The triune brain: limbic mind, mind plastic, emotional mind

Problem statement: The theory discussed is revealing, as compared to studies on the human brain, the fact that he has inherited the structure and organization of three fundamental types of reptiles, ancient or primitive mammals and mammals, or recent evolved. What is very disconcerting is that nature has been able to connect with each other and establish a sort of communication between them. Approach: The objective was to focus the study on chemical substances that regulate the activity of nerve cells, neurons. We can define neuromodulators or modulators of behavior because their intervention more or less obvious influence our own actions. The method under consideration is the TMS, transcranial magnetic stimulation, a noninvasive technique of Neurostimulation and neuromodulation which is based on a type of electromagnetic induction of an electric field. Results: This property of TMS allows us to understand the precise moment when a brain region contributes to a certain task, to map the functional connectivity between different brain regions, to identify the causal relationships involved far treated between brain, cognition and behavior. Conclusion: It 'as certain that the thoughts and experience change the configuration of our brain connections, but so can the induced systems, based on the same principle, capable of altering particularly for therapeutic, rehabilitative or educational, the brain matter on the basis of premises of the so-called phenomenon called Hebbian learning based on chemical changes in the cells and synapses known as long-term potentiation

The Network Building Capacity of Tourist Districts: An Application to the Apulian Case

The research reported in this study sought to determine whether successful tourist destinations can build a «network» on the basis of their attractiveness. To this end, we conducted a social network analysis with municipalities as network nodes and edges representing the natural, economic, social, and public institutional dimensions, reduced to a composite attractiveness indicator (CAI). Although easily replicable in other contexts, our methodology was tested on two Apulian areas in Southern Italy, Gargano and Salento, which are legally designated as tourist districts. The analysis emphasizes that these districts are still unable to construct a system despite strong potential in terms of attractiveness

Emotional Competence and Affective Computing as Factors of Formation of Individual and Social Identity

This experience of psycho-emotional education is part of more extensive international researches based on the hypothesis that the “emotional experience”, if inserted in the daily conduct of the school curriculum, especially in the nursery school one, represents an excellent training opportunity, since it fosters the learners' best perception of the self, thus strengthening their expressive and communicative attitude. On the basis of Social and Emotional Learning (SEL) principles and inspired by a previous experience carried out by the Department of Human Science for training, this experimental project has been put into practice by some nursery schools in RC, thus providing very interesting data for the confirmation of the hypothesis. It has been also developed a study on the affective computing and the cognitive computing pursuing a new perspective that exceeds the traditional vision of what is defined as artificial intelligence and analyzes intelligence and aspects of perceptions, often neglected, with a methodological approach considering the emotional processes as important as the cognitive ones

Il modellaggio: una forma di apprendimento semplessa per acquisire “nuove” abilità

The research is aimed to analyze a technique and a learning approach, in particular, based on the shaping of the behavioral responses able to face up simplex situations (Berthoz, 2011) linked to conditions of disability and SEN (Special Educational Needs).After having focused on the fundamental principles of behavior, it has been analyzed the concept of reinforcement. The reinforcement is the effect that follows a certain behavior, and that determinesthe probability that the behavior can be performed, so that it can be considered a necessary and sufficient condition to trigger the mechanisms of learning. In fact, a good methodology to individualize teaching should be based firstly on the constructionof “new” skills, totally absent in a subject, starting from the reinforcement of behaviors that are similar to that ability and continuing to reinforce successive approximations of those behaviors.When a person with disability, or with mild to medium-severe difficulties is able to master an initialresponse, all the successive approximations to the target behavior are progressively reinforced

The Enactive Didactics for Enactive Mind:The Evolution of a Learning Model

The term "enactive mind " comes from the Varela work and the concept of "activation " underlines. Approach you enactive involves two concepts: from a side than the perception he consists in an action to his time driven by the perception coming from that action date and from the other but the cognitive structures they emerge from the recurring sensory- motor schemes which allow the action to be perceptively driven. In the specific one, approach him EM places like a frame to frame a series of phenomena considered essential for the comprehension of the concept of adaptation as social as the necessity of considering the relation world complexity as, the importing time constraints present in it, the nature and the modes in which mechanisms of this adaptation allow the formation of the social knowledge. In the EM approach the child "activates the social world " selectively perceiving it in the terms of what which is immediately essential for a social action, while the mental representations (the social knowledge) of this individualized world build themselves based on the repeated experiences ripened by these actions driven by the perception, become then deeply you root in the history of relational actions of the child to be tools for the adaptation to the world in which alive. The enactive vision, although it recalls in the meaning the concept of representation as mode to know, tries to exceed it in favor of the corporeality, that is an incorporate mind (embodied mind). A corollary of this theory is that subject

