17 research outputs found
Functional activity of the oral endothelium in persons, with chronic periodontitis during treatment with plasmolifting
Chronic periodontitis as an osteoimmune disease of the oral cavity is accompanied by a change in the functional activity of endotheliocytes. Moreover, abnormal vascularization exacerbates periodontal inflammation, as it promotes the transmigration of a larger number of immunocompetent cells, the influx of inflammatory mediators and cytokines.The aim of our work was to study the functional activity of the endothelium of the vessels of the oral cavity in persons suffering from chronic periodontitis in the treatment of plasmolifting.Materials and methods. Under observation were 30 patients diagnosed with chronic generalized periodontitis of moderate severity at the age of 35 (32.50; 40.00) years, with no severe somatic pathology (main group). The comparison group included 20 people aged 38 (34.00; 45.00) years with no inflammatory diseases in the oral cavity. All patients underwent local anti-inflammatory therapy and sanitation of periodontal pockets, correction of occlusal contacts, curettage, plasma lifting. Oral fluid concentration of soluble adhesion molecules ICAM-1 and VCAM-1, endothelin-1, qualitative and quantitative composition of microflora were determined.Results. After the treatment with plasmolifting, a noticeable relief of the activity of the inflammatory process was observed. In patients with chronic periodontitis, Porphyromonas gingivalis was found in 100 % of cases in a titer of 5.73 (4.9; 6.7) lg (gEq/sample), in 62.5 % β Prevotella intermedia in a titer of 4.5 (3.0; 5.5) lg (gEq/sample). Against the background of therapy, decrease of the occurrence of the microorganism and of the number of microorganisms was observed. The concentration of the soluble form of VCAM-1 in the oral fluid of patients with chronic periodontitis exceeded the values of the control group by 38.3 times (p = 0.000001), and ICAM-1 β by 18.1 times (p = 0.00001). Against the background of plasmolifting therapy, the level of the studied substances decreased, but exceeded the control values by 25.2 and 6.4 times, respectively. The content of endothelin in the oral fluid in patients with periodontitis exceeded the values of healthy individuals by 40.7 % (p = 0.003), during therapy its values decreased, but did not reach the level of healthy volunteers (p = 0.04)
Time course of autoantibodies to collagen type I and III in blood serum and skin exudate in atopic dermatitis
In accordance with Clinical Guidelines of the Russian Society of Dermatovenerologists and Cosmetologists, atopic dermatitis is a chronic allergic genetically determined dermatosis of a multifactorial nature. There are, however, some aspects that challenge the allergic nature of dermatosis. For example, according to literature data, not all the patients have increased synthesis of immunoglobulin E, some of them are torpid to antihistamine treatment, and, when examining the skin of some patients with atopic dermatitis, an absolute polymorphism of rashes is revealed, thus being not typical to the reagin-type allergic reactions. According to modern data, autoimmune theory is assumed for the mechanisms of atopic dermatitis. However, objective proofs of this theory have not been presented, thus drawing our attention to the studies of this issue. The aim of this study was to identify autoimmune pathogenetic mechanisms of atopic dermatitis. The study included 40 adolescents and 40 adult patients with limited and extended forms of atopic dermatitis. The patients were evaluated during the period of exacerbation and remission of the disease. Blood and skin exudates samples were taken from