Vibration analysis of three-DOF motor with liquid suspension based on fluid-solid coupling

Based on the combination of elastohydrodynamic lubrication and contact deformation theory, i.e. fluid-solid coupling theory, and considering the surface roughness of stator and rotor, a three-degree-of-freedom vibration model of spherical bearings with spiral grooves is established. The finite difference method is used to calculate and analyze the distribution of lubricating film pressure, film thickness and the influence of eccentricity of rotor on film pressure. Combining the stiffness of lubricating oil film with the finite element method, the displacement, stator vibration speed, acceleration and displacement of lubricating oil film are calculated from the angle of elastic boundary, and compared with the slotless structure. The results show that the bearing capacity of lubricating oil film of spherical bearing is improved and the stability of continuous oil film is improved by adding spiral groove. Secondly, the vibration characteristics of stator and rotor with spiral groove structure are more in line with the viscoelastic periodic distribution law. The vibration stability of the system is improved. In order to further optimize the vibration stability of the motor, the theoretical basis is provided

Data-Driven Distributed Optical Vibration Sensors: A Review

Distributed optical vibration sensors (DOVS) have attracted much attention recently since it can be used to monitor mechanical vibrations or acoustic waves with long reach and high sensitivity. Phase-sensitive optical time domain reflectometry (Φ-OTDR) is one of the most commonly used DOVS schemes. For Φ-OTDR, the whole length of fiber under test (FUT) works as the sensing instrument and continuously generates sensing data during measurement. Researchers have made great efforts to try to extract external intrusions from the redundant data. High signal-to-noise ratio (SNR) is necessary in order to accurately locate and identify external intrusions in Φ-OTDR systems. Improvement in SNR is normally limited by the properties of light source, photodetector and FUT. But this limitation can also be overcome by post-processing of the received optical signals. In this context, detailed methodologies of SNR enhancement post-processing algorithms in Φ-OTDR systems have been described in this paper. Furthermore, after successfully locating the external vibrations, it is also important to identify the types of source of the vibrations. Pattern classification is a powerful tool in recognizing the intrusion types from the vibration signals in practical applications. Recent reports of Φ-OTDR systems employed with pattern classification algorithms are subsequently reviewed and discussed. This thorough review will provide a design pathway for improving the performance of Φ-OTDR while maintaining the cost of the system as no additional hardware is required

Catalytic liquefaction of sewage sludge to small molecular weight chemicals

The catalytic hydrotreatment of sewage sludge, the wet solid byproducts from wastewater treatment plants, using supported Ir, Pt, Pd, Ru catalysts had been investigated with different solvent conditions. Reactions were carried out in a batch set-up at elevated temperatures (400 °C) using a hydrogen donor (formic acid (FA) in isopropanol (IPA) or hydrogen gas), with sewage sludge obtained from different sampling places. Sewage sludge conversions of up to 83.72% were achieved using Pt/C, whereas the performance for the others catalysts is different and solvent had a strong effect on the conversion rate and product constitution. The sewage sludge oils were characterised using a range of analytical techniques (GC, GC–MS, GCxGC, GPC) and were shown to consist of monomers, mainly alkanes and higher oligomers

Flavor Wheel Development and Sensory Quantitative Descriptive Analysis of Chinese Brewed Soy Sauce

Based on sensory descriptors developed by a sensory evaluation panel for 48 commercial Chinese brewed soy sauce samples, a flavor wheel of Chinese brewed soy sauce with 55 descriptors in the dimensions of aroma and flavor was developed for the first time. Meanwhile, a lexicon of sensory descriptors for brewed soy sauce containing reference samples with different intensities was established, and 20 brewed soy sauce samples of different grades and from different geographical origins were subjected to sensory evaluation by quantitative descriptive analysis (QDA) using this lexicon. The results showed that the characteristic flavor attributes of soy sauce were soy paste-like, salty, umami, Chinese herbal, and cooked soybean-like aromas. Through analysis of variance (ANOVA), principal component analysis (PCA) and discriminant analysis (DA), it was found that there were significant differences in sensory properties among soy sauce of different grades and from different regions. This study can provide a methodological reference for sensory quality analysis of Chinese brewed soy sauce

RNF43 is associated with genomic features and clinical outcome in BRAF mutant colorectal cancer

