The Acute Effects of Postprandial Hypertriglyceridemia on Coagulation Parameters in Normal and Overweight Individuals

WOS: 000217526200008Postprandial hypertriglyceridemia may have a procoagulant effect and cause an activation of coagulation system. The measurement of postprandial triglyceride concentrations and coagulation parameters may give additional useful data besides the fasting measurement. Thus, we investigated the acute effects of hypertriglyceridemia after the meal in normal and overweight individuals. Fourteen overweight (Group I) and sixteen normal weight (Group II) voluntary participants were given fat-rich meal (700 kcal). Blood samples were obtained at fasting, 3rd and 6th hours. In both groups, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglyceride (TG), fibrinogen, prothrombin time (PT), activated partial thromboplastin time, factor VII (FVII), factor IX (FIX), protein C and, protein S activities were measured. As might be expected, TG levels were higher in the postprandial state than the fasting state in both groups and also Group I subjects had higher levels rather than Group II at all states. One of our important finding finding was that PT levels were shorter in Group I at the fasting, postprandial 3rd and 6th hours than Group II (P = 0.007, P = 0.033, P = 0.047 respectively). Moreover, FVII and FIX activities were found as higher in Group I at the postprandial 3rd hour (P = 0.047, P = 0.008 respectively). In conclusion, the high activities of FVII and FIX and short PT levels may predispose to thrombosis in Group I, especially at postprandial states

The Three Sisters of Fate in Multiple Sclerosis: Klotho (Clotho), Fibroblast Growth Factor-23 (Lachesis), and Vitamin D (Atropos)

BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). PURPOSE: This study is aimed at evaluating serum soluble Klt (sKlt), FGF-23, and 25-(OH)-vitamin D levels in multiple sclerosis (MS) patients. METHODS: Thirty-two relapsing-remitting MS patients (11 males and 21 females; mean age 38.3 years) and 31 age-sex matched healthy controls (12 males and 19 females; median age 38.5 years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald. RESULTS: Serum sKlt, FGF-23, and P levels were significantly higher in MS patients compared to the control group (p < 0.01, p < 0.01, and p = 0.02, respectively). Serum 25-(OH)-vitamin D and Ca levels were significantly lower in MS patients (p < 0.01 and p = 0.04, respectively). CONCLUSION: Klt, which is secreted from CP, could be a response to the inflammatory condition in MS. Elevated FGF-23 levels suppress 1α-hydroxylase and upregulates 24α-hydroxylase, which results in a decrease in 1,25-(OH)(2)D(3) levels. Thus, the neuroprotective and immunomodulatory effects of vitamin D might not be seen in MS patients