SCORE Kardiyovasküler Risk Puanlama Sistemi ile Non-dipper Hipertansiyon Arasındaki İlişki

Amaç: Non-dipper kan basıncının (KB) uç organ hasarı ve ölümcül - ölümcül olmayan kardiyovasküler hastalıklarla (KVH) anlamlı şekilde ilişkili olduğu gösterilmiştir. Kardiyovasküler (KV) olay riskinde artış bulunan bireylerde sistematik KV risk değerlendirmesi önerilir. SCORE risk sistemi, ilk ölümcül aterosklerotik olayın 10 yıllık riskini değerlendirir. Bu çalışmanın amacı hipertansiyon (HT)hastalarında non-dipper KB ile SCORE risk sistemi arasındaki bir ilişki olup olmadığının araştırılmasıdır. Yöntemler: Bu çalışma retrospektif bir çalışmadır ve esansiyel HT tanısı konulan ardışık 213 hastayı içermektedir. Non-dipper ve dipper hasta grupları 24 saatlik ambulatuar kan basıncı izlemine (AKBİ) göre belirlendi. SCORE sistemine göre yaş, cinsiyet, sigara kullanımı, sistolik kan basıncı (SKB) ve total kolesterol (TK) gibi risk faktörleri kullanılarak 10 yıllık ölümcül KV olay riski hesaplandı. Bulgular: Non-dipper HT hasta grubunda SCORE risk sistemi anlamlı olarak yüksek saptandı (p=0.017). Ayrıca sigara içme alışkanlığı sıklığı ve TK değerleri non-dipper HT’li hasta grubunda anlamlı olarak daha yüksek saptandı. Diğer demografik, klinik ve laboratuvar parametreler iki grup arasında benzerdi. SCORE risk oranı ile gece sistolik ve diyastolik KB’leri arasında orta derecede olmasına rağmen anlamlı pozitif korelasyon izlendi (r = 0.354, p < 0.001; r =0.339, p<0.001; sırasıyla) Sonuç: Bu çalışmada ilk defa non-dipper HT ile SCORE risk sistemi arasında önemli bir ilişki olduğu gösterilmiştir. SCORE risk sistemi ile hesaplanan 10 yıllık fatal KV olay ihtimalinin non-dipper hasta grubunda daha yüksek saptanması, esansiyel HT tanılı hastaların AKBİ ile takibinin önemini ortaya çıkarmıştır

Secondary metabolites of hypericum species from the drosanthe and olympia sections

, fatihyayla/0000-0002-6490-6288; Jakstas, Valdas/0000-0001-7627-6263WOS: 000375936200012Eight Hypericum species native to Southern Turkey from Drosanthe and Olympia sections were investigated for the presence of several bioactive compounds, namely, hypericin, pseudohypericin, hyperforin, adhyperforin, the chlorogenic, neochlorogenic, caffeic and 2,4-dihydroxybenzoic acids, hyperoside, isoquercitrin, quercitrin, quercetin, avicularin, rutin, (+)-catechin, (-)-epicatechin, mangiferin, I3, II8-biapigenin, and amentoflavone for the first time. Plants were harvested at flowering, dried at room temperature, dissected into different tissues, and assayed for chemical contents. HPLC analysis of methanolic fractions displayed similar chemical profile and significant quantitative differences among the investigated taxa. the present results support the taxonomic value of hypericins, rutin, and mangiferin at the sectional level and make an important contribution to our current knowledge about Hypericum chemistry. Such kind of data could also be beneficial for explanation of the chemo-taxonomic utility of the corresponding compounds as well as phytochemical evaluation of the species tested. (C) 2016 SAAB. Published by Elsevier B.V. All rights reserved

Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve

Background: The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve. Methods: The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter 65 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups. Results: The mean age of the participants was 44.7 \ub1 15.4 years and average ascending aorta diameter was 3.2 \ub1 0.3 cm in dilatation negative group and 4.4 \ub1 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve. Conclusion: We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve

Volatile secondary metabolites of Hypericum tetrapterum and Hypericum bithynicum

The phytochemical analyses on the flowering aerial parts resulted in identification of 32 and 30 compounds which represent 100% of total volatile components in Hypericum tetrapterum and Hypericum bithynicum (Hypericaceae), respectively. Among the chemicals, methylpalmitate, p-menthone, linalool and α-santalene for H. tetrapterum and camphor, α-bisabolol, methylpalmitate and nerolidol for H. bithynicum were recognized as major volatile ingredients. Volatile profile of H. tetrapterum from Turkish origin had never been described and this is the first report on volatile chemistry of H. bithynicum. Chemotaxonomic significance of the tested compounds was also discussed

