21 research outputs found
Applicability and precautions of use of liver injury biomarker FibroTest. A reappraisal at 7 years of age
Get PDF<p>Abstract</p> <p>Background</p> <p>FibroTest (FT) is a validated biomarker of fibrosis. To assess the applicability rate and to reduce the risk of false positives/negatives (RFPN), security algorithms were developed. The aims were to estimate the prevalence of RFPN and of proven failures, and to identify factors associated with their occurrences.</p> <p>Methods</p> <p>Four populations were studied: 954 blood donors (P1), 7,494 healthy volunteers (P2), 345,695 consecutive worldwide sera (P3), including 24,872 sera analyzed in a tertiary care centre (GHPS) (P4). Analytical procedures of laboratories with RFPN > 5% and charts of P4 patients in with RFPN were reviewed.</p> <p>Results</p> <p>The prevalence of RFPN was 0.52% (5/954; 95%CI 0.17-1.22) in P1, 0.51% (38/7494; 0.36-0.70) in P2, and 0.97% (3349/345695; 0.94-1.00) in P3. Three a priori high-risk populations were confirmed: 1.97% in P4, 1.77% in HIV centre and 2.61% in Sub-Saharan origin subjects. RFPN was mostly associated with low haptoglobin (0.46%), and high apolipoproteinA1 (0.21%). A traceability study of a P3 laboratory with RFPFN > 5% permitted to correct analytical procedures.</p> <p>Conclusion</p> <p>The mean applicability rate of Fibrotest was 99.03%. Independent factors associated with the high risk of false positives/negatives were HIV center, subSaharan origin, and a tertiary care reference centre, although the applicability rate remained above 97%.</p
The relationship between surface tension and release of rat jejunal brush border membrane hydrolases induced by sodium deoxycholate
No full textInternational audienc
Influence of human haptoglobin polymorphism on oxidative stress induced by free hemoglobin on red blood cells.
No full textVariations of plasma enzyme activities and inflammation markers in severe head injury: a multivariate approach for patient monitoring and outcome prediction.
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Intermethod calibration of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) results: application to Fibrotest and Actitest scores.
No full textComparaison des tests microtox et daphnie pour l'evaluation de la toxicité aigue d'effluents industriels
No full textIFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C. Part 8. Reference procedure for the measurement of catalytic concentration of alpha-amylase [alpha-Amylase: 1,4-alpha-D-glucan 4-glucanohydrolase (AMY), EC 3.2.1.1].
No full textCatalytic Concentration of Alanine Aminotransferase (ALAT) Determined by IFCC Method at 37°C IRMM/IFCC-454.
No full textAbstract not availableJRC.D-Institute for Reference Materials and Measurements (Geel
