Combating CVD in Kazakhstan through workplace interventions

The project designs and tests a multifaceted worksite intervention protocol that includes smoking cessation, dietary instruction, and exercise regimens to lower the prevalence of CVD morbidity and mortality in Kazakhstan. Kazakhstan has among the highest CVD morbidity and mortality rates in the world. Development of an effective worksite intervention model that targets and improves the health behaviors and health status of high-risk middle age working males can be extended to the Republic's crucial and expanding workplace environment

Combating CVD in Kazakhstan through workplace interventions

The project designs and tests a multifaceted worksite intervention protocol that includes smoking cessation, dietary instruction, and exercise regimens to lower the prevalence of CVD morbidity and mortality in Kazakhstan. Kazakhstan has among the highest CVD morbidity and mortality rates in the world. Development of an effective worksite intervention model that targets and improves the health behaviors and health status of high-risk middle age working males can be extended to the Republic's crucial and expanding workplace environment

Toward a Scholarship of Teaching and Learning in Educational Development

Educational development traditionally has been a practice-based field. We propose that as a profession we adopt the methods of the scholarship of teaching and learning (SoTL), so often shared with our clients, in order to look through a scholarly lens at the outcomes of our own practice. Using SoTL approaches in our work would deepen the research literature in our field and improve the effectiveness of decisions we make about where to spend limited time and resources. In this chapter, we explore what it might mean for individual developers, and for our professional community, to apply SoTL methods to our practice

Blazar synchrotron emission of instantaneously power-law injected electrons under linear synchrotron, non-linear SSC, and combined synchrotron-SSC cooling

The broadband SEDs of blazars show two distinct components which in leptonic models are associated with synchrotron and SSC emission of highly relativistic electrons. In some sources the SSC component dominates the synchrotron peak by one or more orders of magnitude implying that the electrons mainly cool by inverse Compton collisions with their self-made synchrotron photons. Therefore, the linear synchrotron loss of electrons, which is normally invoked in emission models, has to be replaced by a nonlinear loss rate depending on an energy integral of the electron distribution. This modified electron cooling changes significantly the emerging radiation spectra. It is the purpose of this work to apply this new cooling scenario to relativistic power-law distributed electrons, which are injected instantaneously into the jet. We will first solve the differential equation of the volume-averaged differential number density of the electrons, and then discuss their temporal evolution. Since any non-linear cooling will turn into linear cooling after some time, we also calculated the electron number density for a combined cooling scenario consisting of both the linear and non-linear cooling. For all cases, we will also calculate analytically the emerging optically thin synchrotron fluence spectrum which will be compared to a numerical solution. For small normalized frequencies f < 1 the fluence spectra show constant spectral indices. We find for linear cooling a_SYN = 1/2, and for non-linear cooling a_SSC = 3/2. In the combined cooling scenario we obtain for the small injection parameter b_1 = 1/2, and for the large injection parameter b_2 = 3/2, which becomes b_1 = 1/2 for very small frequencies, again. This is the same behaviour as for monoenergetically injected electrons.Comment: 24 pages, 25 figures, submitted to A&

CHANDRA Observations of X-ray Jet Structure on kpc to Mpc Scales

With its exquisite spatial resolution of better than 0.5 arcsecond, the Chandra observatory is uniquely capable of resolving and studying the spatial structure of extragalactic X-ray jets on scales of a few to a few hundred kilo-parsec. Our analyses of four recent Chandra images of quasar jets interpret the X-ray emission as inverse Compton scattering of high energy electrons on the cosmic microwave background. We infer that these jets are in bulk relativistic motion, carrying kinetic powers upwards of 10^46 ergs/s to distances of hundreds of kpc, with very high efficiency.Comment: 4 pages, 3 figures, to be published in the proceedings of the Bologna jet workshop, "The Physics of Relativistic Jets in the CHANDRA and XMM Era.

POS0758 DOES EXPERIENCE IN SYSTEMIC LUPUS ERYTHEMATOSUS INFLUENCE THE PHYSICIAN GLOBAL ASSESSMENT SCORING? A CROSS-SECTIONAL STUDY ON TWO EUROPEAN COHORTS

