Generating Recommendations From Multiple Data Sources: A Methodological Framework for System Design and Its Application

Recommender systems (RSs) are systems that produce individualized recommendations as output or drive the user in a personalized way to interesting or useful objects in a space of possible options. Recently, RSs emerged as an effective support for decision making. However, when people make decisions, they usually take into account different and often conicting information such as preferences, long-term goals, context, and their current condition. This complexity is often ignored by RSs. In order to provide an effective decision-making support, a RS should be ``holistic'', i.e., it should rely on a complete representation of the user, encoding heterogeneous user features (such as personal interests, psychological traits, health data, social connections) that may come from multiple data sources. However, to obtain such holistic recommendations some steps are necessary: rst, we need to identify the goal of the decision-making process; then, we have to exploit common-sense and domain knowledge to provide the user with the most suitable suggestions that best t the recommendation scenario. In this article, we present a methodological framework that can drive researchers and developers during the design process of this kind of ``holistic'' RS. We also provide evidence of the framework validity by presenting the design process and the evaluation of a food RS based on holistic principles

Duplication of the posterior cerebral artery: two case reports

The anatomy of the brain circulation is complex and variable.Autopsy studies and imaging techniques have detected anatomical variations of cerebral arteries (CAs) in 48–58% of the general population [1]. The duplication of the posterior cerebral artery (PCA) is a rare anatomic variant with a frequency of 2.3% [2, 3]. PCA duplication is characterised by the identification of a “true foetal” PCA, that originates from the internal carotid artery (ICA) and gives rise to the parieto-occipital artery, the internal occipital artery, the calcarine artery and the posterior pericallosal artery, associated with a PCA, that regularly arises from the basilar artery and gives rise to the posterior temporal artery [4]

Hydrocarbons removal from wastewater by adsorption onto biochar from Posidonia oceanica

Environmental pollution by petroleum derivatives is a very current topic. In particular, low concentration of this kind of pollutants can seriously compromise the life of animals and plants of aquatic ecosystems [1]. For this reason, recent environmental legislation imposes severe restriction to oil-in-water content for overboard discharge with concentration limits from 15 to 5 ppm [2]. The shipping industry is trying to adapt to these directives by equipping ships with cleaning treatment devices in which there are several oil removal steps. Usually, the last step of bilge water treatment is based on adsorption onto suitable adsorbent materials that must be able to remove the last and most dispersed oil fraction reducing its concentration within legal limits. In this work, a biochar obtained from pyrolysis of Posidonia oceanica, a Mediterranean sea plant, has been tested as adsorbent material of a synthetic bilge water. The pristine biochar (BCP) was tested as it was and after two chemical activation treatments with sulfuric acid (BCA) and potassium hydroxide (BCB). The adsorbent materials have been characterized by using different techniques (TGA, SEM-EDAX, FT-IR, etc) and their adsorption capacity was studied by batch and column experiments. Oil concentration measurements were performed by using: HPLC-FLD and TOC techniques

L\u2019Aquila, 6 aprile 2009: la gestione dell\u2019emergenza, la promozione della coesione e della salute sociale

Il presente lavoro nasce nell\u2019ambito del Progetto Vela, che si pone come obiettivo generale "la promozione della salute\u201d in comunit\ue0 colpite da emergenza sia naturale che umanitaria. Il Progetto \ue8 un\u2019iniziativa elaborata da un gruppo di ricercato- ri afferenti all\u2019Universit\ue0 degli Studi di Padova (dipartimento FISPPA \u2013 Filosofia, Sociologia, Pedagogia e Psicologia Applicata), nato nell\u2019ottobre 2011 con l\u2019obietti- vo di indagare quali siano state le ricadute negli assetti interattivi della comunit\ue0 aquilana, ossia come essa configuri la propria realt\ue0 sociale, in seguito al sisma del 6 aprile 2009. L\u2019incipit dell\u2019articolo consiste in una riflessione teorico-conoscitiva sulla relazione tra \u201ccatastrofe\u201d, \u201csalute\u201d ed \u201cemergenza\u201d, che ha porta-to ad assumere la rilevanza di indagarli per come sono configurati dai membri della comunit\ue0, anzich\ue9 considerarli entit\ue0 statiche di per s\ue9. Coerentemente con questi assunti, attraverso appositi protocolli di indagine, sono state indagate le modalit\ue0 discorsive che configurano la "salute" del territorio aquilano prima del sisma, nelle ore di urgenza del post-sisma, allo stato attuale e in proiezione futura. I protocolli sono stati somministrati a diversi ruoli (cittadini, commercianti, insegnanti, forze dell\u2019ordine, operatori della protezione civile, medici e psicologi), in modo da raccogliere il testo di tutte le voci della comunit\ue0 aquilana. Quanto emerso ha mostrato che gli aquilani tuttora configurano la loro comunit\ue0 come "catastrofica" e dunque associata all\u2019evento sismico; dunque quest\u2019ultimo ha pervaso, e pervade, la biografia della comunit\ue0 aquilana (sia in prospettiva passata, che presente, che futura) con alto tasso di potenziale disgregazione sociale

Spider bites of medical significance in the mediterranean area: misdiagnosis, clinical features and management