all the patients. The control group consisted of 30 practically healthy volunteers in whom skin exudate was obtained by the βskin windowβ technique as proposed by Klimov V.V. et al. βA method for assessing minimal inflammatory activity of skin in atopic dermatitis in remissionβ. Concentrations of IgG autoantibodies to collagen types I and III were determined in blood serum and skin exudate samples applying ELISA techniques with ready-made panels AEA571Hu ELISA Kit for Anti-Collagen Type I Antibody (USA), AEA176Hu ELISA Kit for Anti-Collagen Type III Antibody (USA), according to the manufacturerβs protocols. For the first time, the contents of autoantibodies to skin collagen types I and III in the patients with atopic dermatitis we studied in parallel, i.e., at systemic level and in affected skin. If compared to the group of healthy volunteers, the concentration of autoantibodies to collagen types I and III was found to be increased in all the patients with atopic dermatitis, both during exacerbation and in remission of the disease. The maximal values of autoantibodies to collagen types I and III were recorded in blood serum upon development of clinical symptoms of dermatosis, along with low contents of these antibodies detectable in their skin exudates. Permanently high concentrations of autoantibodies to collagen types I and III in blood serum at exacerbation and remission of atopic dermatitis, and their low level in their skin exudate suggest emergence of circulating and precipitating immune complexes, thus allowing us to consider atopic dermatitis as an autoimmune process
ΠΠ·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΌΡΠΊΠΎΠ·Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΏΠΎΠ»ΠΎΡΡΠΈ ΡΡΠ° Ρ ΡΡΠΎΠ²Π½Π΅ΠΌ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΊΠ°ΡΠΈΠ΅ΡΠΎΠΌ
Aim. To determine the saliva level of immunoregulatory proteins in patients with rampant caries and 25-hydroxyvitamin D (25(OH)D) deficiency and evaluate the association of their concentration with 25(OH)D plasma level.Materials and methods. The study was performed in two groups. The experimental group included 15 patients aged 20β22 years with rampant caries and the 25(OH)D plasma level of < 20 ng / ml. The control group encompassed 15 healthy age-matched volunteers with the 25(OH)D plasma level of 20β100 ng / ml. The concentrations of B7.2 (CD86), free active TGF-Ξ²1, CTLA-4, PD-1, Tim-3, LAG-3, IGFBP-4, and ICAM-1 were assessed using flow cytometry. The levels of LL-37 and secretory immunoglobulin A (sIgA) were measured using ELISA. The Spearmanβs rank correlation coefficient was used to reveal a correlation between the indicated proteins and the 25(OH)D plasma level.Results. A decrease in B7.2 (CD86), PD-1, Tim-3, sIgA, and LL-37 and elevation of IGFBP-4 and ICAM-1 saliva levels were detected in patients with rampant caries and 25-hydroxyvitamin D deficiency. A positive Spearmanβs rank correlation coefficient was revealed between plasma 25(OH)D and saliva levels of free active TGF-Ξ²1, CTLA4, B7.2 (CD86), LL-37, and sIgA. A negative correlation was revealed between 25(OH)Dand ICAM-1.Conclusion. 25(OH)D deficiency in patients with rampant caries is associated with decreased levels of B7.2 (CD86), PD-1, Tim-3, sIgA, and LL-37 and elevated levels of IGFBP-4 and ICAM-1 in the saliva.Β Π¦Π΅Π»Ρ β ΠΎΡΠ΅Π½ΠΈΡΡ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
ΠΌΠΎΠ»Π΅ΠΊΡΠ» Π² ΡΠ»ΡΠ½Π΅ Ρ Π»ΠΈΡ Ρ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌ ΠΊΠ°ΡΠΈΠ΅ΡΠΎΠΌ ΠΈ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ 25(OH)D3 ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΈΡ
