1,837 research outputs found

    PDH22: MODELLING THE BENEFITS OF VERTEPORFIN THERAPY IN MACULAR DEGENERATION

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    Homology of Distributive Lattices

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    We outline the theory of sets with distributive operations: multishelves and multispindles, with examples provided by semi-lattices, lattices and skew lattices. For every such a structure we define multi-term distributive homology and show some of its properties. The main result is a complete formula for the homology of a finite distributive lattice. We also indicate the answer for unital spindles and conjecture the general formula for semi-lattices and some skew lattices. Then we propose a generalization of a lattice as a set with a number of idempotent operations satisfying the absorption law.Comment: 30 pages, 3 tables, 3 figure

    A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68)

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    <i>Aims/hypothesis</i> The aim of this study was to develop a simulation model for Type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health economic outcomes such as quality-adjusted life expectancy. <i>Methods</i> Equations for forecasting the occurrence of seven diabetes-related complications and death were estimated using data on 3642 patients from the United Kingdom Prospective Diabetes Study (UKPDS). After examining the internal validity, the UKPDS Outcomes Model was used to simulate the mean difference in expected quality-adjusted life years between the UKPDS regimens of intensive and conventional blood glucose control. <i>Results</i> The models forecasts fell within the 95% confidence interval for the occurrence of observed events during the UKPDS follow-up period. When the model was used to simulate event history over patients lifetimes, those treated with a regimen of conventional glucose control could expect 16.35 undiscounted quality-adjusted life years, and those receiving treatment with intensive glucose control could expect 16.62 quality-adjusted life years, a difference of 0.27 (95% CI: –0.48 to 1.03). <i>Conclusions/interpretations</i> The UKPDS Outcomes Model is able to simulate event histories that closely match observed outcomes in the UKPDS and that can be extrapolated over patients lifetimes. Its validity in estimating outcomes in other groups of patients, however, remains to be evaluated. The model allows simulation of a range of long-term outcomes, which should assist in informing future economic evaluations of interventions in Type 2 diabetes

    Economical adjunction of square roots to groups

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    How large must an overgroup of a given group be in order to contain a square root of any element of the initial group? We give an almost exact answer to this question (the obtained estimate is at most twice worse than the best possible) and state several related open questions.Comment: 5 pages. A Russian version of this paper is at http://mech.math.msu.su/department/algebra/staff/klyachko/papers.htm V2: minor correction

    Taxonomies of networks from community structure

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    The study of networks has become a substantial interdisciplinary endeavor that encompasses myriad disciplines in the natural, social, and information sciences. Here we introduce a framework for constructing taxonomies of networks based on their structural similarities. These networks can arise from any of numerous sources: They can be empirical or synthetic, they can arise from multiple realizations of a single process (either empirical or synthetic), they can represent entirely different systems in different disciplines, etc. Because mesoscopic properties of networks are hypothesized to be important for network function, we base our comparisons on summaries of network community structures. Although we use a specific method for uncovering network communities, much of the introduced framework is independent of that choice. After introducing the framework, we apply it to construct a taxonomy for 746 networks and demonstrate that our approach usefully identifies similar networks. We also construct taxonomies within individual categories of networks, and we thereby expose nontrivial structure. For example, we create taxonomies for similarity networks constructed from both political voting data and financial data. We also construct network taxonomies to compare the social structures of 100 Facebook networks and the growth structures produced by different types of fungi

    Quasi-Quantum Groups, Knots, Three-Manifolds, and Topological Field Theory

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    We show how to construct, starting from a quasi-Hopf algebra, or quasi-quantum group, invariants of knots and links. In some cases, these invariants give rise to invariants of the three-manifolds obtained by surgery along these links. This happens for a finite-dimensional quasi-quantum group, whose definition involves a finite group GG, and a 3-cocycle \om, which was first studied by Dijkgraaf, Pasquier and Roche. We treat this example in more detail, and argue that in this case the invariants agree with the partition function of the topological field theory of Dijkgraaf and Witten depending on the same data G, \,\om.Comment: 30 page
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