mRNA Coronavirus Disease 2019 Vaccine-Associated Myopericarditis in Adolescents: A Survey Study

In this survey study of institutions across the US, marked variability in evaluation, treatment, and follow-up of adolescents 12 through 18 years of age with mRNA coronavirus disease 2019 (COVID-19) vaccine-associated myopericarditis was noted. Only one adolescent with life-threatening complications was reported, with no deaths at any of the participating institutions

2003 Rockefeller New Media Foundation Proposal

This project will take as its primary point of departure my most recent works in which artificially "intelligent", computerdriven lifelike silicone heads are engaged in improvisational conversations. The conversations which they carry on are neither completely scripted, nor are they random; rather, the software I have written gives each a "personality", a vocabulary, associative habits, obsessions, and other peculiarities, which make their conversations quirky, surprising, and often startling. They also intend to raise questions about computer intelligence and intelligence (and consciousness) itself

Artist Installation Diagram

Artist Installation Diagra

Aerosol-cloud-climate cooling overestimated by ship-track data

The effect of anthropogenic aerosol on the reflectivity of stratocumulus cloud decks through changes in cloud amount is a major uncertainty in climate projections. In frequently occurring nonprecipitating stratocumulus, cloud amount can decrease through aerosol-enhanced cloud-top mixing. The climatological relevance of this effect is debated because ship exhaust only marginally reduces stratocumulus amount. By comparing detailed numerical simulations with satellite analyses, we show that ship-track studies cannot be generalized to estimate the climatological forcing of anthropogenic aerosol. The ship track-derived sensitivity of the radiative effect of nonprecipitating stratocumulus to aerosol overestimates their cooling effect by up to 200%. The offsetting warming effect of decreasing stratocumulus amount needs to be taken into account if we are to constrain the cloud-mediated radiative forcing of anthropogenic aerosol.Accepted Author ManuscriptAtmospheric Remote Sensin

Gaussian-process emulation for integrating data-driven aerosol-cloud physics from simulation, satellite, and ground-based data

Data-driven quantification and parameterization of cloud physics in general, and of aerosol-cloud interactions in particular, rely on input data from observations or detailed simulations. These data sources have complementary limitations in terms of their spatial and temporal coverage and resolution; simulation data has the advantage of readily providing causality but cannot represent the full process complexity. In order to base data-driven approaches on comprehensive information, we therefore need ways to integrate different data sources. We discuss how the classical statistical technique of Gaussian-process emulation can be combined with specifically initialized ensembles of detailed cloud simulations (large-eddy simulations, LES) to provide a framework for evaluating data-driven descriptions of cloud characteristics and processes across different data sources. We specifically illustrate this approach for integrating LES and satellite data of aerosol-cloud interactions in subtropical stratocumulus cloud decks. We furthermore explore the extension of our framework to ground-based observations of Arctic mixed-phase clouds.Atmospheric Remote Sensin

Targeted deletion of endothelial lipase increases HDL particles with anti-inflammatory properties both in vitro and in vivo

Previous studies have shown that targeted deletion of endothelial lipase (EL) markedly increases the plasma high density lipoprotein cholesterol (HDL-C) level in mice. However, little is known about the functional quality of HDL particles after EL inhibition. Therefore, the present study assessed the functional quality of HDL isolated from EL−/− and wild-type (WT) mice. Anti-inflammatory functions of HDL from EL−/− and WT mice were evaluated by in vitro assays. The HDL functions such as PON-1 or PAF-AH activities, inhibition of cytokine-induced vascular cell adhesion molecule-1 expression, inhibition of LDL oxidation, and the ability of cholesterol efflux were similar in HDL isolated from WT and EL−/− mice. In contrast, the lipopolysaccharide-neutralizing capacity of HDL was significantly higher in EL−/− mice than that in WT mice. To evaluate the anti-inflammatory actions of HDL in vivo, lipopolysaccharide-induced systemic inflammation was generated in these mice. EL−/− mice showed higher survival rate and lower expression of inflammatory markers than WT mice. Intravenous administration of HDL isolated from EL−/− mice significantly improved the mortality after lipopolysaccharide injection in WT mice. In conclusion, targeted disruption of EL increased HDL particles with preserved anti-inflammatory and anti-atherosclerotic functions. Thus, EL inhibition would be a useful strategy to raise ‘good’ cholesterol in the plasma