Fundamentos y propuestas para impulsar un Programa Institucional que potencie el Impacto Social del Conocimiento en la Universidad Tecnológica Nacional

El presente artículo refleja los fundamentos y propuestas para impulsar un Programa Institucional que potencie el impacto social del conocimiento en la Universidad Tecnológica Nacional diseñado a fin de cumplir con los requerimientos del plan de mejora en el que se ha comprometido la universidad. El artículo está organizado en cuatro apartados. En el primero se analiza la emergencia del conocimiento en la sociedad contemporánea, en el segundo se contextualiza y se da cuenta brevemente del origen de la Universidad Tecnológica Nacional y el marco y los aspectos centrales de su forma de concebir la producción de conocimiento. En una tercera sección se conceptualiza el impacto social y los abordajes teóricos que dan sustento a dicha categoría. Por último se establecen las propuestas para el fortalecimiento del impacto social en la Universidad Tecnológica Nacional.This paper discusses the concept of social impact of knowledge in the context of the management of higher education institutions. Taking into account the experience of the authors in the design of an institutional program for the National Technological University (UTN), the text addresses first the broader problem of knowledge production in contemporary society and then analyzes the concept of knowledge impact and how this notion can be incorporated in the management of universities. The article highlights the importance of learning from experiences om other countries, as well as the need to adapt them to the particularities of the local university system, and in particular to the challenges of a university focused in engineering. Finally, we describe our proposal for the creation of an institutional program that enhances the social impact of knowledge at UTN.Fil: Naidorf, Clara Judith. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Mazzola, Carlos Francisco. Universidad Nacional de San Luis; ArgentinaFil: Vasen, Federico. Universidad de Buenos Aires. Facultad de Ciencias Sociales; ArgentinaFil: Legnani, Walter. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; ArgentinaFil: Napoli, Fernando Pablo. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; Argentin

IMMU-01. TEM-GBM: AN OPEN-LABEL, PHASE I/IIA DOSE-ESCALATION STUDY EVALUATING THE SAFETY AND EFFICACY OF GENETICALLY MODIFIED TIE-2 EXPRESSING MONOCYTES TO DELIVER IFN-A WITHIN GLIOBLASTOMA TUMOR MICROENVIRONMENT

Abstract Temferon is a macrophage-based treatment relying on ex-vivo transduction of autologous HSPCs to express immune-payloads within the TME. Temferon targets the immune-modulatory molecule IFN-a, to a subset of tumor infiltrating macrophages known as Tie-2 expressing macrophages (TEMs) due to the Tie2 promoter and a post-transcriptional regulation layer represented by miRNA-126 target sequences. As of 31st May 2021, 15-patients received Temferon (D+0) with follow-up of 3 – 693 days. After conditioning neutrophil and platelet engraftment occurred at D+13 and D+13.5, respectively. Temferon-derived differentiated cells, as determined be the number of vector copy per genome, were found within 14 days post treatment and persisted albeit at lower levels up to 18-months. Very low concentrations of IFN-a in the plasma (8.7 pg/ml-D+30) and in the CSF (1.6 pg/ml-D+30) were detected, suggesting tight regulation of transgene expression. Five-deaths occurred at D+322, +340, +402, +478 and +646 due to PD, and one at D+60 due to complications following the conditioning regimen. Eight-patients had progressive disease (range: D-11 to +239) as expected for this tumor type. SAEs include GGT elevation (possibly related to Temferon) and infections, venous thromboembolism, brain abscess, hemiparesis, seizures, anemia and general physical condition deterioration, compatible with ASCT, concomitant medications and PD. Four-patients underwent 2ndsurgery. Recurrent tumors had gene-marked cells and increased expression of ISGs compared to first surgery, indicative of local IFNa release by TEMs. In one patient, a stable lesion had a higher proportion of T cells and TEMs within the myeloid infiltrate and an increased ISGs than in the progressing lesion, detected in the same patient. Tumor-associated clones expanded in the periphery. TME characterization by scRNA and TCR-sequencing is ongoing. To date, Temferon is well tolerated, with no DLTs identified. The results provide initial evidence of Temferon potential to activate the immune system of GBM patients, as predicted by preclinical studies

A new approach to identify kinematic peculiarities in human motion

A new matrix method developed by the authors, suitable for easy recognition of the kinematic characteristics of the human motion, is presented. The method is based on a coherent use of 4×4 matrices, and beside the usual homogeneous transformation matrix (here called position matrix) it uses three new matrices: the velocity (W), the acceleration (H) and the generalized speed ratio (L) matrices. A peculiar characteristic of these matrices is that they contain both the angular and linear terms(e.g.W includes both the linear and angular velocities of a body). Some features of this methodology are presented by means of practical examples concerning human motion analysis

New approach to identify kinematic peculiarities in human motion

A new matrix method developed by the authors, suitable for easy recognition of the kinematic characteristics of the human motion, is presented. The method is based on a coherent use of 4×4 matrices, and beside the usual homogeneous transformation matrix (here called position matrix) it uses three new matrices: the velocity (W), the acceleration (H) and the generalized speed ratio (L) matrices. A peculiar characteristic of these matrices is that they contain both the angular and linear terms(e.g.W includes both the linear and angular velocities of a body). Some features of this methodology are presented by means of practical examples concerning human motion analysis

A homogeneous matrix approach to 3D kinematics and dynamics - I. Theory

In this paper we present a new approach to the kinematic and dynamic analysis of rigid body systems in the form of a consistent method employing 4 x 4 matrices. This method can be considered a powerful extension of the well known method of homogeneous transformations proposed by Denavit and Hartenberg. New matrices are introduced to describe the velocity end the acceleration, the momentum, the inertia of bodies and the actions (forces and torques) applied to them. Each matrix contains both the angular and the linear terms and so the ''usual'' kinematic and dynamic relations can be rewritten, halving the number of equations. The resulting notation and expressions are simple, and very suitable for computer applications. A useful tensor interpretation of this method is also explained, and some connections of this notation with the screw theory and dual-quantities are quoted