Background:The Physician Global Assessment (PGA) is an outcome instrument based on physician judgement of disease activity in patients with Systemic Lupus Erythematosus (SLE). Due to the subjectivity of the score and lack of standardization, the PGA could represent a source of heterogeneity, because the same manifestations could be rated differently by physicians with different backgrounds (1).Objectives:The purpose of this study was to evaluate the inter-rater reliability of PGA between a rheumatology trainee and rheumatologists expert in SLE from 2 european countries.Methods:SLE patients classified according to SLICC 2012 criteria were enrolled between May 2019 and December 2019 during a SLEuro traineeship program. Demographic, clinical (SLEDAI-2k, PGA), serological and ongoing medication data were collected. PGA was evaluated before (pre-lab) and after (post-lab) knowledge of laboratory exams, using a Visual Analogue Scale (VAS) ranging from 0 to 3, anchored at point 1 (mild), 2 (moderate) and 3 (severe activity). A trainee in Rheumatology (EC) and three rheumatologists experts in SLE (LA, MP, FS) independently scored the PGA for each patient.The trainee preliminarily received a standardization training with her tutor (MP), consisting of a shared discussion about 10 consecutive SLE outpatients to increase reliability in PGA scoring.Inter-rater reliability was analysed using the intraclass correlation coefficient (ICC) with a two-way single-rating model (2,1); 95% confidence interval (CI) was calculated.Results:Fifty-seven patients (86% female) affected from SLE (29 belonging to a French cohort and 28 to an Italian cohort) with a mean (SD) age 43.2 (15.9) years and a median [IQR] disease duration 6.4 [2.0-15.4] years were enrolled. Clinical features are presented in table 1. Pre-lab PGA scores were obtained from all patients and ranged from 0 to 2.3; post-lab PGA scores were obtained from 51 patients and ranged from 0 to 2.9. Inter-rater reliability of the PGA among the trainee was good to excellent for each lupus expert comparison: a) pre-lab PGA ICC 0.94, 95% CI 0.87-0.97; post-lab PGA ICC 0.94, 95% CI 0.87-0.97 (MP); b) pre-lab PGA ICC 0.84, 95% CI 0.63-0.93; post-lab PGA ICC 0.96 CI 0.88-0.99 (LA); c) pre-lab PGA ICC 0.91, 95% CI 0.65-0.98; post-lab PGA ICC 0.91, 95% CI 0.65-0.98 (FS).Conclusion:After an adequate standardization, PGA scoring reaches good to excellent reliability between trainee and experts.References:[1]Chessa E, Piga M, Floris A, Devilliers H, Cauli A, Arnaud L. Use of Physician Global Assessment in systemic lupus erythematosus: a systematic review of its psychometric properties. Rheumatology (Oxford). 2020 Dec 1;59(12):3622-3632.Clinical DataCaucasian44 (77.2%)anti-dsDNA titre (median,IQR)14 (0-75)Hypocomplementemia (n,%)30 (54%)SLEDAI≥6 (n,%)18 (31.6%)SLEDAI (median,IQR)4 (2-6)Flares (n,%)18 (31.6%)Ongoing prednisone treatment (n,%)41 (71.9%)Prednisone dose mg (mean±sd)5 (0 - 8.9)Hydroxychloroquine (n,%)44 (77.2%)Immunosuppressant (n,%)35 (61.4%)Acknowledgements:Elisabetta Chessa gratefully acknowledges the SLEuro European Lupus Society for its financial support in her traineeship in Strasbourg.Disclosure of Interests:None declare

The Seyfert Population in the Local Universe

The magnitude-limited catalog of the Southern Sky Redshift Survey (SSRS2), is used to characterize the properties of galaxies hosting Active Galactic Nuclei. Using emission-line ratios, we identify a total of 162 (3%) Seyfert galaxies out of the parent sample with 5399 galaxies. The sample contains 121 Seyfert 2 galaxies and 41 Seyfert 1. The SSRS2 Seyfert galaxies are predominantly in spirals of types Sb and earlier, or in galaxies with perturbed appearance as the result of strong interactions or mergers. Seyfert galaxies in this sample are twice as common in barred hosts than the non-Seyferts. By assigning galaxies to groups using a percolation algorithm we find that the Seyfert galaxies in the SSRS2 are more likely to be found in binary systems, when compared to galaxies in the SSRS2 parent sample. However, there is no statistically significant difference between the Seyfert and SSRS2 parent sample when systems with more than 2 galaxies are considered. The analysis of the present sample suggests that there is a stronger correlation between the presence of the AGN phenomenon with internal properties of galaxies (morphology, presence of bar, luminosity) than with environmental effects (local galaxy density, group velocity dispersion, nearest neighbor distance).Comment: 35 pages, 13 figures, Accepted to be publised in Astronomical Journa

Solution of the Two-Channel Anderson Impurity Model - Implications for the Heavy Fermion UBe13_{13} -

We solve the two-channel Anderson impurity model using the Bethe-Ansatz. We determine the ground state and derive the thermodynamics, obtaining the impurity entropy and specific heat over the full range of temperature. We show that the low temperature physics is given by a line of fixed points decribing a two-channel non Fermi liquid behavior in the integral valence regime associated with moment formation as well as in the mixed valence regime where no moment forms. We discuss relevance for the theory of UBe$_{13}$.Comment: 4 pages, 2 figures, (to be published in PRL

Novel Microdialysis Technique Reveals a Dramatic Shift in Metabolite Secretion during the Early Stages of the Interaction between the Ectomycorrhizal Fungus Pisolithus microcarpus and Its Host Eucalyptus grandis

