Dietary consumption, fluid consumption and risk of developing bladder cancer

This thesis focuses on three different parts: (1) An analyses of dietary consumption, diet diversity and risk of developing bladder cancer within a case-control study in China. This study showed that higher diet diversity, particularly a diet varied in fruit may reduce the risk of developing bladder cancer. In addition, there was a positive association between the consumption of red meat, organ meat, leafy vegetables, bulb vegetables or preserved vegetables may increase the risk of bladder cancer. The consumption of citrus fruits, stone fruits, vine fruits, flower vegetables, fresh fish, potatoes and dairy products may decrease the risk of developing bladder cancer. (2) A dose-response meta-analysis on the association between total fluid consumption and bladder cancer was conducted. The results of this study suggest a non-linear relationship between total fluid intake and bladder cancer risk in men. Also, the findings indicates that low to moderate fluid consumption was not associated with an increased risk of developing bladder cancer; although fluid consumption exceeding 8 cups per day might increase the risk of developing bladder cancer. (3) A pooled analysis on fluid consumption and risk of developing bladder cancer using individual patient data from the Bladder Cancer Epidemiology and Nutritional Determinant consortium. The results suggest that excess consumption of coffee per day may increase the risk of developing bladder cancer in men

Characterization and frequency of biofilms in adenotonsillitis: a retrospective study from a tertiary hospital in North-Eastern Nigeria

Background: Adenotonsillitis, a common condition characterized by inflammation of the adenoids and tonsils, is caused by bacterial and fungal pathogens. Biofilm formation has been linked to disease chronicity and antibiotic resistance. However, the role of biofilms in adenotonsillitis remains poorly understood. This study aims to explore biofilms in adenotonsillitis biopsies, focusing on their characterization, frequency, and demographic distribution by determining the expression of polysaccharides in the biofilm matrix using Congo red stain, determining the presence and frequency of bacterial as well as fungal biofilms in adenotonsillar tissue, investigating any potential associations with disease severity, and evaluating the age and sex distribution of patients with adenotonsillitis. Methods: This retrospective study analyzed formalin-fixed paraffin-embedded adenotonsillitis biopsies (n=50) collected from the university of Maiduguri teaching hospital. The expression of polysaccharides in the biofilm matrix was assessed using congo red stain. Bacterial and fungal biofilms were visualized using crystal violet and Gomori methenamine silver (GMS) stains, respectively. Data on patient demographics, diagnoses, and biofilm characteristics were analyzed. Results: Adenoidtonsillitis was the most common diagnosis (82%), predominantly affecting children aged 0-9 years (76%). Gram's reaction was positive in 70% of cases, while Congo red staining indicated polysaccharide expression in 60%. GMS staining revealed fungal elements in 18% of cases. Conclusions: This study sheds light on the characterization and frequency of bacterial and fungal biofilms in adenotonsillitis, emphasizing importance of biofilms in disease development and persistence. Understanding biofilm-associated infections can improve diagnostic and treatment strategies for adenotonsillitis in Nigeria and beyond

Detection of Offensive and Threatening Online Content in a Low Resource Language

Hausa is a major Chadic language, spoken by over 100 million people in Africa. However, from a computational linguistic perspective, it is considered a low-resource language, with limited resources to support Natural Language Processing (NLP) tasks. Online platforms often facilitate social interactions that can lead to the use of offensive and threatening language, which can go undetected due to the lack of detection systems designed for Hausa. This study aimed to address this issue by (1) conducting two user studies (n=308) to investigate cyberbullying-related issues, (2) collecting and annotating the first set of offensive and threatening datasets to support relevant downstream tasks in Hausa, (3) developing a detection system to flag offensive and threatening content, and (4) evaluating the detection system and the efficacy of the Google-based translation engine in detecting offensive and threatening terms in Hausa. We found that offensive and threatening content is quite common, particularly when discussing religion and politics. Our detection system was able to detect more than 70% of offensive and threatening content, although many of these were mistranslated by Google's translation engine. We attribute this to the subtle relationship between offensive and threatening content and idiomatic expressions in the Hausa language. We recommend that diverse stakeholders participate in understanding local conventions and demographics in order to develop a more effective detection system. These insights are essential for implementing targeted moderation strategies to create a safe and inclusive online environment.Comment: 25 pages, 5 figures, 8 table

