Fear and Greed in Tax Policy: A Qualitative Research Agenda

While there is a general consensus that most people dislike paying taxes, more empirical data is needed to determine how, and to what extent, tax aversion plays a role in taxpayer behavior. If tax aversion occurs at significant levels, it becomes important to isolate and explore the constitutive elements of that aversion. A better understanding of the causes and components of tax aversion could spur useful innovation in tax design. In this Essay, we survey and mine existing bodies of empirical work for the insights they might bring to bear on these questions, while constructing a qualitative research agenda that begins to fill the remaining gaps. To focus our inquiry, we concentrate primarily on the federal income tax

Fear and Greed in Tax Policy: A Qualitative Research Agenda

While there is a general consensus that most people dislike paying taxes, more empirical data is needed to determine how, and to what extent, tax aversion plays a role in taxpayer behavior. If tax aversion occurs at significant levels, it becomes important to isolate and explore the constitutive elements of that aversion. A better understanding of the causes and components of tax aversion could spur useful innovation in tax design. In this Essay, we survey and mine existing bodies of empirical work for the insights they might bring to bear on these questions, while constructing a qualitative research agenda that begins to fill the remaining gaps. To focus our inquiry, we concentrate primarily on the federal income tax

Group Identity, Individual Creativity, and Symbolic Generation in a BaKongo Diaspora.”

1 This article applies theories of group dynamics and individual agency to past material expressions of core symbols within particular African American religious beliefs. The past creation and use of such artifacts is analyzed using theories concerning modes of symbolic expression, the interplay of dominant and nondominant religions, formation and maintenance of social group identities, and the role of individual creativity and innovation within those processes. This analysis demonstrates the ways in which facets of the core symbolic expressions of the BaKongo people of West Central Africa evolved over time and across the trans-Atlantic region

Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia.

Non-genetic drug resistance is increasingly recognised in various cancers. Molecular insights into this process are lacking and it is unknown whether stable non-genetic resistance can be overcome. Using single cell RNA-sequencing of paired drug naïve and resistant AML patient samples and cellular barcoding in a unique mouse model of non-genetic resistance, here we demonstrate that transcriptional plasticity drives stable epigenetic resistance. With a CRISPR-Cas9 screen we identify regulators of enhancer function as important modulators of the resistant cell state. We show that inhibition of Lsd1 (Kdm1a) is able to overcome stable epigenetic resistance by facilitating the binding of the pioneer factor, Pu.1 and cofactor, Irf8, to nucleate new enhancers that regulate the expression of key survival genes. This enhancer switching results in the re-distribution of transcriptional co-activators, including Brd4, and provides the opportunity to disable their activity and overcome epigenetic resistance. Together these findings highlight key principles to help counteract non-genetic drug resistance