The differential effects of high-fat and high- -fructose diets on the liver of male albino rat and the proposed underlying mechanisms

Background: The Western-style diet is characterised by the high intake of energy- -dense foods. Consumption of either high-fructose diet or saturated fat resulted in the development of metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Many researchers studied the effect of high-fat diet (HFD), high-fructose diet (HFruD) and high-fructose high-fat diet (HFHF) on the liver. The missing data are the comparison effect of these groups i.e. are effects of the HFHF diet on the liver more pronounced? So, this study was designed to compare the metabolic and histopathological effect of the HFD, HFruD, and HFHF on the liver. The proposed underlying mechanisms involved in these changes were also studied.  Materials and methods: Twenty four rats were divided into four groups: con- trol, HFD, HFruD, and HFHF. Food was offered for 6 weeks. Biochemical, light microscopic, immunohistochemical (Inducible nitric oxide synthase [iNOS] and alpha-smooth muscle actin [α-SMA]), real-time polymerase chain reaction (gene expression of TNF-α, interleukin-6, Bax, BCL-2, and caspase 3), histomorphometric analysis and oxidative/antioxidative markers (thiobarbituric acid reactive substances [TBARS], malondialdehyde [MDA]/glutathione [GSH] and superoxide dismutase [SOD]) were done.  Results: The HFD, HFruD and HFHF groups developed a cluster of liver disorders; steatosis, necrosis, inflammation, apoptosis, ballooning degeneration and cytopla- smic vacuolations. Internal metabolic impairments include elevated serum levels of glucose, triglycerides, low density lipoprotein and decreased serum levels of high density lipoprotein and albumin. The immunoreaction of the α-SMA and iNOS was strong in these groups. The oxidant markers (MDA and TBARS) were elevated, while the antioxidant markers (SOD and GSH) were decreased. The area per cent of collagen, inflammatory markers, caspase 3 and Bax were elevated, while the BCL-2/Bax ratio was decreased. The decrease in PAS, antioxidant markers and the elevation of the α-SMA, iNOS, inflammatory and oxidant markers were obvious in the HFHF when compared to that of the other groups.  Conclusions: High-fat diet, HFruD, and HFHF developed morphologic hepatic changes ranging from steatosis to necrosis and inflammation, besides the deve- lopment of internal metabolic impairments. The chief factors of hepatic injury were fat accumulation in the hepatocytes, oxidative stress and highly elevated iNOS. Compared to the other groups, HFHF’s effect was more prominent.

Pengetahuan Metakognitif Belajar Siswa Kelas V SD

This research based on the results of preliminary observations on the grade V in SDN Pagergunung 03 found students who demonstrate learning metacognitive knowledge. Students know the thought processes in completing the task and know the weaknesses in learning. The aims of this research describe metacognitive knowledge of students of grade V is associated with three aspects: knowledge of strategy, knowledge of tasks and self-knowledge. The results of this research show that the metacognitive knowledge of students of grade V SDN Pagergunung 03 good enough. This result is said normal due to its development will continue with age.Penelitian ini dilatarbelakangi hasil observasi awal pada kelas V di SDN Pagergunung 03 ditemukan siswa yang menunjukkan pengetahuan metakognitif belajarnya. Siswa mengetahui proses berpikirnya dalam menyelesaikan tugas dan mengetahui kelemahan belajar yang ada pada dirinya. Penelitian ini bertujuan untuk mendeskripsikan pengetahuan metakognitif belajar siswa kelas V dikaitkan dengan tiga aspek yaitu aspek pengetahuan strategi, pengetahuan tugas, dan pengetahuan diri. Berdasarkan hasil penelitian menunjukkan bahwa pengetahuan metakognitif belajar siswa kelas V SDN Pagergunung 03 cukup baik. Keadaan ini dikatakan normal karena perkembangan pengetahuan metakognitif siswa akan terus berlanjut seiring bertambahnya usia

