Are patient specific meshes required for EIT head imaging?

Head imaging with electrical impedance tomography (EIT) is usually done with time-differential measurements, to reduce time-invariant modelling errors. Previous research suggested that more accurate head models improved image quality, but no thorough analysis has been done on the required accuracy. We propose a novel pipeline for creation of precise head meshes from magnetic resonance imaging and computed tomography scans, which was applied to four different heads. Voltages were simulated on all four heads for perturbations of different magnitude, haemorrhage and ischaemia, in five different positions and for three levels of instrumentation noise. Statistical analysis showed that reconstructions on the correct mesh were on average 25% better than on the other meshes. However, the stroke detection rates were not improved. We conclude that a generic head mesh is sufficient for monitoring patients for secondary strokes following head trauma

EIT-MESHER – Segmented FEM Mesh Generation and Refinement

EIT-MESHER (https://github.com/EIT-team/Mesher) is C++ software, based on the CGAL library, which generates high quality Finite Element Model tetrahedral meshes from binary masks of 3D volume segmentations. Originally developed for biomedical applications in Electrical Impedance Tomography (EIT) to address the need for custom, non-linear refinement in certain areas (e.g. around electrodes), EIT-MESHER can also be used in other fields where custom FEM refinement is required, such as Diffuse Optical Tomography (DOT)

Anomalous Zero Sound

We show that the anomalous term in the current, recently suggested by Son and Yamamoto, modifies the structure of the zero sound mode in the Fermi liquid in a magnetic field.Comment: 14 pages, 2 figure

Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells

Background: Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastasis. We recently reported that the chemokine receptor CCR7, a multi-functional regulator of breast cancer, maintains the stem-like cell population. Methods: This study used a combination of molecular and cellular assays on primary mammary tumor cells from the MMTV-PyMT transgenic mouse with or without CCR7 to examine the signaling crosstalk between CCR7 and Notch pathways. Results: We show for the first time that CCR7 functionally intersects with the Notch signaling pathway to regulate mammary cancer stem-like cells. In this cell subpopulation, CCR7 stimulation activated the Notch signaling pathway, and deletion of CCR7 significantly reduced the levels of activated cleaved Notch1. Moreover, blocking Notch activity prevented specific ligand-induced signaling of CCR7 and augmentation of mammary cancer stem-like cell function. Conclusion: Crosstalk between CCR7 and Notch1 promotes stemness in mammary cancer cells and may ultimately potentiate mammary tumor progression. Therefore, dual targeting of both the CCR7 receptor and Notch1 signaling axes may be a potential therapeutic avenue to specifically inhibit the functions of breast cancer stem cells.Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkov

Stellar spectroscopy: Fermions and holographic Lifshitz criticality

Electron stars are fluids of charged fermions in Anti-de Sitter spacetime. They are candidate holographic duals for gauge theories at finite charge density and exhibit emergent Lifshitz scaling at low energies. This paper computes in detail the field theory Green's function G^R(w,k) of the gauge-invariant fermionic operators making up the star. The Green's function contains a large number of closely spaced Fermi surfaces, the volumes of which add up to the total charge density in accordance with the Luttinger count. Excitations of the Fermi surfaces are long lived for w <~ k^z. Beyond w ~ k^z the fermionic quasiparticles dissipate strongly into the critical Lifshitz sector. Fermions near this critical dispersion relation give interesting contributions to the optical conductivity.Comment: 38 pages + appendices. 9 figure

Holographic non-relativistic fermionic fixed point by the charged dilatonic black hole

Driven by the landscape of garden-variety condensed matter systems, we have investigated how the dual spectral function behaves at the non-relativistic as well as relativistic fermionic fixed point by considering the probe Dirac fermion in an extremal charged dilatonic black hole with zero entropy. Although the pattern for both of the appearance of flat band and emergence of Fermi surface is qualitatively similar to that given by the probe fermion in the extremal Reissner-Nordstrom AdS black hole, we find a distinctly different low energy behavior around the Fermi surface, which can be traced back to the different near horizon geometry. In particular, with the peculiar near horizon geometry of our extremal charged dilatonic black hole, the low energy behavior exhibits the universal linear dispersion relation and scaling property, where the former indicates that the dual liquid is a Fermi one while the latter implies that the dual liquid is not exactly of Landau Fermi type

Mixed RG Flows and Hydrodynamics at Finite Holographic Screen

We consider quark-gluon plasma with chemical potential and study renormalization group flows of transport coefficients in the framework of gauge/gravity duality. We first study them using the flow equations and compare the results with hydrodynamic results by calculating the Green functions on the arbitrary slice. Two results match exactly. Transport coefficients at arbitrary scale is ontained by calculating hydrodynamics Green functions. When either momentum or charge vanishes, transport coefficients decouple from each other.Comment: 22 pages, 6 figure

Banishing AdS ghosts with a UV cutoff

A recent attempt to make sense of scalars in AdS with "Neumann boundary conditions" outside of the usual BF-window $-(d/2)^2 < m^2 l^2 < -(d/2)^2 + 1$ led to pathologies including (depending on the precise context) either IR divergences or the appearance of ghosts. Here we argue that such ghosts may be banished by imposing a UV cutoff. It is also possible to achieve this goal in certain UV completions. An example is the above AdS theory with a radial cutoff supplemented by particular boundary conditions on the cutoff surface. In this case we explicitly identify a region of parameter space for which the theory is ghost free. At low energies, this theory may be interpreted as the standard dual CFT (defined with "Dirichlet" boundary conditions) interacting with an extra scalar via an irrelevant interaction. We also discuss the relationship to recent works on holographic fermi surfaces and quantum criticality.Comment: 20 pages, 9 figure

Synthetic NLTE accretion disc spectra for the dwarf nova SS Cyg during an outburst cycle

Dwarf nova outbursts result from enhanced mass transport through the accretion disc of a cataclysmic variable system. We assess the question of whether these outbursts are caused by an enhanced mass transfer from the late-type main sequence star onto the white dwarf (so-called mass transfer instability model, MTI) or by a thermal instability in the accretion disc (disc instability model, DIM). We compute non-LTE models and spectra of accretion discs in quiescence and outburst and construct spectral time sequences for discs over a complete outburst cycle. We then compare our spectra to published optical spectroscopy of the dwarf nova SS Cygni. In particular, we investigate the hydrogen and helium line profiles that are turning from emission into absorption during the rise to outburst. The evolution of the hydrogen and helium line profiles during the rise to outburst and decline clearly favour the disc-instability model. Our spectral model sequences allow us to distinguish inside-out and outside-in moving heating waves in the disc of SS Cygni, which can be related to symmetric and asymmetric outburst light curves, respectively.Comment: 8 pages, 8 figures; accepted to A&