who live in urban areas. Individuals who live in rural areas tend to not get the care that they need due to income and location. Purpose Statement Healthcare differs for those who live in rural versus urban populations. How can the intervention of telehealth help to decrease the health disparities for individuals who live in rural communities? Literature Review We searched the phrases “rural and urban” and “health disparities” in google scholar and restricted the search to articles that were published from 2018 to now and we narrowed it down to 3 articles. For the two articles that included our intervention of telehealth we did a Google Scholar advanced search and used the keywords “telehealth” and “health disparities” and filtered the search to where the most recent would be shown and we narrowed it down to 2 articles. Findings The research that we collected strongly suggests that there are health disparities among rural areas compared to urban areas, meaning that rural areas do not have as good of access to adequate health care. The intervention of telehealth however could help improve the health disparities for those in rural areas. Conclusions Rural areas do not have as good of access to healthcare as those who live in urban areas. Our research gave a variety of different examples of how rural areas have a disadvantage when it comes to the quality of healthcare individuals receive. Telehealth can help to decrease these health disparities and improve the quality of care that individuals in rural areas receive

Mock Galaxy Surveys for HST and JWST from the IllustrisTNG Simulations

We present and analyze a series of synthetic galaxy survey fields based on the IllustrisTNG Simulation suite. With the Illustris public data release and JupyterLab service, we generated a set of twelve lightcone catalogs covering areas from 5 to 365 square arcminutes, similar to several JWST Cycle 1 programs, including JADES, CEERS, PRIMER, and NGDEEP. From these catalogs, we queried the public API to generate simple mock images in a series of broadband filters used by JWST-NIRCam and the Hubble Space Telescope cameras. This procedure generates wide-area simulated mosaic images that can support investigating the predicted evolution of galaxies alongside real data. Using these mocks, we demonstrate a few simple science cases, including morphological evolution and close pair selection. We publicly release the catalogs and mock images through MAST, along with the code used to generate these projects, so that the astrophysics community can make use of these products in their scientific analyses of JWST deep field observations.Comment: Accepted to MNRA

The masses of Local Group dwarf spheroidal galaxies: The death of the universal mass profile

We investigate the claim that all dwarf spheroidal galaxies (dSphs) reside within halos that share a common, universal mass profile as has been derived for dSphs of the Galaxy. By folding in kinematic information for 25 Andromeda dSphs, more than doubling the previous sample size, we find that a singular mass profile can not be found to fit all the observations well. Further, the best-fit dark matter density profile measured for solely the Milky Way dSphs is marginally discrepant (at just beyond the 1 sigma level) with that of the Andromeda dSphs, where a profile with lower maximum circular velocity, and hence mass, is preferred. The agreement is significantly better when three extreme Andromeda outliers, And XIX, XXI and XXV, all of which have large half-light radii (>600pc) and low velocity dispersions (sigma_v < 5km/s) are omitted from the sample. We argue that the unusual properties of these outliers are likely caused by tidal interactions with the host galaxy.Comment: ApJ in press, 16 pages, 7 figures. Updated to address referee comment

A kinematic study of the Andromeda dwarf spheroidal system

We present a homogeneous kinematic analysis of red giant branch stars within 18 of the 28 Andromeda dwarf spheroidal (dSph) galaxies, obtained using the Keck I LRIS and Keck II DEIMOS spectrographs. Based on their g-i colors (taken with the CFHT MegaCam imager), physical positions on the sky, and radial velocities, we assign probabilities of dSph membership to each observed star. Using this information, the velocity dispersions, central masses and central densities of the dark matter halos are calculated for these objects, and compared with the properties of the Milky Way dSph population. We also measure the average metallicity ([Fe/H]) from the co-added spectra of member stars for each M31 dSph and find that they are consistent with the trend of decreasing [Fe/H] with luminosity observed in the Milky Way population. We find that three of our studied M31 dSphs appear as significant outliers in terms of their central velocity dispersion, And XIX, XXI and XXV, all of which have large half-light radii (>700 pc) and low velocity dispersions (sigma_v<5 km/s). In addition, And XXV has a mass-to-light ratio within its half-light radius of just [M/L]_{half}=10.3^{+7.0}_{-6.7}, making it consistent with a simple stellar system with no appreciable dark matter component within its 1 sigma uncertainties. We suggest that the structure of the dark matter halos of these outliers have been significantly altered by tides.Comment: 41 pages, 23 figures. Accepted for publication in Ap

An 8.22 Mb Assembly and Annotation of the Alpaca (Vicugna pacos) Y Chromosome.

