937 research outputs found

    Mapping ISO 27002 into security ontology

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    In recent years, due to the increasingly interconnected environment, information is exposed to a growing number of threats and vulnerabilities. Therefore, it is especially important for an organization to have an efficient information security management system. Recently, it has been observed that organisations are looking for standards of best practice for guidance on how to manage their information security infrastructures. In this way, they can demonstrate that their information is adequately secured, and show to their customers and business partners that they can be trusted with protection of the important information. This document presents a methodology of mapping the ISO 27002 standard knowledge to the security ontology and it is intended for organisations that aim to maintain compliance with it

    XY Spin Fluid in an External Magnetic Field

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    A method of integral equations is developed to study inhomogeneous fluids with planar spins in an external field. As a result, the calculations for these systems appear to be no more difficult than those for ordinary homogeneous liquids. The approach proposed is applied to the ferromagnetic XY spin fluid in a magnetic field using a soft mean spherical closure and the Born-Green-Yvon equation. This provides an accurate reproduction of the complicated phase diagram behavior obtained by cumbersome Gibbs ensemble simulation and multiple histogram reweighting techniques.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let

    Facilitating trypanosome imaging.

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    Research on trypanosomes as a model organism has provided a substantial contribution to a detailed understanding of basic cellular processes within the last few years. At the same time, major advances in super-resolution microscopy have been achieved, facilitating the resolution of biological structures in living cells at a scale of a few nm. However, the motility of trypanosomes has prevented access to high resolution microscopy of live cells. Here, we present a hydrogel based on poly(ethylene glycol) functionalized with either norbornene or thiol moieties for UV induced thiol-ene crosslinking for the embedding and imaging of live trypanosomes. The resulting gel exhibits low autofluorescence properties, immobilizes the cells efficiently on the nanometer scale and is compatible with cell viability for up to one hour at 24 °C. We applied super-resolution imaging to the inner plasma membrane leaflet using lipid-anchored eYFP as a probe. We find specific domains within the membrane where the fluorescence either accumulates or appears diluted rather than being homogenously distributed. Based on a Ripley's analysis, the size of the domains was determined to be raccumulated=170±5 nm and rdilute>115±15 nm. We hypothesize that this structuring of the membrane is associated with the underlying cytoskeleton.ME is supported by DFG grants EN305 and SPP1726. ME is a member of the Wilhelm Conrad Röntgen Center for Complex Material Systems (RCCM). Work in MC's lab was funded by the a Wellcome Trust award (093008/Z10/Z)

    Concentration and mass dependence of transport coefficients and correlation functions in binary mixtures with high mass-asymmetry

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    Correlation functions and transport coefficients of self-diffusion and shear viscosity of a binary Lennard-Jones mixture with components differing only in their particle mass are studied up to high values of the mass ratio μ\mu, including the limiting case μ=\mu=\infty, for different mole fractions xx. Within a large range of xx and μ\mu the product of the diffusion coefficient of the heavy species D2D_{2} and the total shear viscosity of the mixture ηm\eta_{m} is found to remain constant, obeying a generalized Stokes-Einstein relation. At high liquid density, large mass ratios lead to a pronounced cage effect that is observable in the mean square displacement, the velocity autocorrelation function and the van Hove correlation function

    Equity research report asml holding nv - shaping everyone-s digital future

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    ASML is the world's leading provider of lithography systems for the semiconductor industry, manufacturing complex machines that are critical to the production of integrated circuits or chips. The key objective is to analyse the complex nature of the business of ASML NV and evaluate a share price goal for FY2023. To examine the company, annual statements from 2018 to 2021 are exploited. We provide an overview of ASML’s landscape and insights into the financial statements. The report includes a discussion of ASML's business model, product portfolio, and competitive advantage. The program used to analyse the data is Excel. Moreover, the semiconductor, as well as the lithograph industry, and a possible impact of macroeconomic factors regarding the valuation, market trends and dynamics, are discussed. Semiconductors are becoming an increasingly essential factor in the world’s economy, especially to justify and explain the digital transformation and the overall development of countries and its population. Overall, ASML is well positioned to continue its strong performance, while stressing the importance and implication of such market power regarding lithography