Pengembangan Motivasi Belajar Siswa Berprestasi Anak Tenaga Kerja Indonesia (Studi Kasus pada Siswa Sekolah Dasar di Kabupaten Blitar)

This article contains the result of research on the learning motivation development of student good achievement Indonesian labor in the elementary school district in Blitar. This research based on the good achievement students which is the parents were Indonesian labor. This research aims to know the good achievement students needs related to the study activities. This research used the qualitative approach with the case study draft. Based on the research, the study motivation of student good achievement can grow well. It's happen because the student good achievement needs related to the study activities are met.Artikel ini berisi hasil penelitian mengenai pengembangan motivasi belajar siswa berprestasi anak tenaga kerja Indonesia di Sekolah Dasar Kabupaten Blitar. Penelitian ini dilatarbelakangi oleh adanya prestasi belajar baik yang mampu di raih oleh siswa yang merupakan anak dari orangtua yang berstatus sebagai tenaga kerja Indonesia. Penelitian ini bertujuan untuk mengungkap kebutuhan-kebutuhan siswa berprestasi yang berkaitan dengan kegiatan belajar. Penelitian ini menggunakan pendekatan kualitatif dengan rancangan studi kasus. Berdasarkan hasil penelitian, motivasi belajar siswa berprestasi dapat tumbuh dengan baik. Hal ini dikarenakan kebutuhan-kebutuhan yang berkaitan dengan kegiatan belajar siswa berprestsai dapat terpenuhi

Do we need more than ultrasound endometrial thickness to predict malignancy?

Endometrial thickness (ET) ultrasound measurement has high diagnostic performance for detection of endometrial cancer in symptomatic postmenopausal women. Identified clinical risk factors, Doppler or 3D ultrasound parameters to predict endometrial malignancy had been proposed in several studies. We compared the accuracy of ultrasound endometrial thickness with scoring system/index involving both of clinical and ultrasound parameters to predict endometrial malignancy. Eight eligible diagnostic studies were appraised to assess the accuracy of ultrasound ET and/or ultrasound-based index to predict malignancy. The incidence of endometrial malignancy confirmed by histopathology examination was ranging from 10.5 to 58% from 8 studies. Ultrasound-based index to predict endometrial malignancy had good accuracy (AUC 75% - 98%). The addition of endometrial volume/uterine corpus volume ratio (EV/UCV) and Doppler to clinical parameters had increased the prediction accuracy of the index. While ultrasound ET alone has also high sensitivity, respectively 90.6% and 96.9% using the cut-off 4 mm and 3 mm with low accuracy. Ultrasound-based index to predict endometrial malignancy had better accuracy compared to ultrasound ET alone. Combination of ultrasound including Doppler parameters and clinical parameters had increased the prediction accuracy of the endometrial malignancy prediction index

Kurdish Sign Language Recognition System

Deaf people all around the world face difficulty to communicate with the others. Hence, they use their own language to communicate with each other. On the other hand, it is difficult for deaf people to get used to technological services such as websites, television, mobile applications, and so on. This project aims to design a prototype system for deaf people to help them to communicate with other people and computers without relying on human interpreters. The proposed system is for letter-based Kurdish Sign Language (KuSL) which has not been introduced before. The system would be a real-time system that takes actions immediately after detecting hand gestures. Three algorithms for detecting KuSL have been implemented and tested, two of them are well-known methods that have been implemented and tested by other researchers, and the third one has been introduced in this paper for the 1st time. The new algorithm is named Gridbased gesture descriptor. It turned out to be the best method for the recognition of Kurdish hand signs. Furthermore, the result of the algorithm was 67% accuracy of detecting hand gestures. Finally, the other well-known algorithms are named scale invariant feature transform and speeded-up robust features, and they responded with 42% of accuracy

Physiological Status of Fattening Bali Cattle Feeding a Concentrate Containing Gliricidia sepium Leaves Meal Fortified with Vitamin B-Complex and Vermicide