Effectiveness of an electronic hand hygiene monitoring system on healthcare workers’ compliance to guidelines

SummaryHand hygiene is a growing concern among populations and is a crucial element in ensuring patient safety in a healthcare environment. Numerous management efforts have been conducted in that regard, including education, awareness and observations. To better evaluate the possible impact of technology on a healthcare setting, we observed the impact of a particular niche technology developed as an answer to the growing hand hygiene concerns. A study was conducted at Salmaniya Medical Complex (SMC) in Bahrain on a total of 16 Coronary Care Unit (CCU) beds where the system was installed, and the hand hygiene activity of healthcare workers (HCWs) in this area was monitored for a total period of 28 days. Comments, remarks and suggestions were noted, and improvements were made to the technology during the course of the trial. While resistance to change was significant, overall results were satisfactory. Compliance with hand hygiene techniques went from 38–42% to 60% at the beginning of the trial and then increased to an average of 75% at the end of the 28-day trial. In some cases, compliance peaked at 85% or even at 100%. Our case study demonstrates that technology can be used effectively in promoting and improving hand hygiene compliance in hospitals, which is one way to prevent cross-infections, especially in critical care areas

Qualitative study of barriers to cervical cancer screening among Nigerian women.

OBJECTIVES: To explore the barriers to cervical cancer screening, focusing on religious and cultural factors, in order to inform group-specific interventions that may improve uptake of cervical cancer screening programmes. DESIGN: We conducted four focus group discussions among Muslim and Christian women in Nigeria. SETTING: Discussions were conducted in two hospitals, one in the South West and the other in the North Central region of Nigeria. PARTICIPANTS: 27 Christian and 22 Muslim women over the age of 18, with no diagnosis of cancer. RESULTS: Most participants in the focus group discussions had heard about cervical cancer except Muslim women in the South Western region who had never heard about cervical cancer. Participants believed that wizardry, multiple sexual partners and inserting herbs into the vagina cause cervical cancer. Only one participant knew about the human papillomavirus. Among the Christian women, the majority of respondents had heard about cervical cancer screening and believed that it could be used to prevent cervical cancer. Participants mentioned religious and cultural obligations of modesty, gender of healthcare providers, fear of disclosure of results, fear of nosocomial infections, lack of awareness, discrimination at hospitals, and need for spousal approval as barriers to uptake of screening. These barriers varied by religion across the geographical regions. CONCLUSIONS: Barriers to cervical cancer screening vary by religious affiliations. Interventions to increase cervical cancer awareness and screening uptake in multicultural and multireligious communities need to take into consideration the varying cultural and religious beliefs in order to design and implement effective cervical cancer screening intervention programmes

Taurine and/or Camel Milk Mitigates Haemolysis and Malondialdehyde Concentration in Alzheimer Rats

Alzheimer’s disease (AD) is a devastating neurodegenerative disease, affecting all age groups. Malondialdehyde (MDA) concentration and haemolysis are important oxidative stress biomarkers, implicated in the pathogenesis of AD. The study aimed to evaluate taurine, camel milk (CM) and their combined effects on MDA concentration and haemolysis in AD rats. The animal groupings were; Normal saline (0.2 mL/mg bw); AlCl3 (100 mg/kg); CM (33 mL/kg); Taurine (50 mg/kg); AlCl3 (100 mg/kg) + CM (33 mL/kg); AlCl3 (100 mg/kg) + Taurine (50 mg/kg) and AlCl3 (100 mg/kg) + CM (33 mL/kg) + Taurine (50 mg/kg). Concentration of MDA and percentage haemolysis were determined for all groups. At 0.5% NaCl, haemolysis in AD rats (64.00 ± 1.27 %) was higher (p < 0.05) than in AD + CM (51.50 ± 2.96 %) and AD + CM + Taurine (52.00 ± 1.53%) rats. MDA concentration was lowered (p < 0.05) in taurine-treated rats than controls, but it increased with haemolysis in AD rats compared to other groups. Taurine and/or CM exhibited antioxidant activity by decreasing haemolysis and MDA concentration in AD groups, and may be beneficial in mitigating AD-induced oxidative stress changes