Cotard’s Syndrome: Clinical Case Presentation and Literature Review

In 1880 French neurologist Jules Cotard described a condition characterized by delusion of negation (nihilistic delusion) in a melancholia context. Recently, there has been a resurgence of interest in Cotard’s syndrome. The most prominent symptoms of Cotard’s Syndrome are depressive mood, nihilistic delusions concerning one’s own body and one’s own existence, delusions of guilt, immortality and hypochondria. The aim of the present paper is to review literature evidences concerning Cotard’s syndrome and to describe a clinical case keeping in the background the recent trends on its psychopathological implications. In the clinical study, the following sequence of stages emerged: the dissociative side, expressed as a loss of body-mind cohesion; the ‘mixed’ mood disorder, with depressive-manic episodes, and a persecutory background, all coexisting in the anguish of the idea of a body falling apart, the anguish of a descent towards the abyss of melancholia and/or an ascent to unlimited euphoria, characteristic of an “uncommon alarm” for loss of Self cohesion

Role of HMGB1 as a suitable biomarker of subclinical intestinal inflammation and mucosal healing in patients with inflammatory bowel disease

BACKGROUND: Noninvasive biomarkers of high- and low-grade intestinal inflammation and of mucosal healing (MH) in patients with inflammatory bowel disease are currently lacking. We have recently shown that fecal high mobility group box 1 (HMGB1) protein is a novel biomarker of gut inflammation. We aimed at investigating in a mouse model if HMGB1 was able to foresee both a clinically evident and a subclinical gut inflammation and if its normalization indicated MH. We also aimed at confirming the results in patients with Crohn's disease (CD) and ulcerative colitis. METHODS: C57BL6/J mice were treated with increasing doses of dextran sodium sulphate to induce colitis of different severity degrees; 28 with CD, 23 with ulcerative colitis, and 17 controls were also enrolled. Fecal HMGB1 was analyzed by enzyme-linked immunosorbent assay and immunoblotting. RESULTS: Fecal HMGB1 increased by 5-, 11-, 18-, and 24-folds with dextran sodium sulphate doses of 0.25%, 0.50%, 1%, and 4%, respectively, showing that the protein detected a high-grade and a subclinical inflammation. After a recovery time of 4-week posttreatment, HMGB1 returned to control levels, paralleling MH. In patients, fecal HMGB1 significantly correlated with endoscopic indexes (Simple Endoscopic Score for Crohn's Disease [SES-CD], endoscopic Mayo subscore), but not with the disease activity indexes (Crohn's disease Activity Index, partial Mayo score). CONCLUSIONS: Fecal HMGB1 is a robust noninvasive biomarker of clinically overt and subclinical gut inflammation; it can also be a surrogate marker of MH. We suggest the use of fecal HMGB1 to monitor the disease course and assess therapy outcomes in inflammatory bowel diseaseBACKGROUND: Noninvasive biomarkers of high- and low-grade intestinal inflammation and of mucosal healing (MH) in patients with inflammatory bowel disease are currently lacking. We have recently shown that fecal high mobility group box 1 (HMGB1) protein is a novel biomarker of gut inflammation. We aimed at investigating in a mouse model if HMGB1 was able to foresee both a clinically evident and a subclinical gut inflammation and if its normalization indicated MH. We also aimed at confirming the results in patients with Crohn's disease (CD) and ulcerative colitis. METHODS: C57BL6/J mice were treated with increasing doses of dextran sodium sulphate to induce colitis of different severity degrees; 28 with CD, 23 with ulcerative colitis, and 17 controls were also enrolled. Fecal HMGB1 was analyzed by enzyme-linked immunosorbent assay and immunoblotting. RESULTS: Fecal HMGB1 increased by 5-, 11-, 18-, and 24-folds with dextran sodium sulphate doses of 0.25%, 0.50%, 1%, and 4%, respectively, showing that the protein detected a high-grade and a subclinical inflammation. After a recovery time of 4-week posttreatment, HMGB1 returned to control levels, paralleling MH. In patients, fecal HMGB1 significantly correlated with endoscopic indexes (Simple Endoscopic Score for Crohn's Disease [SES-CD], endoscopic Mayo subscore), but not with the disease activity indexes (Crohn's disease Activity Index, partial Mayo score). CONCLUSIONS: Fecal HMGB1 is a robust noninvasive biomarker of clinically overt and subclinical gut inflammation; it can also be a surrogate marker of MH. We suggest the use of fecal HMGB1 to monitor the disease course and assess therapy outcomes in inflammatory bowel diseas