Despite the disrepute spiders have had for centuries, their bite is a rare occurrence. In the Mediterranean area, only two of the numerous known species are considered of medical significance: Latrodectus tredecimguttatus and Loxosceles rufescens. Spider bites have no pathognomonic signs or symptoms, therefore most diagnoses are presumptive; a spider bite can only be diagnosed when a spider (seen at the time of the bite) is collected and identified by an expert, since most physicians and patients are unable to recognize a certain spider species or distinguish spiders from other arthropods. Skin lesions of uncertain etiology are too often attributed to spider bites. In most cases, these are actually skin and soft-tissue infections, allergic reactions, dermatoses etc. Misdiagnosing a wound as a spider bite can lead to delays in appropriate care, cause adverse or even fatal outcomes and have medical-legal implications. Concerningly, misinformation on spider bites also affects the medical literature and it appears there is lack of awareness on current therapeutic indications for verified bites

TCT-737 MONITORING THE LEARNING CURVE AND QUALITY OF CARE IN TAVI PROCEDURES BY CUSUM ANALYSIS

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Domestic dogs (Canis familiaris) grieve over the loss of a conspecific.

Behavioural reactions towards a dead conspecific have been observed rarely in wild canids and there is no documented scientific evidence of grief in pet dogs. A quantitative analysis of grief-related responses in both dogs and owners was conducted, using the validated online Mourning Dog Questionnaire. The survey was completed by 426 Italian adults who had owned at least two dogs, one of whom died while the other was still alive. This research aims to explore whether, how and what a dog may experience over the loss of a companion dog. Multiple logistic regression indicates that both a friendly or parental relationship between two dogs but also the fact that dogs used to share food and the owner's grief and anger are principal predictors of negative behavioural changes. According to dog owners' answers, the surviving dog after the death of the companion dog changed both in terms of activities ("playing", "sleeping", and "eating") and emotions (fearfulness), which occurred as a function of the quality of the relationship between the two animals. By contrast, the time the two dogs had spent together had no effect on the behaviours of surviving dog. Owner perceptions about their dog's reactions and emotions were not related to the memory or suffering of the event that tended to diminish over time. These findings indicate that a dog may show grief-related behavioural and emotional patterns when a close conspecific dies, with aspects of the latter possibly related to the owner's emotional status

Nuclear lipid microdomains regulate daunorubicin resistance in hepatoma cells

Daunorubicin is an anticancer drug, and cholesterol is involved in cancer progression, but their relationship has not been defined. In this study, we developed a novel experimental model that utilizes daunorubicin, cholesterol, and daunorubicin plus cholesterol in the same cells (H35) to search for the role of nuclear lipid microdomains, rich in cholesterol and sphingomyelin, in drug resistance. We find that the daunorubicin induces perturbation of nuclear lipid microdomains, localized in the inner nuclear membrane, where active chromatin is anchored. As changes of sphingomyelin species in nuclear lipid microdomains depend on neutral sphingomyelinase activity, we extended our studies to investigate whether the enzyme is modulated by daunorubicin. Indeed the drug stimulated the sphingomyelinase activity that induced reduction of saturated long chain fatty acid sphingomyelin species in nuclear lipid microdomains. Incubation of untreated-drug cells with high levels of cholesterol resulted in the inhibition of sphingomyelinase activity with increased saturated fatty acid sphingomyelin species. In daunodubicin-treated cells, incubation with cholesterol reversed the action of the drug by acting via neutral sphingomyelinase. In conclusion, we suggest that cholesterol and sphingomyelin-forming nuclear lipid microdomains are involved in the drug resistance

Hypogonadism and Sexual Dysfunction in Testicular Tumor Survivors: A Systematic Review

Testicular tumor is the most common malignancy in men of reproductive age. According to the tumor histology and staging, current treatment options include orchiectomy alone or associated with adjuvant chemo- and/or radiotherapy. Although these treatments have considerably raised the percentage of survivors compared to the past, they have been identified as risk factors for testosterone deficiency and sexual dysfunction in this subgroup of men. Male hypogonadism, in turn, predisposes to the development of metabolic and cardiovascular impairment that negatively affects general health. Accordingly, longitudinal studies report a long-term risk for cardiovascular diseases after radiotherapy and/or cisplatin-based chemotherapy in testicular tumor survivors. The aim of this review was to summarize the current evidence on hypogonadism and sexual dysfunction in long-term cancer survivors, including the epidemiology of cardiovascular and metabolic disorders, to increase the awareness that serum testosterone levels, sexual function, and general health should be evaluated during the endocrinological management of these patients

Domestic dogs (Canis familiaris) grieve over the loss of a conspecific

Behavioural reactions towards a dead conspecific have been observed rarely in wild canids and there is no documented scientific evidence of grief in pet dogs. A quantitative analysis of grief-related responses in both dogs and owners was conducted, using the validated online Mourning Dog Questionnaire. The survey was completed by 426 Italian adults who had owned at least two dogs, one of whom died while the other was still alive. This research aims to explore whether, how and what a dog may experience over the loss of a companion dog. Multiple logistic regression indicates that both a friendly or parental relationship between two dogs but also the fact that dogs used to share food and the owner’s grief and anger are principal predictors of negative behavioural changes. According to dog owners’ answers, the surviving dog after the death of the companion dog changed both in terms of activities (“playing”, “sleeping”, and “eating”) and emotions (fearfulness), which occurred as a function of the quality of the relationship between the two animals. By contrast, the time the two dogs had spent together had no effect on the behaviours of surviving dog. Owner perceptions about their dog’s reactions and emotions were not related to the memory or suffering of the event that tended to diminish over time. These findings indicate that a dog may show grief-related behavioural and emotional patterns when a close conspecific dies, with aspects of the latter possibly related to the owner’s emotional status