The Grizzly, October 12, 1984

Students and Administrators Disagree on Effectiveness of Existing Alcohol Policies • Former Economics Chairman Now ACE Fellow • Twisted Sister and the State of Modern Youth Dissidence • News of Yesteryear: War Brings Feminine Touch to Freeland Hall • UC Welcomes Three Foreign Students • Gridders Handle Hopkins • Off-Campus Entertainment: Pulsations! • Shorts: Ferguson Concert; Thurber Carnival; Trivia-thon Scheduled • New Faculty: Math Welcomes Shaw • Some Keystone Factshttps://digitalcommons.ursinus.edu/grizzlynews/1124/thumbnail.jp

The Grizzly, September 28, 1984

Limerick: Nuclear Power Comes to Montgomery County • Communication Arts\u27 Newest Member • News of Yesteryear: Is There a Ghost in UC\u27s Haunted Hall? • Shorts: PA German Studies; Political Ad Forum; Appointment • Soccer Rebounds From Loss to Drexel • X-Country Competes in Invitational • Hockey Player Named to US Squad • Pro Football Wrap-Up • Grizzlies Lose to W. Marylandhttps://digitalcommons.ursinus.edu/grizzlynews/1122/thumbnail.jp

The Grizzly, April 6, 1984

Loyalty Fund Phon-a-thon, Successful • Parsons Re-elected VP of Historical Society • Nagy\u27s Stellar Lecture • McQuaid Presents Views on Candidates • Letters to the Editor: Fraternities Help to Combat Apathy; Bubble World ; UC Social Life Needs Help; Pledging Not Destructive; Pledging Enhances Development; To Ban Pledging not a Positive Aspect; In Memory of Zeta Chi; Pledging to Expand Socially • Patrol Pattern Changed, Woman is Assaulted • The Limerick Syndrome: What Would UC do? • Mardi Gras Ball Declared Success • Changing Picture of Health in \u2780\u27s • Ride for Your Life! • Two Views on the Bussing Situation • Women\u27s Tennis Splits in Opening Matches • Softball Undefeated at 6-0 • Tennis Team Nets Two Victories • Denning Captures Fencing Title • Strizke, Rosenberg Qualify for Gymnastics Championship • Men\u27s Track Kicks off \u2784 Season • Men\u27s Lacrosse Thumps Bloomsburg • Hot Hitting Leads Bears Batsmen to Victories • Baseball Team Raises Record to 6-3 • Women\u27s Track Promisinghttps://digitalcommons.ursinus.edu/grizzlynews/1116/thumbnail.jp

The Grizzly, March 2, 1984

Reagan Proposes to Cut Student Aid: 62% Ursinus Students Could Feel Bite • Tray Offenders Discussed • Students Elect New USGA Officers • Writing Seminar Features Alumni • Presidents Corner: Frats Move in Desirable Direction • Letters to the Editor: USGA Concerned With Student Apathy; Get in Gear • Board Elects Two New Members, Appoints Seven • Women\u27s Club Plans Events • WRUC Gets Technician • The Lantern Seeks Contributions • Cogger Heads State Study • Fall Registration Looms on Horizon • Learn While You Work • Sports Profile: Mo Gorman Excels • Basketball Team Wraps Up 83-84 Season • Bears Make Tracks • Grapplers Shine At MACs: Doyle Crowned 150lb Champ; Racich Named Coach of the Year • Doyle and Paolone Successful in MAC Competition • Satisfied with Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1114/thumbnail.jp

The Grizzly, March 2, 1984

Reagan Proposes to Cut Student Aid: 62% Ursinus Students Could Feel Bite • Tray Offenders Discussed • Students Elect New USGA Officers • Writing Seminar Features Alumni • Presidents Corner: Frats Move in Desirable Direction • Letters to the Editor: USGA Concerned With Student Apathy; Get in Gear • Board Elects Two New Members, Appoints Seven • Women\u27s Club Plans Events • WRUC Gets Technician • The Lantern Seeks Contributions • Cogger Heads State Study • Fall Registration Looms on Horizon • Learn While You Work • Sports Profile: Mo Gorman Excels • Basketball Team Wraps Up 83-84 Season • Bears Make Tracks • Grapplers Shine At MACs: Doyle Crowned 150lb Champ; Racich Named Coach of the Year • Doyle and Paolone Successful in MAC Competition • Satisfied with Nationalshttps://digitalcommons.ursinus.edu/grizzlynews/1114/thumbnail.jp

