2,318 research outputs found
L1-determined ideals in group algebras of exponential Lie groups
A locally compact group is said to be -regular if the natural map
\Psi:\Prim C^\ast(G)\to\Prim_{\ast} L^1(G) is a homeomorphism with respect to
the Jacobson topologies on the primitive ideal spaces \Prim C^\ast(G) and
\Prim_{\ast} L^1(G). In 1980 J. Boidol characterized the -regular ones
among all exponential Lie groups by a purely algebraic condition. In this
article we introduce the notion of -determined ideals in order to discuss
the weaker property of primitive -regularity. We give two sufficient
criteria for closed ideals of to be -determined. Herefrom
we deduce a strategy to prove that a given exponential Lie group is primitive
-regular. The author proved in his thesis that all exponential Lie groups
of dimension have this property. So far no counter-example is known.
Here we discuss the example , the only critical one in dimension
Effect of a second generation alpha2delta ligand, pregabalin on visceral sensation: a randomised controlled pilot study.
Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids
Most clinically used opioids are thought to induce analgesia through activation of the mu opioid receptor (MOR). However, disparities have been observed between the efficacy of opioids in activating the MOR in vitro and in inducing analgesia in vivo. In addition, some clinically used opioids do not produce cross-tolerance with each other, and desensitization produced in vitro does not match tolerance produced in vivo. These disparities suggest that some opioids could be acting through other targets in vivo, but this has not been comprehensively tested. We thus screened 9 clinically relevant opioids (buprenorphine, hydrocodone, hydromorphone, morphine, 0-desmethyl-tramadol, oxycodone, oxymorphone, tapentadol, tramadol) against 9 pain-related receptor targets (MOR, delta opioid receptor [DOR], kappa opioid receptor [KOR], nociceptin receptor [NOP], cannabinoid receptor type 1 [CB1], sigma-1 receptor [al R], and the monoamine transporters [NET/SERT/DAT]) expressed in cells using radioligand binding and functional activity assays. We found several novel interactions, including monoamine transporter activation by buprenorphine and al R binding by hydrocodone and tapentadol. Tail flick anti-nociception experiments with CD-1 mice demonstrated that the monoamine transporter inhibitor duloxetine selectively promoted buprenorphine anti-nociception while producing no effects by itself or in combination with the most MOR-selective drug oxymorphone, providing evidence that these novel interactions could be relevant in vivo. Our findings provide a comprehensive picture of the receptor interaction profiles of clinically relevant opioids, which has not previously been performed. Our findings also suggest novel receptor interactions for future investigation that could explain some of the disparities observed between opioid performance in vitro and in vivo.Depomed, Inc.; University of ArizonaOpen access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Recoil Correction to Hydrogen Energy Levels: A Revision
Recent calculations of the order (Z\alpha)^4(m/M)Ry pure recoil correction to
hydrogen energy levels are critically revised. The origins of errors made in
the previous works are elucidated. In the framework of a successive approach,
we obtain the new result for the correction to S levels. It amounts to -16.4
kHz in the ground state and -1.9 kHz in the 2S state.Comment: 15 pages, Latex, no figure
General Framework for phase synchronization through localized sets
We present an approach which enables to identify phase synchronization in
coupled chaotic oscillators without having to explicitly measure the phase. We
show that if one defines a typical event in one oscillator and then observes
another one whenever this event occurs, these observations give rise to a
localized set. Our result provides a general and easy way to identify PS, which
can also be used to oscillators that possess multiple time scales. We
illustrate our approach in networks of chemically coupled neurons. We show that
clusters of phase synchronous neurons may emerge before the onset of phase
synchronization in the whole network, producing a suitable environment for
information exchanging. Furthermore, we show the relation between the localized
sets and the amount of information that coupled chaotic oscillator can
exchange
Surviving the Ship Airwake: Towards a Scalable Turbulence Response Model For the Helicopter-Ship Dynamic Interface
On the Complex Network Structure of Musical Pieces: Analysis of Some Use Cases from Different Music Genres
This paper focuses on the modeling of musical melodies as networks. Notes of
a melody can be treated as nodes of a network. Connections are created whenever
notes are played in sequence. We analyze some main tracks coming from different
music genres, with melodies played using different musical instruments. We find
out that the considered networks are, in general, scale free networks and
exhibit the small world property. We measure the main metrics and assess
whether these networks can be considered as formed by sub-communities. Outcomes
confirm that peculiar features of the tracks can be extracted from this
analysis methodology. This approach can have an impact in several multimedia
applications such as music didactics, multimedia entertainment, and digital
music generation.Comment: accepted to Multimedia Tools and Applications, Springe
Positronium S state spectrum: analytic results at O(m alpha^6)
We present an analytic calculation of the O(m alpha^6) recoil and radiative
recoil corrections to energy levels of positronium nS states and their
hyperfine splitting. A complete analytic formula valid to O(m alpha^6) is given
for the spectrum of S states. Technical aspects of the calculation are
discussed in detail. Theoretical predictions are given for various energy
intervals and compared with experimental results.Comment: 29 pages, revte
Evolving networks with disadvantaged long-range connections
We consider a growing network, whose growth algorithm is based on the
preferential attachment typical for scale-free constructions, but where the
long-range bonds are disadvantaged. Thus, the probability to get connected to a
site at distance is proportional to , where is a
tunable parameter of the model. We show that the properties of the networks
grown with are close to those of the genuine scale-free
construction, while for the structure of the network is vastly
different. Thus, in this regime, the node degree distribution is no more a
power law, and it is well-represented by a stretched exponential. On the other
hand, the small-world property of the growing networks is preserved at all
values of .Comment: REVTeX, 6 pages, 5 figure
Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein
Progressive accumulation of the amyloid β protein in extracellular plaques is a neuropathological hallmark of Alzheimer disease. Amyloid β is generated during sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. In addition to the proteolytic processing by secretases, APP is also metabolized by lysosomal proteases. Here, we show that accumulation of intracellular sphingosine-1-phosphate (S1P) impairs the metabolism of APP. Cells lacking functional S1P-lyase, which degrades intracellular S1P, strongly accumulate full-length APP and its potentially amyloidogenic C-terminal fragments (CTFs) as compared with cells expressing the functional enzyme. By cell biological and biochemical methods, we demonstrate that intracellular inhibition of S1P-lyase impairs the degradation of APP and CTFs in lysosomal compartments and also decreases the activity of γ-secretase. Interestingly, the strong accumulation of APP and CTFs in S1P-lyase-deficient cells was reversed by selective mobilization of Ca(2+) from the endoplasmic reticulum or lysosomes. Intracellular accumulation of S1P also impairs maturation of cathepsin D and degradation of Lamp-2, indicating a general impairment of lysosomal activity. Together, these data demonstrate that S1P-lyase plays a critical role in the regulation of lysosomal activity and the metabolism of APP
- …