Π²Π΅Π»ΠΈΡΠΈΠ½ Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠ΅ΠΉ 25(OH)D3 Π² ΠΊΡΠΎΠ²ΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ Π΄Π²Π΅ Π³ΡΡΠΏΠΏΡ Π»ΠΈΡ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 20β22 Π»Π΅Ρ. Π ΠΎΠ΄Π½Ρ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ 15 ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ Ρ ΠΊΠ°ΡΠΈΠ΅ΡΠΎΠΌ ΠΈ ΡΡΠΎΠ²Π½Π΅ΠΌ 25(OH)D3 ΠΌΠ΅Π½Π΅Π΅ 20 Π½Π³/ΠΌΠ», Π² Π΄ΡΡΠ³ΡΡ (ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ) β 15 Π·Π΄ΠΎΡΠΎΠ²ΡΡ
ΡΠ΅Π»ΠΎΠ²Π΅ΠΊ Ρ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ 25(OH)D3 30β100 Π½Π³/ΠΌΠ». Π ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΡΡ
ΡΠΎΡΠΌ ΠΌΠΎΠ»Π΅ΠΊΡΠ» B7.2 (CD86), Free Active TGF-b1, CTLA-4, PD-1, Tim-3, LAG-3, IGFBP-4, ICAM-1 ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΡΠΎΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΡΠ»ΡΠΎΠΌΠ΅ΡΡΠΈΠΈ, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠ°ΡΠ΅Π»ΠΈΡΠΈΠ΄ΠΈΠ½Π° LL-37, ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½Π° A (IgA) ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°. ΠΠ΅ΠΆΠ΄Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΠΌΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΠ°ΡΡΡΠΈΡΠ°Π½ ΠΊΡΠΈΡΠ΅ΡΠΈΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ Π‘ΠΏΠΈΡΠΌΠ΅Π½Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ Π»ΠΈΡ Ρ ΠΊΠ°ΡΠΈΠ΅ΡΠΎΠΌ ΠΈ Π΄Π΅ΡΠΈΡΠΈΡΠΎΠΌ Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ Free Active TGF-b1, B7.2 (CD86), PD-1, Tim-3, sIgA, ΠΊΠ°ΡΠ΅Π»ΠΈΡΠΈΠ΄ΠΈΠ½Π° LL-37 ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ IGFBP-4 ΠΈ ICAM-1 Π² ΡΠ»ΡΠ½Π΅. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΏΡΡΠΌΡΡ
ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ²ΡΠ·Π΅ΠΉ ΠΌΠ΅ΠΆΠ΄Ρ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎΠΌ 25(OH)D3 Π² ΠΊΡΠΎΠ²ΠΈ, Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, ΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΡΠΌΠΈ Free Active TGF-b1, CTLA-4, Π7.2 (CD86), ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ IgA, ΠΏΠ΅ΠΏΡΠΈΠ΄Π° LL-37 β Ρ Π΄ΡΡΠ³ΠΎΠΉ. ΠΠ°ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°Π½Π° ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½Π°Ρ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ Π²Π΅Π»ΠΈΡΠΈΠ½Π°ΠΌΠΈ 25(OH)D3 ΠΈ ICAM-1.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ° ΡΠΎΠ½Π΅ Π΄Π΅ΡΠΈΡΠΈΡΠ° Π²ΠΈΡΠ°ΠΌΠΈΠ½Π° D ΠΏΡΠΈ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΌ ΠΊΠ°ΡΠΈΠ΅ΡΠ΅ Π² ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΡΡΡΡ Π½ΠΈΠ·ΠΊΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Free Active TGF-b1, B7.2 (CD86), PD-1, Tim-3, ΡΠ΅ΠΊΡΠ΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ IgA, ΠΊΠ°ΡΠ΅Π»ΠΈΡΠΈΠ΄ΠΈΠ½Π° LL-37 ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ΠΌ, Π½ΠΎ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½Ρ Π·Π½Π°ΡΠ΅Π½ΠΈΡ IGFBP-4 ΠΈ ICAM-1.
ΠΠ»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΈΠ½ΠΎΡΠΈΠ½ΡΡΠΎΠΏΠ°ΡΠΈΡ ΠΈ Π΅Π΅ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΠ΅Π΄ΠΈ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΠΎΡΡΠΎΡΠ½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ
The work is devoted to research of the ethnic characteristics of allergic rhinosinusopathy spread
among the population in Evenkia, as well as to clarification of its pathogenetic mechanisms. The author
studied the spread and structure of allergic rhinosinusopathy among Caucasians and Mongoloids in
Evenkia.
Using mathematical method of correlation adaptometry the author revealed the presence of significant
correlations between the detected characteristicsΠ‘ΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ
ΡΠΈΠ½ΠΎΡΠΈΠ½ΡΡΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΠ²Π΅Π½ΠΊΠΈΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΠΎΡΠ½Π΅Π½ΠΈΡ Π΅Π΅ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ².