    Phase diagrams of classical spin fluids: the influence of an external magnetic field on the liquid-gas transition

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    The influence of an external magnetic field on the liquid-gas phase transition in Ising, XY, and Heisenberg spin fluid models is studied using a modified mean field theory and Gibbs ensemble Monte Carlo simulations. It is demonstrated that the theory is able to reproduce quantitatively all characteristic features of the field dependence of the critical temperature T_c(H) for all the three models. These features include a monotonic decrease of T_c with rising H in the case of the Ising fluid as well as a more complicated nonmonotonic behavior for the XY and Heisenberg models. The nonmonotonicity consists in a decrease of T_c with increasing H at weak external fields, an increase of T_c with rising H in the strong field regime, and the existence of a minimum in T_c(H) at intermediate values of H. Analytical expressions for T_c(H) in the large field limit are presented as well. The magnetic para-ferro phase transition is also considered in simulations and described within the mean field theory.Comment: 14 pages, 12 figures (to be submitted to Phys. Rev. E

    Arrangement of Annexin A2 tetramer and its impact on the structure and diffusivity of supported lipid bilayers

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    Annexins are a family of proteins that bind to anionic phospholipid membranes in a Ca2+-dependent manner. Annexin A2 forms heterotetramers (Anx A2t) with the S100A10 (p11) protein dimer. The tetramer is capable of bridging phospholipid membranes and it has been suggested to play a role in Ca2+-dependent exocytosis and cell-cell adhesion of metastatic cells. Here, we employ x-ray reflectivity measurements to resolve the conformation of Anx A2t upon Ca2+-dependent binding to single supported lipid bilayers (SLBs) composed of different mixtures of anionic (POPS) and neutral (POPC) phospholipids. Based on our results we propose that Anx A2t binds in a side-by-side configuration, i.e., both Anx A2 monomers bind to the bilayer with the p11 dimer positioned on top. Furthermore, we observe a strong decrease of lipid mobility upon binding of Anx A2t to SLBs with varying POPS content. X-ray reflectivity measurements indicate that binding of Anx A2t also increases the density of the SLB. Interestingly, in the protein-facing leaflet of the SLB the lipid density is higher than in the substrate-facing leaflet. This asymmetric densification of the lipid bilayer by Anx A2t and Ca2+ might have important implications for the biochemical mechanism of Anx A2t-induced endo- and exocytosis.Comment: 27 pages, 7 figures; supplementary material available upon request from the author

    Information Security Risk Management: In Which Security Solutions Is It Worth Investing?

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    As companies are increasingly exposed to information security threats, decision makers are permanently forced to pay attention to security issues. Information security risk management provides an approach for measuring the security through risk assessment, risk mitigation, and risk evaluation. Although a variety of approaches have been proposed, decision makers lack well-founded techniques that (1) show them what they are getting for their investment, (2) show them if their investment is efficient, and (3) do not demand in-depth knowledge of the IT security domain. This article defines a methodology for management decision makers that effectively addresses these problems. This work involves the conception, design, and implementation of the methodology into a software solution. The results from two qualitative case studies show the advantages of this methodology in comparison to established methodologies

    Automated Transformation of Semi-Structured Text Elements

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    Interconnected systems, such as electronic health records (EHR), considerably improved the handling and processing of health information while keeping the costs at a controlled level. Since the EHR virtually stores all data in digitized form, personal medical documents are easily and swiftly available when needed. However, multiple formats and differences in the health documents managed by various health care providers severely reduce the efficiency of the data sharing process. This paper presents a rule-based transformation system that converts semi-structured (annotated) text into standardized formats, such as HL7 CDA. It identifies relevant information in the input document by analyzing its structure as well as its content and inserts the required elements into corresponding reusable CDA templates, where the templates are selected according to the CDA document type-specific requirements
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