This research has been conducted at Oeletsala village, for 10 weeks from 23 November 2015 to 23 January 2016, comprised of 2 weeks preliminary and 8 weeks for data collection. The aim of the research was to study the effect of feeding a Gliricidia sepium leaves meal concentrate fortified with B. complex vitamin and vermicide on rectal temperature, respiratory frequency, and heart rate of fattening Bali cattle. Experimental animals used were nine young male Bali cattle of 1.5-2 years old, with an initial body weight ranging from 82 to 124 kg (KV=15.114%) in average of 98.7±14.93 kg. The experimental design used was Randomized Block Design with three treatments and three replications. Those treatments were R0 = leaves of Leucaena leucocephala and Ceiba pentandra+ native grass ad libitum (as commonly practiced by local farmers), R1 = R0 + 2 kg concentrate, and R2 = R1 + B. complex vitamin, and vermicide. Statistical analysis showed that there was no significant effect of the treatments on rectal temperature, respiratory frequency, and heart rate of the fattening Bali cattle(P ≤ 0.05).In conclusion, there was no significant effect of Gliricidia sepium leaves meal concentrate, vitamin B. complex, and vermicide on rectal temperature, respiratory frequency, and heart rate of the fattening Bali cattle. Keywords: concentrate, B complex vitamin, worm vermicide, rectal temperature, respiratory frequency, and heart rat

Updated systematic review and meta-analysis of the comparative data on colposuspensions, pubovaginal slings, and midurethral tapes in the surgical treatment of female stress urinary incontinence

Context Retropubic (RP-TVT) and transobturator miurethral (TO-TVT) midurethral sling (MUS) are popular surgical treatments for female stress urinary incontinence. The long-term efficacy and safety of the procedures is still a topic of intense clinical research and several randomised controlled trials (RCTs) have been published in the last years Objective To evaluate the efficacy and safety of MUS compared with other surgical treatments for female stress urinary incontinence. Evidence acquisition A systematic review and meta-analysis of the literature was performed using the Medline, Scopus, and Web of Science databases to update our previously published analyses. Evidence synthesis Twenty-eight RCTs were identified. In total, the meta-analyses included 15 855 patients. Patients receiving MUS had significantly higher overall (odds ratio [OR]: 0.59, p = 0.0003) and objective (OR: 0.51, p = 0.001) cure rates than those receiving Burch colposuspension. Patients undergoing MUS and pubovaginal slings had similar cure rates. Patients treated with RT-TVT had higher subjective (OR: 0.83, p = 0.03) and objective (OR: 0.82, p = 0.01) cure rates than those receiving TO-TVT. However, the latter had a lower risk of intraoperative bladder or vaginal perforation (OR: 2.4, p = 0.0002), pelvic haematoma (OR: 2.61, p = 0.002), urinary tract infections (OR: 1.31, p = 0.04) and voiding lower urinary tract symptoms (OR: 1.66, p = 0.002). Sensitivity analyses limited to RCTs with follow-up durations >60 mo demonstrated similar outcomes for RP-TVT and TO-TVT. No significant differences in efficacy were identified comparing inside-to-out and outside-to-in TO-TVT but vaginal perforations were less common with the former (OR: 0.21, p = 0.0002). Conclusions The present analysis confirms the superiority of MUS over Burch colposuspension. The studies comparing insertion of RT-TVT and TO-TVT showed higher subjective and objective cure rates for the RP-TVT but at the cost of higher risks of some complications and voiding lower urinary tract symptoms. Efficacy of inside-out and outside-in techniques of TO-TVT insertion was similar, although the risk of vaginal perforation was lower in the inside-to-out TO-TVT. Patient summary Retropubic and transobturator midurethral slings are a popular treatment for female stress urinary incontinence. The available literature suggest that those slings are either more effective or safer than other older surgical procedures. Retropubic tapes are followed with slightly higher continence rates as compared with the transobturator tapes but are associated with higher risk of intra- and postoperative complications