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ ΠΈ ΡΡΡΡΠΊΡΡΡΠ° Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΠ½ΠΎΡΠΈΠ½ΡΡΠΎΠΏΠ°ΡΠΈΠΈ ΡΡΠ΅Π΄ΠΈ
Π΅Π²ΡΠΎΠΏΠ΅ΠΎΠΈΠ΄ΠΎΠ² ΠΈ ΠΌΠΎΠ½Π³ΠΎΠ»ΠΎΠΈΠ΄ΠΎΠ² ΠΠ²Π΅Π½ΠΊΠΈΠΈ. Π‘ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ
Π°Π΄Π°ΠΏΡΠΎΠΌΠ΅ΡΡΠΈΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΠΌΠΈ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌ
ΠΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½Π΅ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π·Π°Π½Π΅Π΄Π±Π°Π½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡ ΡΠΈΡΠΎΠΏΠΎΠ΄ΡΠ±Π½ΠΎΡ Π·Π°Π»ΠΎΠ·ΠΈ
An analysis of the results of supervising 108 patients with primary unresectable locally invasive thyroid cancer, undergoing a course of treatment at the Donetsk Oncological Antitumoral Center (DOAC) from 2000 to 2011, served as a material for a research. The treatment in all the patients started by performing x-ray therapy by small fractions. A tumor regression was noted in all the patients of the group under study, consisting of 53 patients, enabling to perform a radical surgical interference, as a rule, in the range of extensive thyroidectomies with different types of lymph dissections. No essential changes were observed in 39 patients following the treatment performed (a stabilization process). Unfortunately, a disease progression was noted in 16 patients. Afterwards all the operated patients underwent radio iodine therapy. A five-year survival rate in patients undergoing a preoperative course of x-ray therapy, made up 63 %. All the patients who did not undergo an operation following a course of x-ray therapy died during a 2-year period. The introduction into clinical practice of a course of x-ray treatment in case of primary nonresectable thyroid cancer enables to perform surgical interference in a radical range, resulting in an improvement of the quality and duration of life, enabling to perform different variants of multimodality treatment of this particular cohort of patients afterwards.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠΌ Π΄Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΡΠ»ΡΠΆΠΈΠ» Π°Π½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ 108 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎ-Π½Π΅ΡΠ΅Π·Π΅ΠΊΡΠ°Π±Π΅Π»ΡΠ½ΡΠΌ ΠΌΠ΅ΡΡΠ½ΠΎΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠΌ ΡΠ°ΠΊΠΎΠΌ ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΠ»ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π² ΠΠΠΠ¦ Ρ 2000 ΠΏΠΎ 