1,570 research outputs found
PSS50 TRENDS IN MEDICATION PRESCRIBING FOR ACNE IN THE UNITED STATES ACCORDING TO PATIENT AGE
PSS56 PRESCRIPTION REFILLS AND HEALTH CARE COSTS ASSOCIATED WITH TOPICAL METRONIDAZOLE IN MEDICAID ENROLLED PATIENTS WITH ROSACEA
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Gentian violet for pyoderma gangrenosum: a retrospective chart review
Pyoderma gangrenosum is a rare autoinflammatory skin disease. Treatment is multifactorial, addressing inflammation, pain, underlying disease, if present, and the wound. Gentian violet has been used for hundreds of years in a variety of dermatologic conditions for its anti-inflammatory properties. This study aims to evaluate gentian violet in wound healing for pyoderma gangrenosum. We conducted a retrospective chart review of patients with pyoderma gangrenosum treated with gentian violet at the Wake Forest School of Medicine Department of Dermatology in the last 10 years. The primary outcome was clinical improvement. Of the 34 cases that met inclusion criteria, 70% improved with gentian violet, 24% had no documented change, 3% initially improved then worsened, and 3% had unclear results. Gentian violet is a safe and cheap treatment that may improve resolution of pyoderma gangrenosum lesions in addition to systemic therapy
PSS11 MEDICATION CHOICE AND ASSOCIATED HEALTH-CARE OUTCOMES AND COSTS FOR PATIENTS WITH PSORIASIS IN THE UNITED STATES
PSK3 “HEALTH BENEFIT LIMITS” LIMIT TREATMENT OF PSORIASIS AND OTHER DERMATOLOGICAL CONDITIONS
Evaluation of efalizumab using safe psoriasis control
BACKGROUND: Safe Psoriasis Control (SPC) is an important comprehensive measure that is validated for the assessment of benefit:risk of psoriasis treatments, combining efficacy, quality of life, and safety measures. The objective of this analysis was to assess the benefit:risk of efalizumab, a novel biologic agent indicated for the treatment of moderate-to-severe plaque psoriasis, by applying the SPC to data from randomized, placebo-controlled clinical studies of efalizumab. METHODS: SPC was applied to week 12 data from four placebo-controlled, Phase III studies: three retrospective and one prospective, the latter including a cohort of "high-need" patients for whom existing therapies were inadequate or unsuitable. RESULTS: In the retrospective analysis, 39.4% of patients achieved SPC after 12 weeks of treatment with efalizumab, compared with 10.4% for placebo. In the prospective analysis, 34.3% of patients achieved SPC after 12 weeks of treatment with efalizumab, compared with 7.3% on placebo. Among high-need patients, 33.0% achieved SPC, compared with 3.4% on placebo. CONCLUSION: Efalizumab has a favorable benefit:risk profile using the comprehensive outcome measure SPC
PSK2 PHYSICIAN AND PATIENT RELATED DETERMINANTS OF PRESCRIBING TOPICAL CALCINEURIN INHIBITORS FOR PATIENTS WITH ATOPIC DERMATITIS: ANALYSIS OF U.S. NATIONAL OUTPATIENTVISIT DATA
Sociomateriality Implications of Software As a Service Adoption on IT-workers’ Roles and Changes in Organizational Routines of IT Systems Support
This paper aims to deepen our understanding on how sociomateriality practices influence IT
workers’ roles and skill set requirements and changes to the organizational routines of IT systems support,
when an organization migrates an on-premise IT system to a software as a service (SaaS) model. This
conceptual paper is part of an ongoing study investigating organizations that migrated on-premise IT email
systems to SaaS business models, such as Google Apps for Education (GAE) and Microsoft Office 365
systems, in New Zealand tertiary institutions. We present initial findings from interpretive case studies. The
findings are, firstly, technological artifacts are entangled in sociomaterial practices, which change the way
humans respond to the performative aspects of the organizational routines. Human and material agencies are
interwoven in ways that reinforce or change existing routines. Secondly, materiality, virtual realm and spirit
of the technology provide elementary levels at which human and material agencies entangle. Lastly, the
elementary levels at which human and material entangle depends on the capabilities or skills set of an
individual
Development and validation of a questionnaire for analyzing real-life falls in long-term care captured on video
Interpreting the results of patient reported outcome measures in clinical trials: The clinician's perspective
This article deals with the problem of interpreting health-related quality of life (HRQL) outcomes in clinical trials. First, we will briefly describe how dichotomization and item response theory can facilitate interpretation. Based on examples from the medical literature for the interpretation of HRQL scores we will show that dichotomies may help clinicians understand information provided by HRQL instruments in RCTs. They can choose thresholds to calculate proportions of patients benefiting based on absolute scores or change scores. For example, clinicians interpreting clinical trial results could consider the difference in the proportion of patients who achieve a mean score of 50 before and after an intervention on a scale from 1 to 100. For the change score approach, they could consider the proportion of patients who have changed by a score of 5 or more. Finally, they can calculate the proportion of patients benefiting and transform these numbers into a number needed to treat or natural frequencies. Second, we will describe in more detail an approach to the interpretation of HRQL scores based on the minimal important difference (MID) and proportions. The MID is the smallest difference in score in the outcome of interest that informed patients or informed proxies perceive as important, either beneficial or harmful, and that would lead the patient or clinician to consider a change in the management. Any change in management will depend on the downsides, including cost and inconvenience, associated with the intervention. Investigators can help with the interpretation of HRQL scores by determining the MID of an HRQL instrument and provide mean differences in relation to the MID. For instance, for an MID of 0.5 on a seven point scale investigators could provide the mean change on the instrument as well as the proportion of patients with scores greater than the MID. Thus, there are several steps investigators can take to facilitate this process to help bringing HRQL information closer to the bedside
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