Serum IL-17 after one course of sublingual immunotherapy in allergic rhinitis to birch

Recently, it has been reported that IL-17 may be involved in allergic reaction. Sublingual immunotherapy (SLIT) is the unique curative treatment for allergic rhinitis. This study aims at investigating whether one course of birch SLIT could affect serum IL-17 levels. The findings provided show that some IL-17 producer patients had a reduction of serum IL-17 levels after one SLIT course. Therefore, this preliminary study shows that a single pre-seasonal SLIT course may induce a significant decreasing trend in serum IL-17 levels; further study should be carried out to define the role exerted by IL-17 in allergic rhinitis

Habitat Preferences of Italian Freshwater Fish: A Systematic Review of Data Availability for Applications of the MesoHABSIM Model

The MesoHABitat SImulation Model (MesoHABSIM) is the preferred method to calculate spatio-temporal variation in the fish habitat availability in Italian rivers. With the aim of improving the applicability of the MesoHABSIM approach in the Italian territory, we carried out a systematic review of physical habitat preferences for 31 freshwater fish species and three freshwater lampreys, representing 75% of the total indigenous freshwater fish community of Italy. Information related to suitable ranges of depth, flow velocity, biotic/abiotic substrates, covers/shelters was collected and summarized for two critical life stages (adult and juvenile) and two bioperiods (rearing/growth and spawning). Overall, 250 publications were reviewed, classified as 206 peer-reviewed papers, 20 books, 7 PhD thesis, and 17 grey literature sources. Our analysis revealed substantial deficits of information about habitat requirements for more than 30% of Italian freshwater fish species. This information is particularly scarce for the most threatened endemic species, especially for their most critical bioperiod (i.e., spawning). With the aim of preserving freshwater fish biodiversity as required in the EU Biodiversity Strategy for 2030 (European Commission, 2020), accurate information on physical habitat requirements for spawning is crucial. As an example application of MesoHABSIM, the collected habitat preference information was used to define and apply mesohabitat suitability criteria for one fish species (Telestes muticellus) in a regulated river reach of Argentina Creek (Province of Imperia, Italy). This analysis demonstrates the potential for applying information from the current review to other fish species

Dual Effect of Methylprednsolone Pulses on Apoptosis of Peripheral Leukocytes in Patients with Renal Diseases

It is well known that change in apoptosis may modulate the natural story of illness, and that many drugs may act through modulation of apoptosis, but the role of steroids in acting through apoptosis in different settings, including renal diseases, has still to be elucidated. We studied the in vivo effects of steroids by oral assumption (10 to 25 mg/deltacortene) or by intravenous pulses (300 to 1000 mg/dose) on apoptosis and cellular subsets of peripheral lymphocytes, by evaluating DNA-fragmentation and lymphocyte subsets in 79 subjects: 22 controls and 57 patients with various renal diseases (25 Lupus-GN, 19 membranous-GN (MGN), 6 rapidly progressive-GN (RPGN), 2 acute interstitial nephritis (AIN), 5 on chronic dialysis. Baseline apoptosis was present in 1/22 (4.5%) of controls, 3/25 (12%) SLE, 2/6 (33.3%) RPGN and 10/19 (52.6%) MGN. A significant decrease in CD3+CD8+ cell count and a significant increase of the CD3+CD4/CD3+CD8+ ratio were found in apoptosis-positive subjects. DNA fragmentation did not change after oral steroids, paralleling a 22 to 32% decrease in total lymphocytes. Following intravenous methylprednisolone pulses, a deeper drop of all lymphocyte subsets was observed, while DNA fragmentation turned from present to absent in 2 MGN, but not in 2 RPGN, and from absent to present in 1 ARF and 1 SLE, independently of the dosage. We demonstrated that the presence of apoptosis in renal diseases is associated with decreased CD3+CD8+ cell count. Furthermore, steroid intravenous pulses, besides inducing a profound decrease in lymphocyte subsets, do exert a dual effect on baseline leukocyte apoptosis, eventually leading to a reversal of baseline patterns, either turning from negative to positive or from positive to negative. Oral steroid therapy did not influence baseline apoptosis

The geometrical nature of optical resonances : from a sphere to fused dimer nanoparticles

We study the electromagnetic response of smooth gold nanoparticles with shapes varying from a single sphere to two ellipsoids joined smoothly at their vertices. We show that the plasmonic resonance visible in the extinction and absorption cross sections shifts to longer wavelengths and eventually disappears as the mid-plane waist of the composite particle becomes narrower. This process corresponds to an increase of the numbers of internal and scattering modes that are mainly confined to the surface and coupled to the incident field. These modes strongly affect the near field, and therefore are of great importance in surface spectroscopy, but are almost undetectable in the far field