2011 Π³ΠΎΠ΄. Π£ Π²ΡΠ΅Ρ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π½Π°ΡΠΈΠ½Π°Π»ΠΈ Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π’ΠΠ’ ΠΌΠ΅Π»ΠΊΠΈΠΌΠΈ ΡΡΠ°ΠΊΡΠΈΡΠΌΠΈ. Π ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Ρ 53 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΎΡΠΌΠ΅ΡΠ΅Π½Π° ΡΠ΅Π³ΡΠ΅ΡΡΠΈΡ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ²ΡΠ°Ρ Π²ΡΠΏΠΎΠ»Π½ΠΈΡΡ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²ΠΎ, ΠΊΠ°ΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, Π² ΠΎΠ±ΡΠ΅ΠΌΠ΅ ΡΠ°ΡΡΠΈΡΠ΅Π½Π½ΡΡ
ΡΠΈΡΠ΅ΠΎΠΈΠ΄ΡΠΊΡΠΎΠΌΠΈΠΉ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π²ΠΈΠ΄Π°ΠΌΠΈ ΡΠ΅ΠΉΠ½ΡΡ
Π»ΠΈΠΌΡΠΎΠ΄ΠΈΡΡΠ΅ΠΊΡΠΈΠΉ. Π£ 39 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π½Π΅ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ (ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·Π°ΡΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠ°). Π ΡΠΎΠΆΠ°Π»Π΅Π½ΠΈΡ, Ρ 16 Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΎΡΠΌΠ΅ΡΠ΅Π½ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΠΎΠ»Π΅Π·Π½ΠΈ. ΠΡΠ΅ ΠΏΡΠΎΠΎΠΏΠ΅ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π±ΠΎΠ»ΡΠ½ΡΠ΅ Π² ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠ΅ΠΌ ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ ΡΠ°Π΄ΠΈΠΎΠΉΠΎΠ΄ΡΠ΅ΡΠ°ΠΏΠΈΡ. ΠΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΠΏΡΡΠΈΠ»Π΅ΡΠ½Π΅ΠΉ Π²ΡΠΆΠΈΠ²Π°Π΅ΠΌΠΎΡΡΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΊΡΡΡ Π’ΠΠ’, ΡΠΎΡΡΠ°Π²ΠΈΠ» 63 %. ΠΡΠ΅ Π±ΠΎΠ»ΡΠ½ΡΠ΅, ΠΊΠΎΡΠΎΡΡΠΌ Π½Π΅ ΡΠ΄Π°Π»ΠΎΡΡ Π²ΡΠΏΠΎΠ»Π½ΠΈΡΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΡ ΠΏΠΎΡΠ»Π΅ ΠΊΡΡΡΠ° Π’ΠΠ’, ΡΠΌΠ΅ΡΠ»ΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π΄Π²ΡΡ
Π»Π΅Ρ. ΠΠ½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ Π² ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΊΡΡΡΠ° Π’ΠΠ’ ΠΏΡΠΈ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎ-Π½Π΅ΡΠ΅Π·Π΅ΠΊΡΠ°Π±Π΅Π»ΡΠ½ΠΎΠΌ ΡΠ°ΠΊΠ΅ ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ Π² Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΠ°ΡΡΠΈ ΡΠ»ΡΡΠ°Π΅Π² Π΄Π°Π΅Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Π² ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΌ ΠΎΠ±ΡΠ΅ΠΌΠ΅, ΡΡΠΎ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΆΠΈΠ·Π½ΠΈ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ Π² Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΌ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
.ΠΠ°ΡΠ΅ΡΡΠ°Π»ΠΎΠΌ Π΄Π»Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΠΏΠΎΡΠ»ΡΠΆΠΈΠ² Π°Π½Π°Π»ΡΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡΠ² ΡΠΏΠΎΡΡΠ΅ΡΠ΅ΠΆΠ΅Π½Π½Ρ 108 Ρ
