Control of transverse instability in rocket combustors Patent

Rocket combustion chamber stability by controlling transverse instability during propellant combustio

Evaluation of tangential velocity effects on spinning transverse combustion instability

Tangential velocity effects on spinning transverse combustion instabilit

Crystal Structure of a Ube2S-Ubiquitin Conjugate

Protein ubiquitination occurs through the sequential formation and reorganization of specific protein-protein interfaces. Ubiquitin-conjugating (E2) enzymes, such as Ube2S, catalyze the formation of an isopeptide linkage between the C-terminus of a “donor” ubiquitin and a primary amino group of an “acceptor” ubiquitin molecule. This reaction involves an intermediate, in which the C-terminus of the donor ubiquitin is thioester-bound to the active site cysteine of the E2 and a functionally important interface is formed between the two proteins. A docked model of a Ube2S-donor ubiquitin complex was generated previously, based on chemical shift mapping by NMR, and predicted contacts were validated in functional studies. We now present the crystal structure of a covalent Ube2S-ubiquitin complex. The structure contains an interface between Ube2S and ubiquitin in trans that resembles the earlier model in general terms, but differs in detail. The crystallographic interface is more hydrophobic than the earlier model and is stable in molecular dynamics (MD) simulations. Remarkably, the docked Ube2S-donor complex converges readily to the configuration seen in the crystal structure in 3 out of 8 MD trajectories. Since the crystallographic interface is fully consistent with mutational effects, this indicates that the structure provides an energetically favorable representation of the functionally critical Ube2S-donor interface

New frontiers at the interface of general relativity and quantum optics

In the present paper we follow three major themes: (i) concepts of rotation in general relativity, (ii) effects induced by these generalized rotations, and (iii) their measurement using interferometry. Our journey takes us from the Foucault pendulum via the Sagnac interferometer to manifestations of gravito-magnetism in double binary pulsars and in Gödel\u27s Universe. Throughout our article we emphasize the emerging role of matter wave interferometry based on cold atoms or Bose-Einstein condensates leading to superior inertial sensors. In particular, we advertise recent activities directed towards the operation of a coherent matter wave interferometer in an extended free fall. © 2009 Springer Science+Business Media B.V

Arecibo Timing and Single Pulse Observations of 18 Pulsars

We present new results of timing and single pulse measurements for 18 radio pulsars discovered in 1993 - 1997 by the Penn State/NRL declination-strip survey conducted with the 305-m Arecibo telescope at 430 MHz. Long-term timing measurements have led to significant improvements of the rotational and the astrometric parameters of these sources, including the millisecond pulsar, PSR J1709+2313, and the pulsar located within the supernova remnant S147, PSR J0538+2817. Single pulse studies of the brightest objects in the sample have revealed an unusual "bursting" pulsar, PSR J1752+2359, two new drifting subpulse pulsars, PSR J1649+2533 and PSR J2155+2813, and another example of a pulsar with profile mode changes, PSR J1746+2540. PSR J1752+2359 is characterized by bursts of emission, which appear once every 3-5 min. and decay exponentially on a ~45 sec timescale. PSR J1649+2533 spends ~30% of the time in a null state with no detectable radio emission.Comment: submitted to Ap

Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage

Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood. Matrix metalloproteinase (MMP)-9 is held responsible for the degradation of microvascular basal lamina proteins leading to blood-brain barrier dysfunction and, thus, formation of vasogenic cerebral edema. The current study was conducted to clarify the role of MMP-9 for the development of cerebral edema and for functional outcome after SAH. Methods: SAH was induced in FVB/N wild-type (WT) or MMP-9 knockout (MMP-9(-/-)) mice by endovascular puncture. Intracranial pressure (ICP), regional cerebral blood flow (rCBF), and mean arterial blood pressure (MABP) were continuously monitored up to 30 min after SAH. Mortality was quantified for 7 days after SAH. In an additional series neurological function and body weight were assessed for 3 days after SAH. Subsequently, ICP and brain water content were quantified. Results: Acute ICP, rCBF, and MABP did not differ between WT and MMP-9(-/-) mice, while 7 days' mortality was lower in MMP-9(-/-) mice (p = 0.03; 20 vs. 60%). MMP-9(-/-) mice also exhibited better neurological recovery, less brain edema formation, and lower chronic ICP. Conclusions: The results of the current study suggest that MMP-9 contributes to the development of early brain damage after SAH by promoting cerebral edema formation. Hence, MMP-9 may represent a novel molecular target for the treatment of SAH. Copyright (C) 2011 S. Karger AG, Base