406 research outputs found
CompRRAE: RRAM-based Convolutional Neural Network Accelerator with Reduced Computations through a Runtime Activation Estimation
Recently Resistive-RAM (RRAM) crossbar has been used in the design of the
accelerator of convolutional neural networks (CNNs) to solve the memory wall
issue. However, the intensive multiply-accumulate computations (MACs) executed
at the crossbars during the inference phase are still the bottleneck for the
further improvement of energy efficiency and throughput. In this work, we
explore several methods to reduce the computations for the RRAM-based CNN
accelerators. First, the output sparsity resulting from the widely employed
Rectified Linear Unit is exploited, and a significant portion of computations
are bypassed through an early detection of the negative output activations.
Second, an adaptive approximation is proposed to terminate the MAC early when
the sum of the partial results of the remaining computations is considered to
be within a certain range of the intermediate accumulated result and thus has
an insignificant contribution to the inference. In order to determine these
redundant computations, a novel runtime estimation on the maximum and minimum
values of each output activation is developed and used during the MAC
operation. Experimental results show that around 70% of the computations can be
reduced during the inference with a negligible accuracy loss smaller than 0.2%.
As a result, the energy efficiency and the throughput are improved by over 2.9
and 2.8 times, respectively, compared with the state-of-the-art RRAM-based
accelerators.Comment: 7 pages, 6 figures, Accepted by ASP-DAC 201
Irradiation of Materials with Short, Intense Ion pulses at NDCX-II
We present an overview of the performance of the Neutralized Drift
Compression Experiment-II (NDCX-II) accelerator at Berkeley Lab, and report on
recent target experiments on beam driven melting and transmission ion energy
loss measurements with nanosecond and millimeter-scale ion beam pulses and thin
tin foils. Bunches with around 10^11 ions, 1-mm radius, and 2-30 ns FWHM
duration have been created with corresponding fluences in the range of 0.1 to
0.7 J/cm^2. To achieve these short pulse durations and mm-scale focal spot
radii, the 1.1 MeV He+ ion beam is neutralized in a drift compression section,
which removes the space charge defocusing effect during final compression and
focusing. The beam space charge and drift compression techniques resemble
necessary beam conditions and manipulations in heavy ion inertial fusion
accelerators. Quantitative comparison of detailed particle-in-cell simulations
with the experiment play an important role in optimizing accelerator
performance.Comment: 15 pages, 7 figures. revised manuscript submitted to Laser and
Particle Beam
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Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged. Haematopoiesis provides a well-defined model to study epigenetic modifications during cell-fate decisions, as multipotent progenitors (MPPs) differentiate into progressively restricted myeloid or lymphoid progenitors. Although DNA methylation is critical for myeloid versus lymphoid differentiation, as demonstrated by the myeloerythroid bias in Dnmt1 hypomorphs, a comprehensive DNA methylation map of haematopoietic progenitors, or of any multipotent/oligopotent lineage, does not exist. Here we examined 4.6 million CpG sites throughout the genome for MPPs, common lymphoid progenitors (CLPs), common myeloid progenitors (CMPs), granulocyte/macrophage progenitors (GMPs), and thymocyte progenitors (DN1, DN2, DN3). Marked epigenetic plasticity accompanied both lymphoid and myeloid restriction. Myeloid commitment involved less global DNA methylation than lymphoid commitment, supported functionally by myeloid skewing of progenitors following treatment with a DNA methyltransferase inhibitor. Differential DNA methylation correlated with gene expression more strongly at CpG island shores than CpG islands. Many examples of genes and pathways not previously known to be involved in choice between lymphoid/myeloid differentiation have been identified, such as Arl4c and Jdp2. Several transcription factors, including Meis1, were methylated and silenced during differentiation, indicating a role in maintaining an undifferentiated state. Additionally, epigenetic modification of modifiers of the epigenome seems to be important in haematopoietic differentiation. Our results directly demonstrate that modulation of DNA methylation occurs during lineage-specific differentiation and defines a comprehensive map of the methylation and transcriptional changes that accompany myeloid versus lymphoid fate decisions
Topological Dislocations and Mixed State of Charge Density Waves
We discuss the possibility of the ``mixed state'' in incommensurate charge
density waves with three-dimensional order. It is shown that the mixed state
can be created by applying an electric field perpendicular to the chains. This
state consists of topological dislocations induced by the external field and is
therefore similar to the mixed states of superfluids (type-II superconductor or
liquid Helium II). However, the peculiar coupling of charge density waves with
the electric field strongly modifies the nature of the mixed state compared to
the conventional superfluids. The field and temperature dependence of the
properties of the mixed state are studied, and some experimental aspects are
discussed.Comment: 10 pages, Revtex format, no figures, to appear in Phys. Rev. Let
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Epigenetic memory in induced pluripotent stem cells.
Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. Through different mechanisms and kinetics, these two reprogramming methods reset genomic methylation, an epigenetic modification of DNA that influences gene expression, leading us to hypothesize that the resulting pluripotent stem cells might have different properties. Here we observe that low-passage induced pluripotent stem cells (iPSCs) derived by factor-based reprogramming of adult murine tissues harbour residual DNA methylation signatures characteristic of their somatic tissue of origin, which favours their differentiation along lineages related to the donor cell, while restricting alternative cell fates. Such an 'epigenetic memory' of the donor tissue could be reset by differentiation and serial reprogramming, or by treatment of iPSCs with chromatin-modifying drugs. In contrast, the differentiation and methylation of nuclear-transfer-derived pluripotent stem cells were more similar to classical embryonic stem cells than were iPSCs. Our data indicate that nuclear transfer is more effective at establishing the ground state of pluripotency than factor-based reprogramming, which can leave an epigenetic memory of the tissue of origin that may influence efforts at directed differentiation for applications in disease modelling or treatment
Parity-Violating Excitation of the \Delta(1232): Hadron Structure and New Physics
We consider prospects for studying the parity-violating (PV) electroweak
excitation of the \Delta(1232) resonance with polarized electron scattering.
Given present knowledge of Standard Model parameters, such PV experiments could
allow a determination of the N -> \Delta electroweak helicity amplitudes. We
discuss the experimental feasibility and theoretical interpretability of such a
determination as well as the prospective implications for hadron structure
theory. We also analyze the extent to which a PV N -> \Delta measurement could
constrain various extensions of the Standard Model.Comment: 43 pages, RevTex, 8 PS figures, uses epsf.sty, rotate.sty, version to
appear in Nucl. Phys. A, main points emphasized, some typos correcte
P-odd and CP-odd Four-Quark Contributions to Neutron EDM
In a class of beyond-standard-model theories, CP-odd observables, such as the
neutron electric dipole moment, receive significant contributions from
flavor-neutral P-odd and CP-odd four-quark operators. However, considerable
uncertainties exist in the hadronic matrix elements of these operators strongly
affecting the experimental constraints on CP-violating parameters in the
theories. Here we study their hadronic matrix elements in combined chiral
perturbation theory and nucleon models. We first classify the operators in
chiral representations and present the leading-order QCD evolutions. We then
match the four-quark operators to the corresponding ones in chiral hadronic
theory, finding symmetry relations among the matrix elements. Although this
makes lattice QCD calculations feasible, we choose to estimate the
non-perturbative matching coefficients in simple quark models. We finally
compare the results for the neutron electric dipole moment and P-odd and CP-odd
pion-nucleon couplings with the previous studies using naive factorization and
QCD sum rules. Our study shall provide valuable insights on the present
hadronic physics uncertainties in these observables.Comment: 40 pages, 7 figures. This is the final version. A discussion of the
uncertainty of the calculation is adde
Thermal photons in QGP and non-ideal effects
We investigate the thermal photon production-rates using one dimensional
boost-invariant second order relativistic hydrodynamics to find proper time
evolution of the energy density and the temperature. The effect of
bulk-viscosity and non-ideal equation of state are taken into account in a
manner consistent with recent lattice QCD estimates. It is shown that the
\textit{non-ideal} gas equation of state i.e behaviour
of the expanding plasma, which is important near the phase-transition point,
can significantly slow down the hydrodynamic expansion and thereby increase the
photon production-rates. Inclusion of the bulk viscosity may also have similar
effect on the hydrodynamic evolution. However the effect of bulk viscosity is
shown to be significantly lower than the \textit{non-ideal} gas equation of
state. We also analyze the interesting phenomenon of bulk viscosity induced
cavitation making the hydrodynamical description invalid. We include the
viscous corrections to the distribution functions while calculating the photon
spectra. It is shown that ignoring the cavitation phenomenon can lead to
erroneous estimation of the photon flux.Comment: 11 pages, 13 figures; accepted for publication in JHE
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