Π²ΠΎΡΠΈΡ
Π½Π° ΠΏΠ΅ΡΠ²ΠΈΠ½Π½ΠΎ-Π½Π΅ΡΠ΅Π·Π΅ΠΊΡΠ°Π±Π΅Π»ΡΠ½ΠΈΠΉ ΠΌΡΡΡΠ΅Π²ΠΎΠΏΠΎΡΠΈΡΠ΅Π½ΠΈΠΉ ΡΠ°ΠΊ ΡΠΈΡΠΎΠΏΠΎΠ΄ΡΠ±Π½ΠΎΡ Π·Π°Π»ΠΎΠ·ΠΈ, ΡΠΊΡ ΠΏΡΠΎΡ
ΠΎΠ΄ΠΈΠ»ΠΈ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π² ΠΠΠΠ¦ ΡΠ· 2000 ΠΏΠΎ 2011 ΡΡΠΊ. Π£ Π²ΡΡΡ
ΠΎΡΡΠ± Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π½ΠΎΡ Π³ΡΡΠΏΠΈ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ ΠΏΠΎΡΠΈΠ½Π°Π»ΠΈ Π· ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ Π’ΠΠ’ Π΄ΡΡΠ±Π½ΠΈΠΌΠΈ ΡΡΠ°ΠΊΡΡΡΠΌΠΈ. Π£ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π½ΡΠΉ Π³ΡΡΠΏΡ Π² 53 ΠΏΠ°ΡΡΡΠ½ΡΡΠ² Π²ΡΠ΄Π·Π½Π°ΡΠ΅Π½Π° ΡΠ΅Π³ΡΠ΅ΡΡΡ ΠΏΡΡ
Π»ΠΈΠ½ΠΈ, ΡΠΎ Π΄ΠΎΠ·Π²ΠΎΠ»ΠΈΠ»Π° Π²ΠΈΠΊΠΎΠ½Π°ΡΠΈ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½Π΅ Π²ΡΡΡΡΠ°Π½Π½Ρ, ΡΠΊ ΠΏΡΠ°Π²ΠΈΠ»ΠΎ, Π² ΠΎΠ±ΡΡΠ·Ρ ΡΠΎΠ·ΡΠΈΡΠ΅Π½ΠΎΡ ΡΠΈΡΠ΅ΠΎΡΠ΄Π΅ΠΊΡΠΎΠΌΡΡ Π· ΡΡΠ·Π½ΠΈΠΌΠΈ Π²ΠΈΠ΄Π°ΠΌΠΈ ΡΠΈΠΉΠ½ΠΈΡ
Π»ΡΠΌΡΠΎΠ΄ΠΈΡΠ΅ΠΊΡΡΠΉ. Π£ 39 ΠΏΠ°ΡΡΡΠ½ΡΡΠ² ΡΡΡΠΎΡΠ½ΠΈΡ
Π·ΠΌΡΠ½ ΠΏΡΡΠ»Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎΠ³ΠΎ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Π½Π΅ ΡΠΏΠΎΡΡΠ΅ΡΡΠ³Π°Π»ΠΎΡΡ (ΡΡΠ°Π±ΡΠ»ΡΠ·Π°ΡΡΡ ΠΏΡΠΎΡΠ΅ΡΡ). ΠΠ° ΠΆΠ°Π»Ρ, Ρ 16 ΠΏΠ°ΡΡΡΠ½ΡΡΠ² Π²ΡΠ΄Π·Π½Π°ΡΠ΅Π½ΠΎ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠ²Π°Π½Π½Ρ Ρ
Π²ΠΎΡΠΎΠ±ΠΈ. ΠΡΡ ΠΏΡΠΎΠΎΠΏΠ΅ΡΠΎΠ²Π°Π½Ρ ΠΎΡΠΎΠ±ΠΈ Π² ΠΏΠΎΠ΄Π°Π»ΡΡΠΎΠΌΡ ΠΎΡΡΠΈΠΌΡΠ²Π°Π»ΠΈ ΡΠ°Π΄ΡΠΎΠΉΠΎΠ΄ΡΠ΅ΡΠ°ΠΏΡΡ. ΠΠΎΠΊΠ°Π·Π½ΠΈΠΊ ΠΏ'ΡΡΠΈΡΡΡΠ½ΠΎΡ Π²ΠΈΠΆΠΈΠ²Π°Π½ΠΎΡΡΡ Π² ΠΎΡΡΠ±, ΡΠΊΡ ΠΎΡΡΠΈΠΌΡΠ²Π°Π»ΠΈ ΠΏΠ΅ΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΡΠΉΠ½ΠΈΠΉ ΠΊΡΡΡ Π’ΠΠ’, ΡΡΠ°Π½ΠΎΠ²ΠΈΠ² 63 %. ΠΡΡ Ρ
Π²ΠΎΡΡ, ΡΠΊΠΈΠΌ Π½Π΅ Π²Π΄Π°Π»ΠΎΡΡ Π²ΠΈΠΊΠΎΠ½Π°ΡΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΡΡ ΠΏΡΡΠ»Ρ ΠΊΡΡΡΡ Π’ΠΠ’, ΠΏΠΎΠΌΠ΅ΡΠ»ΠΈ ΠΏΡΠΎΡΡΠ³ΠΎΠΌ Π΄Π²ΠΎΡ
ΡΠΎΠΊΡΠ². ΠΠΏΡΠΎΠ²Π°Π΄ΠΆΠ΅Π½Π½Ρ Π² ΠΊΠ»ΡΠ½ΡΡΠ½Ρ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ ΠΏΠ΅ΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΡΠΉΠ½ΠΎΠ³ΠΎ ΠΊΡΡΡΡ Π’ΠΠ’ ΠΏΡΠΈ ΠΏΠ΅ΡΠ²ΠΈΠ½Π½ΠΎ-Π½Π΅ΡΠ΅Π·Π΅ΠΊΡΠ°Π±Π΅Π»ΡΠ½ΠΎΠΌΡ ΡΠ°ΠΊΡ ΡΠΈΡΠΎΠΏΠΎΠ΄ΡΠ±Π½ΠΎΡ Π·Π°Π»ΠΎΠ·ΠΈ Π² Π±ΡΠ»ΡΡΡΠΉ ΡΠ°ΡΡΠΈΠ½Ρ Π²ΠΈΠΏΠ°Π΄ΠΊΡΠ² Π΄Π°Ρ ΠΌΠΎΠΆΠ»ΠΈΠ²ΡΡΡΡ Π²ΠΈΠΊΠΎΠ½Π°Π½Π½Ρ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΡΡΡΡΠ°Π½Π½Ρ Π² ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΌΡ ΠΎΠ±ΡΡΠ·Ρ, ΡΠΎ ΠΏΡΠΈΠ·Π²ΠΎΠ΄ΠΈΡΡ Π΄ΠΎ ΠΏΠΎΠ»ΡΠΏΡΠ΅Π½Π½Ρ ΡΠΊΠΎΡΡΡ Ρ ΡΡΠΈΠ²Π°Π»ΠΎΡΡΡ ΠΆΠΈΡΡΡ, Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΠΈ Π² ΠΏΠΎΠ΄Π°Π»ΡΡΠΎΠΌΡ ΡΡΠ·Π½Ρ Π²Π°ΡΡΠ°Π½ΡΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π»ΡΠΊΡΠ²Π°Π½Π½Ρ Ρ
Π²ΠΎΡΠΈΡ
Π΄Π°Π½ΠΎΡ ΠΊΠ°ΡΠ΅Π³ΠΎΡΡΡ