The colonisation of tree roots by ectomycorrhizal (ECM) fungi is the result of numerous signalling exchanges between organisms, many of which occur before physical contact. However, information is lacking about these exchanges and the compounds that are secreted by each organism before contact. This is in part due to a lack of low disturbance sampling methods with sufficient temporal and spatial resolution to capture these exchanges. Using a novel in situ microdialysis approach, we sampled metabolites released from Eucalyptus grandis and Pisolithus microcarpus independently and during indirect contact over a 48-h time-course using UPLC-MS. A total of 560 and 1530 molecular features (MFs; ESI- and ESI+ respectively) were identified with significant differential abundance from control treatments. We observed that indirect contact between organisms altered the secretion of MFs to produce a distinct metabolomic profile compared to either organism independently. Many of these MFs were produced within the first hour of contact and included several phenylpropanoids, fatty acids and organic acids. These findings show that the secreted metabolome, particularly of the ECM fungus, can rapidly shift during the early stages of pre-symbiotic contact and highlight the importance of observing these early interactions in greater detail. We present microdialysis as a useful tool for examining plant-fungal signalling with high temporal resolution and with minimal experimental disturbance

Effect of four plant species on soil 15N-access and herbage yield in temporary agricultural grasslands

Positive plant diversity-productivity relationships have been reported for experimental semi-natural grasslands (Cardinale et al. 2006; Hector et al. 1999; Tilman et al. 1996) as well as temporary agricultural grasslands (Frankow-Lindberg et al. 2009; Kirwan et al. 2007; Nyfeler et al. 2009; Picasso et al. 2008). Generally, these relationships are explained, on the one hand, by niche differentiation and facilitation (Hector et al. 2002; Tilman et al. 2002) and, on the other hand, by greater probability of including a highly productive plant species in high diversity plots (Huston 1997). Both explanations accept that diversity is significant because species differ in characteristics, such as root architecture, nutrient acquisition and water use efficiency, to name a few, resulting in composition and diversity being important for improved productivity and resource use (Naeem et al. 1994; Tilman et al. 2002). Plant diversity is generally low in temporary agricultural grasslands grown for ruminant fodder production. Grass in pure stands is common, but requires high nitrogen (N) inputs. In terms of N input, two-species grass-legume mixtures are more sustainable than grass in pure stands and consequently dominate low N input grasslands (Crews and Peoples 2004; Nyfeler et al. 2009; Nyfeler et al. 2011). In temperate grasslands, N is often the limiting factor for productivity (Whitehead 1995). Plant available soil N is generally concentrated in the upper soil layers, but may leach to deeper layers, especially in grasslands that include legumes (Scherer-Lorenzen et al. 2003) and under conditions with surplus precipitation (Thorup-Kristensen 2006). To improve soil N use efficiency in temporary grasslands, we propose the addition of deep-rooting plant species to a mixture of perennial ryegrass and white clover, which are the most widespread forage plant species in temporary grasslands in a temperate climate (Moore 2003). Perennial ryegrass and white clover possess relatively shallow root systems (Kutschera and Lichtenegger 1982; Kutschera and Lichtenegger 1992) with effective rooting depths of <0.7 m on a silt loamy site (Pollock and Mead 2008). Grassland species, such as lucerne and chicory, grow their tap-roots into deep soil layers and exploit soil nutrients and water in soil layers that the commonly grown shallow-rooting grassland species cannot reach (Braun et al. 2010; Skinner 2008). Chicory grown as a catch crop after barley reduced the inorganic soil N down to 2.5 m depth during the growing season, while perennial ryegrass affected the inorganic soil N only down to 1 m depth (Thorup-Kristensen 2006). Further, on a Wakanui silt loam in New Zealand chicory extracted water down to 1.9 m and lucerne down to 2.3 m soil depth, which resulted in greater herbage yields compared with a perennial ryegrass-white clover mixture, especially for dryland plots (Brown et al. 2005). There is little information on both the ability of deep- and shallow-rooting grassland species to access soil N from different vertical soil layers and the relation of soil N-access and herbage yield in temporary agricultural grasslands. Therefore, the objective of the present work was to test the hypotheses 1) that a mixture comprising both shallow- and deep-rooting plant species has greater herbage yields than a shallow-rooting binary mixture and pure stands, 2) that deep-rooting plant species (chicory and lucerne) are superior in accessing soil N from 1.2 m soil depth compared with shallow-rooting plant species, 3) that shallow-rooting plant species (perennial ryegrass and white clover) are superior in accessing soil N from 0.4 m soil depth compared with deep-rooting plant species, 4) that a mixture of deep- and shallow-rooting plant species has greater access to soil N from three soil layers compared with a shallow-rooting two-species mixture and that 5) the leguminous grassland plants, lucerne and white clover, have a strong impact on grassland N acquisition, because of their ability to derive N from the soil and the atmosphere