Global, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019

Background The causes for immune-mediated inflammatory diseases (IMIDs) are diverse and the incidence trends of IMIDs from specific causes are rarely studied. The study aims to investigate the pattern and trend of IMIDs from 1990 to 2019. Methods We collected detailed information on six major causes of IMIDs, including asthma, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, psoriasis, and atopic dermatitis, between 1990 and 2019, derived from the Global Burden of Disease study in 2019. The average annual percent change (AAPC) in number of incidents and age standardized incidence rate (ASR) on IMIDs, by sex, age, region, and causes, were calculated to quantify the temporal trends. Findings In 2019, rheumatoid arthritis, atopic dermatitis, asthma, multiple sclerosis, psoriasis, inflammatory bowel disease accounted 1.59%, 36.17%, 54.71%, 0.09%, 6.84%, 0.60% of overall new IMIDs cases, respectively. The ASR of IMIDs showed substantial regional and global variation with the highest in High SDI region, High-income North America, and United States of America. Throughout human lifespan, the age distribution of incident cases from six IMIDs was quite different. Globally, incident cases of IMIDs increased with an AAPC of 0.68 and the ASR decreased with an AAPC of −0.34 from 1990 to 2019. The incident cases increased across six IMIDs, the ASR of rheumatoid arthritis increased (0.21, 95% CI 0.18, 0.25), while the ASR of asthma (AAPC = −0.41), inflammatory bowel disease (AAPC = −0.72), multiple sclerosis (AAPC = −0.26), psoriasis (AAPC = −0.77), and atopic dermatitis (AAPC = −0.15) decreased. The ASR of overall and six individual IMID increased with SDI at regional and global level. Countries with higher ASR in 1990 experienced a more rapid decrease in ASR. Interpretation The incidence patterns of IMIDs varied considerably across the world. Innovative prevention and integrative management strategy are urgently needed to mitigate the increasing ASR of rheumatoid arthritis and upsurging new cases of other five IMIDs, respectively. Funding The Global Burden of Disease Study is funded by the Bill and Melinda Gates Foundation. The project funded by Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38)

Assessment of soil quality indices in agricultural lands of Qazvin Province, Iran

Soil quality evaluation is a tool to improve soil management and land use system. A large number of different physical, chemical and biological properties of soil, known as soil quality indicators, are used to soil quality assessment. These properties, that are sensitive to stress or disturbance, are synthesized using numerical quality indices obtained by several different types of methods. The aim of this study was to compare two different methods for soil quality index calculation in agricultural lands of Qazvin Province, Iran. In particular, the Integrated Quality Index (IQI) and Nemoro Quality Index (NQI) models were applied using the indicator selection methods: Total Data Set (TDS) and Minimum Data Set (MDS). Ten soil quality indicators were included in TDS: pH, Electrical Conductivity (EC), Organic Matter (OM), Cation Exchange Capacity (CEC), percentage of equivalent CaCO3 (TNV), heavy metal content of cadmium (Cd), cobalt (Co), lead (Pb), chromium (Cr) and soil erodibility factor (K), while Principal Components Analysis (PCA) was used to select the indicators to include in MDS. The tested soil quality indices were appropriate to evaluate the effects of land management practices on soil quality. The results of the linear relationship as well as of the match analysis, among the approaches studied, identified better estimation of soil quality applying IQI index when compared to NQI index and higher values of agreement of TSD than MSD. However, also IQIMSD approach resulted in suitable evaluation of the effects of land management practices on soil quality. This latter result was particularly relevant in the area studied because the use of a limited number of indicators could allow to reduce the cost of the analysis and to increase the sampling density in order to obtain a more detailed evaluation of soil quality through a geostatistical approach. © 2013 Elsevier Ltd. All rights reserved

What is it like to be the wife of an addicted man in Iran? A qualitative study

Drug misuse is increasing and diversifying in Iran. This study is the first to explore in detail the impact on, and ways of coping used by, spouses of addicted men in Iran. Semi-structured interviews were conducted with 24 spouses. Four main themes were identified in the data: heart-breaking news of the husband's addiction; coping alone; progressive deterioration and suffering; and disruption of family relationships and finances. Reactions upon learning of the husband's addiction involved shock and collapse, and/or fear, disbelief and confusion. Spouses tried to hide the problem and to solve the problem alone, feeling for a long time as if they were "walking in the dark" without any social support and exposed to stigma. As time had gone on they had experienced distress and turmoil, and mixed feelings towards, and loss of trust and confidence in, their husbands, whose behaviour was increasingly unreliable. This had led to impairment in the relationship, and financial stress, and a general degradation and disruption of normal family life, leading to strain for spouses, akin to a state of burnout. Present findings confirm the conclusions of similar research conducted in other countries, that substance misuse in the family can have devastating effects for spouses, on children and all aspects of family life. The situation for Iranian wives may be compounded by the relatively closed nature of family life, and the existence of culturally based attitudes, including shame, towards "family defects" such as addiction. More information and support is needed for Iranian families of addicted individuals. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted

Dynamic relationship between house prices in Malaysia's major economic regions and Singapore house prices

Dynamic relationship between house prices in Malaysia’s major economic regions and Singapore house prices, Regional Studies. The purpose of this study is to examine house price diffusion among Malaysia’s major economic regions (Kuala Lumpur, Selangor, Pulau Pinang and Johor) and between each of these regions and neighbouring Singapore by using the quarterly data from 2000:Q1 to 2011:Q1. By applying multivariate co-integration approach, the results show the existence of ripple effects among Malaysia’s major economic regions. Moreover, it is found that house price diffusion observed within a country can be extended across the border. Implications are offered along with the findings of this research