Temperature-Responsive Linear Polyelectrolytes and Hydrogels Based on [2-(Methacryloyloxy)ethyl] trimethylammonium chloride and N-isopropylacrylamide and Their Complex Formation with Potassium Hexacyanoferrates (II, III)
First study of lithium boron composite as plasma facing material
Lithium-Boron Composite Material (LBCM) is presented as a plasma-facing material with a lot of promise from the perspective of liquid metal first wall. LBCM consists ofΒ βΌΒ 20 w.% boron andΒ βΌΒ 80 w.% lithium, arranged in the form of a Li5B4 matrix filled with metal lithium, similar to capillary porous systems (CPS) already used as plasma-facing elements. The characteristic matrix cell size is approximately 5Β Β΅m. LBCM was subjected to electron flux and helium plasma in a linear PR-2 device. LBCM maintained physical integrity up to TΒ >Β 900Β Β°C. Boron didnβt evaporate from LBCM under electron irradiation, but was sputtered during helium bombardment. CPS-like properties, wherein Li from the whole of the LBCM sample was transported to the area of the highest thermal load were observed
ΠΠ»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ ΡΠΈΠ½ΠΎΡΠΈΠ½ΡΡΠΎΠΏΠ°ΡΠΈΡ ΠΈ Π΅Π΅ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΠ΅Π΄ΠΈ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΠΎΡΡΠΎΡΠ½ΠΎΠΉ Π‘ΠΈΠ±ΠΈΡΠΈ
The work is devoted to research of the ethnic characteristics of allergic rhinosinusopathy spread
among the population in Evenkia, as well as to clarification of its pathogenetic mechanisms. The author
studied the spread and structure of allergic rhinosinusopathy among Caucasians and Mongoloids in
Evenkia.
Using mathematical method of correlation adaptometry the author revealed the presence of significant
correlations between the detected characteristicsΠ‘ΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ
ΡΠΈΠ½ΠΎΡΠΈΠ½ΡΡΠΎΠΏΠ°ΡΠΈΠ΅ΠΉ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΠ²Π΅Π½ΠΊΠΈΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΡΠΎΡΠ½Π΅Π½ΠΈΡ Π΅Π΅ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ².
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΡΡΡ ΠΈ ΡΡΡΡΠΊΡΡΡΠ° Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΠ½ΠΎΡΠΈΠ½ΡΡΠΎΠΏΠ°ΡΠΈΠΈ ΡΡΠ΅Π΄ΠΈ
Π΅Π²ΡΠΎΠΏΠ΅ΠΎΠΈΠ΄ΠΎΠ² ΠΈ ΠΌΠΎΠ½Π³ΠΎΠ»ΠΎΠΈΠ΄ΠΎΠ² ΠΠ²Π΅Π½ΠΊΠΈΠΈ. Π‘ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ
Π°Π΄Π°ΠΏΡΠΎΠΌΠ΅ΡΡΠΈΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π½Π°Π»ΠΈΡΠΈΠ΅ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΠΌΠΈ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