Molecular Detection of Influenza A(H1N1)Pdm09 Virus Among Chronic Kidney Disease Patients: A Peripheral Blood Sample Approach and Assessment of the Associated Risk Factors

Introduction: Chronic kidney disease (CKD) is a progressive loss of functional nephron characterized by various risk factors. Influenza virus has been found to cause rhabdomyolysis, which is toxic to the kidneys and can initiate or worsen CKD. This study aims to investigate the frequency and molecular detection of Influenza A(H1N1)Pdm09 Virus gene among CKD patients attending University of Maiduguri Teaching Hospital, Nigeria.Materials and Methods: Peripheral blood samples were collected from 150 CKD patients. One-step RT-PCR was performed for detection of influenza virus using the Centers for Disease Control and Prevention protocol. Relevant clinical data were collected in standardized questionnaires from each patient, and medical history was obtained from their hospital records.Results: Conventional PCR analysis revealed that 16% of the CKD patients tested positive for Inf A/Pdm H1N1. The virus frequency was found to be higher among patients in CKD stage 5 (end-stage CKD) and lower in CKD stage 3 (moderate CKD). Additionally, female CKD patients and those in the age group of 55-64 years showed a higher susceptibility to Inf A/Pdm H1N1 infection.Discussion: The study provides evidence of the presence of Inf A/Pdm H1N1 in CKD patients, aligning with previous research showing its involvement in kidney disease aggravation. CKD patients often exhibit immune dysregulation, which might facilitate the virus's invasion and persistence. Conclusion: This study provides evidence of an association between Influenza A(H1N1)Pdm09 viraemia and decreased kidney function among CKD patients. The findings highlight the importance of monitoring and preventing influenza infection in CKD patients to prevent further kidney damage

Influence of Spirituality and Modesty on Acceptance of Self-Sampling for Cervical Cancer Screening.

INTRODUCTION: Whereas systematic screening programs have reduced the incidence of cervical cancer in developed countries, the incidence remains high in developing countries. Among several barriers to uptake of cervical cancer screening, the roles of religious and cultural factors such as modesty have been poorly studied. Knowledge about these factors is important because of the potential to overcome them using strategies such as self-collection of cervico-vaginal samples. In this study we evaluate the influence of spirituality and modesty on the acceptance of self-sampling for cervical cancer screening. METHODOLOGY: We enrolled 600 participants in Nigeria between August and October 2014 and collected information on spirituality and modesty using two scales. We used principal component analysis to extract scores for spirituality and modesty and logistic regression models to evaluate the association between spirituality, modesty and preference for self-sampling. All analyses were performed using STATA 12 (Stata Corporation, College Station, Texas, USA). RESULTS: Some 581 (97%) women had complete data for analysis. Most (69%) were married, 50% were Christian and 44% were from the south western part of Nigeria. Overall, 19% (110/581) of the women preferred self-sampling to being sampled by a health care provider. Adjusting for age and socioeconomic status, spirituality, religious affiliation and geographic location were significantly associated with preference for self-sampling, while modesty was not significantly associated. The multivariable OR (95% CI, p-value) for association with self-sampling were 0.88 (0.78-0.99, 0.03) for spirituality, 1.69 (1.09-2.64, 0.02) for religious affiliation and 0.96 (0.86-1.08, 0.51) for modesty. CONCLUSION: Our results show the importance of taking cultural and religious beliefs and practices into consideration in planning health interventions like cervical cancer screening. To succeed, public health interventions and the education to promote it must be related to the target population and its preferences

Heuristic Evaluation Of i-Dyslex Tool for Dyslexia Screening

Early detection for dyslexia is crucial in order for children to receive early as well as proper treatment. There are various studies that have focused on early detection of dyslexia, however the results remain limited. Therefore, an easy and user-friendly dyslexia screening tool called i-Dyslex was developed. In order to make sure the tool is free from design and interface problems, heuristic evaluation has been carried out. This paper discusses the heuristic evaluation of i-Dyslex tool for dyslexia screening among expert evaluators. This study adopted ten Usability Heuristics to be included in the questionnaire. Overall result derived from the evaluation is above average mean score, which are neutral (3.00) in one domain. Several comments and feedback from the experts. Both the experts’ evaluation and the feedback were essentials for further improvement of the i-Dyslex tool to ensure meets the user requirement and expectation