BackgroundColorectal cancer (CRC) patients with BRAF mutation have very poor prognosis. It is urgent to search for prognostic factors of BRAF mutant CRC. RNF43 is a ENF ubiquitin ligase of Wnt signaling. Mutation of RNF43 has been observed frequently in various types of human cancers. However, few studies have evaluated the role of RNF43 in CRC. The present study aimed to explore the impact of RNF43 mutations on molecular characteristics and prognosis in BRAF mutant CRC.MethodsSamples of 261 CRC patients with BRAF mutation were retrospectively analyzed. Tumor tissue and matched peripheral blood samples were collected and subjected to targeted sequencing with a panel of 1021 cancer-related genes. The association of molecular characteristics and survival in patients were then analyzed. 358 CRC patients with BRAF mutation from the cBioPortal dataset were used for further confirmation.ResultsThis study was inspired by a CRC patient with BRAF V600E and RNF43 co-mutation, who achieved a best remission of 70% and a progression free survival (PFS) of 13 months. Genomic analysis indicated that RNF43 mutation affected the genomic characteristics of patients with BRAF mutation, including microsatellite instability (MSI), tumor mutation burden (TMB) and the proportion of common gene mutations. Survival analysis showed that RNF43 mutation was a predictive biomarker for better PFS and OS in BRAF mutant CRC.ConclusionCollectively, we identified that RNF43 mutations were correlated with favorable genomic features, resulting in a better clinical outcome for BRAF mutant CRC patients

Is the Core-cusp Problem a Matter of Perspective? Jeans Anisotropic Modeling against Numerical Simulations

Mock member stars for 28 dwarf galaxies are constructed from the cosmological auriga simulation, which reflects the dynamical status of realistic stellar tracers. Axisymmetric Jeans Anisotropic Multi-Gaussian Expansion (jam) modeling is applied to 6000 star particles for each system to recover the underlying matter distribution. The stellar or dark matter component individually is poorly recovered, but the total profile is constrained more reasonably. The mass within the half-mass radius of tracers is recovered the tightest, and the mass between 200 and 300 pc, M(200–300 pc), is an unbiasedly constrained ensemble, with a scatter of 0.167 dex. If using 2000 particles and only line-of-sight velocities with typical errors, the scatter in M(200–300 pc) is increased by ∼50%. Quiescent Saggitarius dSph–like systems and star-forming systems with strong outflows show distinct features, with M(200–300 pc) mostly underestimated for the former, and likely overestimated for the latter. The biases correlate with the dynamical status, which is a result of contraction motions due to tidal effects in quiescent systems or galactic winds in star-forming systems, driving them out of equilibrium. After including Gaia DR3 proper motion errors, we find proper motions can be as useful as line-of-sight velocities for nearby systems at < ∼60 kpc. By extrapolating the actual density profiles and the dynamical constraints down to scales below the resolution, we find the mass within 150 pc can be an unbiasedly constrained ensemble, with a scatter of ∼0.255 dex. We show that the contraction of member stars in nearby systems is detectable based on Gaia DR3 proper motion errors

CD180 Ligation Inhibits TLR7- and TLR9-Mediated Activation of Macrophages and Dendritic Cells Through the Lyn-SHP-1/2 Axis in Murine Lupus

Activation of TLR7 and TLR9 by endogenous RNA- or DNA-containing ligands, respectively, can lead to hyper-activation of immune cells, including macrophages and DCs, subsequently contributes to the pathogenesis of SLE. CD180, a TLR-like protein, is specifically involved in the development and activation of immune cells. Our previous study and others have reported that CD180-negative B cells are dramatically increased in SLE patients and responsible for the production of auto-antibodies. However, the mode of CD180 expression on macrophages and DCs in SLE remains unclear and the role of CD180 on regulating TLR7- and TLR9-mediated activation of macrophages and DCs are largely unknown. In the present study, we found that the percentages of CD180-negative macrophages and DCs were both increased in SLE patients and lupus-prone MRL/lpr mice compared with healthy donors and wild-type mice, respectively. Notably, ligation of CD180 significantly inhibited the activation of TLR7 and TLR9 signaling pathways in macrophages and DCs through the Lyn-SHP-1/2 axis. What's more, injection of anti-CD180 Ab could markedly ameliorate the lupus-symptoms of imiquimod-treated mice and lupus-prone MRL/lpr mice through inhibiting the activation of macrophages and DCs. Collectively, our results highlight a critical role of CD180 in regulating TLR7- and TLR9-mediated activation of macrophages and DCs, hinting that CD180 can be regarded as a potential therapeutic target for SLE treatment

5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation

While it is well established that treatment of cancer patients with 5-Fluorouracil (5-FU) can result in immune suppression, the exact function of 5-FU in the modulation of immune cells has not been fully established. We found that low dose 5-FU selectively suppresses TH17 and TH1 cell differentiation without apparent effect on Treg, TH2, and significantly suppresses thymidylate synthase (TS) expression in TH17 and TH1 cells but has a lesser effect in tumor cells and macrophages. Interestingly, the basal expression of TS varies significantly between T helper phenotypes and knockdown of TS significantly impairs TH17 and TH1 cell differentiation without affecting the differentiation of either Treg or TH2 cells. Finally, low dose 5-FU is effective in ameliorating colitis development by suppressing TH17 and TH1 cell development in a T cell transfer colitis model. Taken together, the results highlight the importance of the anti-inflammatory functions of low dose 5-FU by selectively suppressing TH17 and TH1 immune responses