The Grizzly, March 23, 1984

Assault Attempt on Ursinus Female • Speaker Gives Business Pointers • Forced Bussing in Wismer • New Course for Comm Arts Minor • Letters to the Editor • 1984 Fraternity Pledging Ends • New Fine Arts Course Planned for Fall • In my Opinion: Pledging Should be Banned • Meistersingers Give Return Performance • UC Sponsors Science Competition • Dr. Clouser Delivers Goethe Lecture • Lift-A-Thon Raises Funds for New Equipment • Bear Blades Remain Undefeated • Housing Changes Imminent • Orchestra Presents Bach Festival • Aquabears Conclude Best Season Ever • Batsmen Victorious in Opener • Men\u27s Lacrosse Optimistic • Track Team Looking Solidhttps://digitalcommons.ursinus.edu/grizzlynews/1115/thumbnail.jp

The Grizzly, October 5, 1984

Political Ad Forum Set • Blood Drive Exceeds Quota • Education Dept Lauded For Teacher Preparation Efforts • News of Yesteryear: Fleet Men Relate Overseas Experiences; Students Ask $561 in War Fund Drive • Letters: Student Opposes Conformity; Wet Commuter • Limerick Pt 2: The Evacuation Plan • Senior Ec/Ba Accounting Student Honored • Gridders Drop Third Straight • Tannenbaum Fills New Sports Information Post • Regular Baseball Season Ends • New Faculty Profiles: Zemel Joins Economics Department • Shorts: Pottery Exhibit; Career Workshop; Fellowships; Red and Gold Days; Speech Exam; Friends\u27 Book Salehttps://digitalcommons.ursinus.edu/grizzlynews/1123/thumbnail.jp

The Effector Domain of MARCKS Is a Nuclear Localization Signal that Regulates Cellular PIP2 Levels and Nuclear PIP2 Localization

Translocation to the nucleus of diacylglycerol kinase (DGK)– ζ is dependent on a sequence homologous to the effector domain of Myristoylated Alanine Rich C-Kinase Substrate (MARCKS). These data would suggest that MARCKS could also localize to the nucleus. A single report demonstrated immunofluorescence staining of MARCKS in the nucleus; however, further experimental evidence confirming the specific domain responsible for this localization has not been reported. Here, we report that MARCKS is present in the nucleus in GBM cell lines. We then over-expressed wild-type MARCKS (WT) and MARCKS with the effector domain deleted (ΔED), both tagged with V5-epitope in a GBM cell line with low endogenous MARCKS expression (U87). We found that MARCKS-WT localized to the nucleus, while the MARCKS construct without the effector domain remained in the cytoplasm. We also found that over-expression of MARCKS-WT resulted in a significant increase in total cellular phosphatidyl-inositol (4,5) bisphosphate (PIP2) levels, consistent with prior evidence that MARCKS can regulate PIP2 levels. We also found increased staining for PIP2 in the nucleus with MARCKS-WT over-expression compared to MARCKS ΔED by immunofluorescence. Interestingly, we observed MARCKS and PIP2 co-localization in the nucleus. Lastly, we found changes in gene expression when MARCKS was not present in the nucleus (MARCKS ΔED). These data indicate that the MARCKS effector domain can function as a nuclear localization signal and that this sequence is critical for the ability of MARCKS to regulate PIP2 levels, nuclear localization, and gene expression. These data suggests a novel role for MARCKS in regulating nuclear functions such as gene expression

The Grizzly, September 14, 1984

Record Number Enter Ursinus • Town Hears College Plans • An Athlete\u27s Battle With Alcohol • News of Yesteryear • Ursinus Enters New Era of Communications • Cobbs Shows Enthusiasm for New Position • New Dean Coaches R.A.\u27s • English Moves Into New Offices • Smooth Sailing for Hockey....on a Bumpy Field • UC Soccer Wins Home Opener • Gridders Look to Be Winners • Cross Country Kicks Off \u2784 Season • Discover Philadelphia • McQuellan Leaves • Calendarhttps://digitalcommons.ursinus.edu/grizzlynews/1120/thumbnail.jp