The unique evolutionary dynamics and complex structure make the Y chromosome the most diverse and least understood region in the mammalian genome, despite its undisputable role in sex determination, development, and male fertility. Here we present the first contig-level annotated draft assembly for the alpaca (Vicugna pacos) Y chromosome based on hybrid assembly of short- and long-read sequence data of flow-sorted Y. The latter was also used for cDNA selection providing Y-enriched testis transcriptome for annotation. The final assembly of 8.22 Mb comprised 4.5 Mb of male specific Y (MSY) and 3.7 Mb of the pseudoautosomal region. In MSY, we annotated 15 X-degenerate genes and two novel transcripts, but no transposed sequences. Two MSY genes, HSFY and RBMY, are multicopy. The pseudoautosomal boundary is located between SHROOM2 and HSFY. Comparative analysis shows that the small and cytogenetically distinct alpaca Y shares most of MSY sequences with the larger dromedary and Bactrian camel Y chromosomes. Most of alpaca X-degenerate genes are also shared with other mammalian MSYs, though WWC3Y is Y-specific only in alpaca/camels and the horse. The partial alpaca Y assembly is a starting point for further expansion and will have applications in the study of camelid populations and male biology

An 8.22 Mb Assembly and Annotation of the Alpaca (Vicugna pacos) Y Chromosome.

The unique evolutionary dynamics and complex structure make the Y chromosome the most diverse and least understood region in the mammalian genome, despite its undisputable role in sex determination, development, and male fertility. Here we present the first contig-level annotated draft assembly for the alpaca (Vicugna pacos) Y chromosome based on hybrid assembly of short- and long-read sequence data of flow-sorted Y. The latter was also used for cDNA selection providing Y-enriched testis transcriptome for annotation. The final assembly of 8.22 Mb comprised 4.5 Mb of male specific Y (MSY) and 3.7 Mb of the pseudoautosomal region. In MSY, we annotated 15 X-degenerate genes and two novel transcripts, but no transposed sequences. Two MSY genes, HSFY and RBMY, are multicopy. The pseudoautosomal boundary is located between SHROOM2 and HSFY. Comparative analysis shows that the small and cytogenetically distinct alpaca Y shares most of MSY sequences with the larger dromedary and Bactrian camel Y chromosomes. Most of alpaca X-degenerate genes are also shared with other mammalian MSYs, though WWC3Y is Y-specific only in alpaca/camels and the horse. The partial alpaca Y assembly is a starting point for further expansion and will have applications in the study of camelid populations and male biology

The Program of Gene Transcription for a Single Differentiating Cell Type During Sporulation in \u3cem\u3eBacillus subtilis\u3c/em\u3e

Asymmetric division during sporulation by Bacillus subtilis generates a mother cell that undergoes a 5-h program of differentiation. The program is governed by a hierarchical cascade consisting of the transcription factors: σE, σK, GerE, GerR, and SpoIIID. The program consists of the activation and repression of 383 genes. The σE factor turns on 262 genes, including those for GerR and SpoIIID. These DNA-binding proteins downregulate almost half of the genes in the σE regulon. In addition, SpoIIID turns on ten genes, including genes involved in the appearance of σK. Next, σK activates 75 additional genes, including that for GerE. This DNA-binding protein, in turn, represses half of the genes that had been activated by σK while switching on a final set of 36 genes. Evidence is presented that repression and activation contribute to proper morphogenesis. The program of gene expression is driven forward by its hierarchical organization and by the repressive effects of the DNA-binding proteins. The logic of the program is that of a linked series of feed-forward loops, which generate successive pulses of gene transcription. Similar regulatory circuits could be a common feature of other systems of cellular differentiation

The Program of Gene Transcription for a Single Differentiating Cell Type during Sporulation in Bacillus subtilis

Asymmetric division during sporulation by Bacillus subtilis generates a mother cell that undergoes a 5-h program of differentiation. The program is governed by a hierarchical cascade consisting of the transcription factors: σ(E), σ(K), GerE, GerR, and SpoIIID. The program consists of the activation and repression of 383 genes. The σ(E) factor turns on 262 genes, including those for GerR and SpoIIID. These DNA-binding proteins downregulate almost half of the genes in the σ(E) regulon. In addition, SpoIIID turns on ten genes, including genes involved in the appearance of σ(K) (.) Next, σ(K) activates 75 additional genes, including that for GerE. This DNA-binding protein, in turn, represses half of the genes that had been activated by σ(K) while switching on a final set of 36 genes. Evidence is presented that repression and activation contribute to proper morphogenesis. The program of gene expression is driven forward by its hierarchical organization and by the repressive effects of the DNA-binding proteins. The logic of the program is that of a linked series of feed-forward loops, which generate successive pulses of gene transcription. Similar regulatory circuits could be a common feature of other systems of cellular differentiation