A Multilingual Benchmark to Capture Olfactory Situations over Time

We present a benchmark in six European languages containing manually annotated information about olfactory situations and events following a FrameNet-like approach. The documents selection covers ten domains of interest to cultural historians in the olfactory domain and includes texts published between 1620 to 1920, allowing a diachronic analysis of smell descriptions. With this work, we aim to foster the development of olfactory information extraction approaches as well as the analysis of changes in smell descriptions over time

GBA variants in REM sleep behavior disorder: a multicenter study

To study the role of GBA variants in the risk for isolated rapid-eye-movement (REM)-sleep behavior disorder (iRBD) and conversion to overt neurodegeneration

Genome-wide association study of REM sleep behavior disorder identifies polygenic risk and brain expression effects

Rapid-eye movement (REM) sleep behavior disorder (RBD), enactment of dreams during REM sleep, is an early clinical symptom of alpha-synucleinopathies and defines a more severe subtype. The genetic background of RBD and its underlying mechanisms are not well understood. Here, we perform a genome-wide association study of RBD, identifying five RBD risk loci near SNCA, GBA, TMEM175, INPP5F, and SCARB2. Expression analyses highlight SNCA-AS1 and potentially SCARB2 differential expression in different brain regions in RBD, with SNCA-AS1 further supported by colocalization analyses. Polygenic risk score, pathway analysis, and genetic correlations provide further insights into RBD genetics, highlighting RBD as a unique alpha-synucleinopathy subpopulation that will allow future early intervention

HLA in isolated REM sleep behavior disorder and Lewy body dementia

peer reviewedSynucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95 CI = 1.27–1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95\%CI = 1.12–1.41, p = 8.76e-05), 70Q (OR = 0.81, 95\%CI = 0.72–0.91, p = 3.65e-04) and 71R (OR = 1.21, 95\%CI = 1.08–1.35, p = 1.35e-03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies

A mathematical approach to understanding emergent constraints

One of the approaches to constrain uncertainty in climate models is the identification of emergent constraints. These are physically explainable empirical relationships between a particular simulated characteristic of the current climate and future climate change from an ensemble of climate models, which can be exploited using current observations. In this paper, we develop a theory to understand the appearance of such emergent constraints. Based on this theory, we also propose a classification for emergent constraints, and applications are shown for several idealized climate models.

Fear of blushing: Relations with personality among children and adults

Despite the common nature of blushing and the feelings of discomfort that often accompany it, to date. no studies have yet examined the relationship between personality characteristics and the fear of blushing. The present study fills this gap in the literature, by examining, in a sample of adults and a sample of children (9-16 years), the relationship between personality and fear of blushing. For this purpose questionnaires were administered to representative community samples of adults (n = 157) and children (n = 150). Results showed that, among adults, fear of blushing was best predicted by Structure, whereas, among children, fear of blushing was best predicted by Neuroticism. When comparing the two samples, children reported more fear of blushing than adults, whereas, across samples, females reported more fear of blushing than males. Conclusions are discussed as well as future directions for research. (C) 2014 Elsevier Ltd. All rights reserved