Viking '75 spacecraft design and test summary. Volume 1: Lander design

The Viking Mars program is summarized. The design of the Viking lander spacecraft is described

Viking '75 spacecraft design and test summary. Volume 3: Engineering test summary

The engineering test program for the lander and the orbiter are presented. The engineering program was developed to achieve confidence that the design was adequate to survive the expected mission environments and to accomplish the mission objective

Non-malleable codes for space-bounded tampering

Non-malleable codes—introduced by Dziembowski, Pietrzak and Wichs at ICS 2010—are key-less coding schemes in which mauling attempts to an encoding of a given message, w.r.t. some class of tampering adversaries, result in a decoded value that is either identical or unrelated to the original message. Such codes are very useful for protecting arbitrary cryptographic primitives against tampering attacks against the memory. Clearly, non-malleability is hopeless if the class of tampering adversaries includes the decoding and encoding algorithm. To circumvent this obstacle, the majority of past research focused on designing non-malleable codes for various tampering classes, albeit assuming that the adversary is unable to decode. Nonetheless, in many concrete settings, this assumption is not realistic

Influence of Dietary Incorporation of Bloodmeal on Nursery Pig Manure Composition and Odor

Specific dietary ingredients may have the potential to alter manure odor by altering digestive patterns or fermentation or by masking manure odorants. Inclusion of dietary bloodmeal (BM) into nursery pig diets resulted in a slight, but insignificant, increase in manure odor intensity. Electronic nose response to manure odor moderately mimicked human response

Evaluating LAB@FUTURE, a collaborative e-learning Laboratory experiments platform

This paper presents Lab@Future, an advanced e-learning platform that uses novel Information and Communication Technologies to support and expand laboratory teaching practices. For this purpose, Lab@Future uses real and computer generated objects that are interfaced using mechatronic systems, augmented reality, mobile technologies and 3D multi user environments. The main aim is to develop and demonstrate technological support for practical experiments in the following focused disciplines namely: Fluid Dynamics - Science subject in Germany, Geometry - Mathematics subject in Austria, History and Environmental Awareness – Arts and Humanities subjects in Greece and Slovenia. In order to pedagogically enhance the design and functional aspects of this e-learning technology, we are investigating the dialogical operationalisation of learning theories so as to leverage our understanding of teaching and learning practices in the targeted context of deployment. To be able to evaluate the lab@future system in its entire complexity an evaluation methodology including several phases has been developed, performing formative as well as summative evaluations

Suspected sepsis: summary of NICE guidance

The UK Parliamentary and Health Service Ombudsman inquiry “Time to Act” found failures in the recognition, diagnosis, and early management of those who died from sepsis, which triggered this guidance. In sepsis the body’s immune and coagulation systems are switched on by an infection and cause one or more body organs to malfunction with variable severity. The condition is life threatening. Although most people with infection do not have and will not develop sepsis, non-specific signs and symptoms can lead to late recognition of people who might have sepsis. We would like clinicians to “think sepsis” and recognise symptoms and signs of potential organ failure when they assess someone with infection, in a similar way to thinking “Could this chest pain be cardiac in origin?”This guidance provides a pragmatic approach for patients with infection who are assessed in the community, emergency departments, and hospitals by a wide range of general and specialist healthcare professionals. It includes guidance on assessment of risk factors followed by a detailed structured assessment of potential clinical signs and symptoms of concern.Definitions of sepsis have been developed, but these offer limited explanation on how to confirm or rule out the diagnosis in general clinical settings or in the community. Current mechanisms to diagnose sepsis and guidelines for use largely apply to critical care settings such as intensive care. We recognised a need for better recognition of sepsis in non-intensive settings and for the diagnosis to be entertained sooner.While sepsis is multifactorial and rarely presents in the same way, the Guideline Development Group considered that use of an easy, structured risk assessment may help clinicians identify those most severely ill who require immediate potentially lifesaving treatment. This guideline ensures that patients defined as having sepsis by recent definitions are, as a minimum, assessed as moderate-high risk. This guidance is also about appropriate de-escalation if sepsis is unlikely and broad spectrum antibiotics or hospital admission are not appropriate.This article summarises recommendations from the National Institute for Health and Care Excellence (NICE) guideline for the recognition, diagnosis, and management of sepsis in children and adults. Recommendations and the clinical pathway are available via the NICE website, and the UK Sepsis Trust tools are being revised to align with this guidance. This article is accompanied by an infographic, which displays the NICE guideline as a decision making tool

Pneumococcal Serotype-Specific Antibodies Persist through Early Childhood after Infant Immunization: Follow-Up from a Randomized Controlled Trial

