CAD Model Details via Curved Knot Lines and Truncated Powers

This paper describes a method for adding surface details to existing CAD models. Our approach is based on truncated powers, which allows us to align the added details with curved knot lines on the surface. Additionally, (truncated) powers give us precise control over the continuity of the perturbed surface across the (curved) knot lines. Our representation is compatible with current CAD/CAM practise and standards, and we showcase it on several examples

Micro Methods for Megafauna: Novel Approaches to Late Quaternary Extinctions and Their Contributions to Faunal Conservation in the Anthropocene

Drivers of Late Quaternary megafaunal extinctions are relevant to modern conservation policy in a world of growing human population density, climate change, and faunal decline. Traditional debates tend toward global solutions, blaming either dramatic climate change or dispersals of Homo sapiens to new regions. Inherent limitations to archaeological and paleontological data sets often require reliance on scant, poorly resolved lines of evidence. However, recent developments in scientific technologies allow for more local, context-specific approaches. In the present article, we highlight how developments in five such methodologies (radiocarbon approaches, stable isotope analysis, ancient DNA, ancient proteomics, microscopy) have helped drive detailed analysis of specific megafaunal species, their particular ecological settings, and responses to new competitors or predators, climate change, and other external phenomena. The detailed case studies of faunal community composition, extinction chronologies, and demographic trends enabled by these methods examine megafaunal extinctions at scales appropriate for practical understanding of threats against particular species in their habitats today. </section

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment

Modeling the co-precipitation of silica and calcium oxalate in sugar solutions

Solution chemistry plays a significant role in the rate and type of foulant formed on heated industrial surfaces. This paper describes the effect of sucrose, silica (SiO2), Ca2+ and Mg2+ ions, and trans-aconitic acid on the kinetics and solubility of SiO2 and calcium oxalate monohydrate (COM) in mixed salt solutions containing sucrose and refines models previously proposed. The developed SiO2 models show that sucrose and SiO2 concentrations are the main parameters that determine apparent order (n) and apparent rate of reaction (k) and SiO2 solubility over a 24 h period. The calcium oxalate solubility model shows that while increasing [Mg2+] increases COM solubility, the reverse is so with increasing sucrose concentrations. The role of solution species on COM crystal habit is discussed and the appearance of the uncommon (001) face is explained

Polymer Education in Australia

The coverage of polymer science and engineering in Australian universities was surveyed by contacting respondents and accessing course and unit catalogues of Australian universities. It was found that the breadth and extent of undergraduate education in polymers was not strongly correlated with the profile of polymer-related research at an institution, and that few institutions appeared to have a systemic commitment to polymer science. Polymer education was stronger in engineering faculties than science faculties, with a majority of Australian undergraduate students studying polymers to a significant extent enrolled in BEng programs. Most responses were consistent with a decline in polymer education over the past few decades, with units of study no longer offered and the reduction of polymer content in the units that remained. It was estimated that approximately 700 students with significant exposure to polymers graduate from Australian BSc and BEng programs annually. Given the small extent of the Australian polymer industry and the large proportion of foreign-trained professionals in Australia, the extent of polymer education in Australia appears to be adequate for the needs of the country

Cargo-Cult Science and the Mimesis of Research Practice: Response to "Critical Discourse Analysis of Rhetoric Against Complementary Medicine"

Critical Discourse Analysis may be broadly understood as the analysis of linguistic structures to determine how they embody and reflect underlying power structures (Fairclough, 1989). More narrowly, it has been defined as having an explicit political aim: to frame discourse in such a fashion as to impose a dichotomy between a more powerful group and a less powerful group, and to empower the less powerful group (Wodak &amp; Meyer, 2001). This narrower normative definition has a strong implied value judgment. As defined by van Dijk, Critical Discourse Analysis "is a type of discourse analytical research that primarily studies the way social power abuse, dominance, and inequality are enacted, reproduced, and resisted by text and talk in the social and political context. With such dissident research, critical discourse analysts take explicit position, and thus want to understand, expose, and ultimately resist social inequality"(van Dijk, 1993)

Formation of thermodynamically unstable calcium oxalate dihydrate in sugar mill evaporators

Calcium oxalate (CaOX) is the most intractable scale component to remove in sugar mill evaporators by either mechanical or chemical means. The operating conditions of sugar mill evaporators should preferentially favour the formation of the thermodynamically stable calcium oxalate monohydrate (COM), yet analysis of scale deposit from different sugar factories have shown that calcium oxalate dihydrate (COD) is usually the predominant phase, and in some cases is the only hydrate formed. The effects of trans-aconitic, succinic and acetic acids, all of which are present in sugarcane juice, and ethylenediamine tetraacetic acid disodium salt (EDTA) on the growth of CaOX crystals have been examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray powder diffraction (XRD) and thermogravimetric analysis (TGA). trans-Aconitic acid, which constitutes two-thirds of the organic acid component in sugarcane juice, in the presence of sugar resulted in the formation of COD and COM in a 3:1 ratio. EDTA was the most effective acid to promote the formation of COD followed by trans-aconitic acid, then acetic acid and lastly succinic acid

A comparative study of novel scale inhibitors with commercial scale inhibitors used in seawater desalination

Seawater from the Arabian Gulf was heated under conditions simulating those of thermal desalination processes and the change in the amount of aquated Ca²+ followed over time using Inductively Coupled Plasma/Optical Emission Spectroscopy. This was done in the absence of any scale inhibitor, and in the presence of scale inhibitors: three commercial polycarboxylate products commonly employed in thermal desalination plants and four novel poly(acrylic acid) inhibitors of differing molar masses and end-group functionality. At times &gt; 2 min, the novel poly(acrylic acid) scale inhibitors of low (~ 2000) molar mass and moderate (hexyl isobutyrate or cyclohexyl isobutyrate) end-group hydrophobicity were more effective in maintaining the aquated Ca²+ level than any commercial product