The fisheries of Zanzibar: potential for new investments

Zanzibar, one of the poorest areas of sub-Saharan Africa, has a good potential for foreign investment in offshore (EEZ) marine capture fisheries, in aquaculture and in fi sheries infrastructure. Zanzibar’s fisheries resources could be better managed in an effort to alleviate the poverty of its rural population and to provide food security. At present, Zanzibar’s fisheries are artisanal and its total annual production of fish of just over 20000 t, caught in inshore waters, is consumed locally. The government of Zanzibar has liberalized its policies to make Zanzibar a good environment for foreign investment

AN EFFICIENT HEURISTIC TO BALANCE TRADE-OFFS BETWEEN UTILIZATION AND PATIENT FLOWTIME IN OPERATING ROOM MANAGEMENT

Balancing trade-offs between production cost and holding cost is critical for production and operations management. Utilization of an operating room affects production cost, which relates to makespan, and patient flowtime affects holding cost. There are trade-offs between two objectives, to minimize makespan and to minimize flowtime. However, most existing constructive heuristics focus only on single-objective optimization. In the current literature, NEH is the best constructive heuristic to minimize makespan, and LR heuristic is the best to minimize flowtime. In this thesis, we propose a current and future deviation (CFD) heuristic to balance trade-offs between makespan and flowtime minimizations. Based on 5400 randomly generated instances and 120 instances in Taillard’s benchmarks, our CFD heuristic outperforms NEH and LR heuristics on trade-off balancing, and achieves the most stable performances from the perspective of statistical process control

Dimeric 2G12 as a Potent Protection against HIV-1

We previously showed that broadly neutralizing anti-HIV-1 antibody 2G12 (human IgG1) naturally forms dimers that are more potent than monomeric 2G12 in in vitro neutralization of various strains of HIV-1. In this study, we have investigated the protective effects of monomeric versus dimeric 2G12 against HIV-1 infection in vivo using a humanized mouse model. Our results showed that passively transferred, purified 2G12 dimer is more potent than 2G12 monomer at preventing CD4 T cell loss and suppressing the increase of viral load following HIV-1 infection of humanized mice. Using humanized mice bearing IgG “backpack” tumors that provided 2G12 antibodies continuously, we found that a sustained dimer concentration of 5–25 µg/ml during the course of infection provides effective protection against HIV-1. Importantly, 2G12 dimer at this concentration does not favor mutations of the HIV-1 envelope that would cause the virus to completely escape 2G12 neutralization. We have therefore identified dimeric 2G12 as a potent prophylactic reagent against HIV-1 in vivo, which could be used as part of an antibody cocktail to prevent HIV-1 infection

The problem of the underachievement of the English working class at school: Special reference to the "community school"

[Δε διατίθεται περίληψη / no abstract available]The argument around the problem of the working classunderachievement at school has been moving away from the conceptof cultural or linguistic deprivation of the working class student,which prevailed as a main explanation of the problem in the '60’s. Asa cause of the above issue there is, in the 70’s, a considerable emphasisupon the internal organization and the education content ofthe school which transmits the middle-class values of the society andrepresents the middle-class culture as «total culture».The «community school» in England within the radical approachhas developed in an effort to search, mainly in socio-economicallydeprived areas, for alternative rather than traditional ways of affectingthe school performance of the underachieving student. Thisoutlook may involve radical change not only in the role of the schoolwithin its community, but in the selection and organization ofknowledge at school as well

D. H. Lawrence- Bertrand Russell: Their short "hectic' friendship and commitment to social reform

[Δε διατίθεται περίληψη / no abstract available][Δε διατίθεται περίληψη / no abstract available

D. H. Lawrence- Bertrand Russell: Their short "hectic' friendship and commitment to social reform

[Δε διατίθεται περίληψη / no abstract available][Δε διατίθεται περίληψη / no abstract available

Long-term culture captures injury-repair cycles of colonic stem cells

The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key epithelial changes that occur in vivo during damage and repair. Here, we identify a Hop

An Efficient Constructive Heuristic to Balance Trade-Offs Between Makespan and Flowtime in Permutation Flow Shop Scheduling

Balancing trade-offs between production cost and holding cost is critical for production and operations management. Utilization of a production line affects production cost, which relates to makespan, and work-in-process (WIP) inventories in a production line affect holding cost, which relate to flowtime. There are trade-offs between two objectives, to minimize makespan and to minimize flowtime. Without addressing trade-off balancing issues in flow shop scheduling, WIP inventories are still high in manufacturing, generating unnecessary holding cost. However, utilization is coupled with WIP inventories. Low WIP inventory levels might lower utilization and generate high production cost. Most existing constructive heuristics focus only on single-objective optimization. In the current literature, the NEH heuristic proposed by Nawaz, Enscore, and Ham (1983) is the best constructive heuristic to minimize makespan, and the LR heuristic proposed by Liu and Reeves (2001) is the best to minimize flowtime. In this paper, we propose a current and future deviation (CFD) heuristic to balance trade-offs between makespan and flowtime minimizations. Based on 5400 randomly generated instances, 120 instances in Taillard’s benchmarks, and one-year historical records of operating room scheduling from University of Kentucky HealthCare (UKHC), our CFD heuristic outperforms the NEH and LR heuristics on trade-off balancing, and achieves the most stable performances from the perspective of statistical process control (SPC)