Background: In a previous UK multi-center randomized study 278 children received three doses of 7-valent (PCV-7) or 13- valent (PCV-13) pneumococcal conjugate vaccine at 2, 4 and 12 months of age. At 13 months of age, most of these children had pneumococcal serotype-specific IgG concentrations $0.35 mg/ml and opsonophagocytic assay (OPA) titers$8. Methods: Children who had participated in the original study were enrolled again at 3.5 years of age. Persistence of immunity following infant immunization with either PCV-7 or PCV-13 and the immune response to a PCV-13 booster at preschool age were investigated. Results: In total, 108 children were followed-up to the age of 3.5 years and received a PCV-13 booster at this age. At least 76% of children who received PCV-7 or PCV-13 in infancy retained serotype-specific IgG concentrations $0.35 mg/ml against each of 5/7 shared serotypes. For serotypes 4 and 18C, persistence was lower at 22–42$0.35 mg/ml against each of 4/6 of the additional PCV-13 serotypes; for serotypes 1 and 3 this proportion was 45% and 52%. In the PCV-7 group these percentages were significantly lower for serotypes 1, 5 and 7F. A pre-school PCV-13 booster was highly immunogenic and resulted in low rates of local and systemic adverse effects. Conclusion: Despite some decline in antibody from 13 months of age, these data suggest that a majority of pre-school children maintain protective serotype-specific antibody concentrations following conjugate vaccination at 2, 4 and 12 months of age. Trial Registration: ClinicalTrials.gov NCT0109547

Validation of a Parkinson disease predictive model in a population-based study

Parkinson disease (PD) has a relatively long prodromal period that may permit early identification to reduce diagnostic testing for other conditions when patients are simply presenting with early PD symptoms, as well as to reduce morbidity from fall-related trauma. Earlier identification also could prove critical to the development of neuroprotective therapies. We previously developed a PD predictive model using demographic and Medicare claims data in a population-based case-control study. The area under the receiver-operating characteristic curve (AUC) indicated good performance. We sought to further validate this PD predictive model. In a randomly selected, population-based cohort of 115,492 Medicare beneficiaries aged 66–90 and without PD in 2009, we applied the predictive model to claims data from the prior five years to estimate the probability of future PD diagnosis. During five years of follow-up, we used 2010–2014 Medicare data to determine PD and vital status and then Cox regression to investigate whether PD probability at baseline was associated with time to PD diagnosis. Within a nested case-control sample, we calculated the AUC, sensitivity, and specificity. A total of 2,326 beneficiaries developed PD. Probability of PD was associated with time to PD diagnosis (p<0.001, hazard ratio = 13.5, 95% confidence interval (CI) 10.6–17.3 for the highest vs. lowest decile of probability). The AUC was 83.3% (95% CI 82.5%–84.1%). At the cut point that balanced sensitivity and specificity, sensitivity was 76.7% and specificity was 76.2%. In an independent sample of additional Medicare beneficiaries, we again applied the model and observed good performance (AUC = 82.2%, 95% CI 81.1%–83.3%). Administrative claims data can facilitate PD identification within Medicare and Medicare-aged samples

Simulating Auxiliary Inputs, Revisited

For any pair $(X,Z)$ of correlated random variables we can think of $Z$ as a randomized function of $X$. Provided that $Z$ is short, one can make this function computationally efficient by allowing it to be only approximately correct. In folklore this problem is known as \emph{simulating auxiliary inputs}. This idea of simulating auxiliary information turns out to be a powerful tool in computer science, finding applications in complexity theory, cryptography, pseudorandomness and zero-knowledge. In this paper we revisit this problem, achieving the following results: \begin{enumerate}[(a)] We discuss and compare efficiency of known results, finding the flaw in the best known bound claimed in the TCC'14 paper "How to Fake Auxiliary Inputs". We present a novel boosting algorithm for constructing the simulator. Our technique essentially fixes the flaw. This boosting proof is of independent interest, as it shows how to handle "negative mass" issues when constructing probability measures in descent algorithms. Our bounds are much better than bounds known so far. To make the simulator $(s,\epsilon)$-indistinguishable we need the complexity $O\left(s\cdot 2^{5\ell}\epsilon^{-2}\right)$ in time/circuit size, which is better by a factor $\epsilon^{-2}$ compared to previous bounds. In particular, with our technique we (finally) get meaningful provable security for the EUROCRYPT'09 leakage-resilient stream cipher instantiated with a standard 256-bit block cipher, like $\mathsf{AES256}$.Comment: Some typos present in the previous version have been correcte