Secondary metabolites of seven Hypericum species growing in Turkey

, fatihyayla/0000-0002-6490-6288; Jakstas, Valdas/0000-0001-7627-6263WOS: 000386041500033PubMed: 26958815Context the genus Hypericum (Hypericaceae) has attracted remarkable scientific interest as its members have yielded many bioactive compounds. Objective the current study presents investigations on the accumulation of hypericin, pseudohypericin, hyperforin, adhyperforin, chlorogenic acid, neochlorogenic acid, caffeic acid, 2,4-dihydroxybenzoic acid, 13,118-biapigenin, hyperoside, isoquercitrin, quercitrin, quercetin, avicularin, rutin, (+)-catechin and (-)-epicatechin in seven Hypericum (Hypericaceae) species growing wild in Turkey, namely, H. aviculariifolium Jaup. and Spach subsp. aviculariifolium (Freyn and Bornm.) Robson var. albiflorum (endemic), H. bithynicum Boiss., H. calycinum L., H. cardiophyllum Boiss., H. elongatum L. subsp. microcalycinum (Boiss. and Heldr.) Robson, H. hirsutum L. and H. xylosteifolium (Spach) N. Robson. Materials and methods the plant materials were collected at flowering period and dissected in different tissues. Air-dried plant material including stems, leaves and flowers was mechanically powdered with a laboratory mill and samples (0.1 g) were extracted in 10 mL of 100% methanol by ultrasonication at 40 degrees C for 30 min for HPLC-PDA analyses. Results Accumulation levels of the investigated compounds varied greatly depending on species and plant part. Discussion For the first time, the detailed chemical profiles of corresponding Turkish Hypericum species were reported and the results were discussed from a phytochemical point of view. Conclusions the present data have importance in evaluation of plant resources of Hypericum genus in selecting the new potential sources of bioactive compounds

Altitudinal changes in secondary metabolite contents of Hypericum androsaemum and Hypericum polyphyllum

, fatihyayla/0000-0002-6490-6288; Jakstas, Valdas/0000-0001-7627-6263WOS: 000397377900015The genus Hypericum (Hypericaceae) has attracted scientific interest as its members have yielded many bioactive compounds. in the present study we investigated the content of hypericin, pseudohypericin, hyperforin, adhyperforin, chlorogenic acid, neochlorogenic acid, caffeic acid, 2,4-dihydroxybenzoic acid, 13,II8-biapigenin, hyperoside, isoquercitrin, quercitrin, quercetin, avicularin, rutin, (+)-catechin arid (-)-epicatechin in aerial parts of plants from populations of H. androsaemum L and H. polyphyllum Boiss. & Bal. from Turkey growing at different altitudes. the plant materials were dried and subsequently assayed for chemical content by HPLC. All the tested compounds were detected in both species at varying levels depending upon the altitude the plants were growing, except for hypercins and rutin which did not accumulate in H. androsaemum. It was observed that overall the compounds were more abundant in plants from higher altitudes. the differences in the levels of the compounds could contribute to the ability of the plants to deal with the abiotic stress of lower temperature and higher ultraviolet (UV)-B radiation which would be greater at higher altitudes compared to lower altitudes. (C) 2016 Elsevier Ltd. All rights reserved

Does the cardiovascular drug levosimendan prevent iodinated contrast medium nephrotoxicity with glycerol aggravation in rats?

Background We investigated whether levosimendan prevents contrast medium nephrotoxicity with glycerol aggravation in rats. Methods Forty-eight Wistar albino rats were assigned to eight groups (n = 6 x 8). No medication was administered to group I (controls); glycerol (intramuscular injection of 25% glycerol, 10 mL/kg) group II; intravenous iohexol 10 mL/kg to group III; glycerol and iohexol to group IV; iohexol and intraperitoneal levosimendan 0.25 mg/kg to group V; glycerol, iohexol, and levosimendan 0.25 mg/kg to group VI; iohexol and levosimendan 0.5 mg/kg to group VII; and glycerol, iohexol, and levosimendan 0.5 mg/kg to group VIII. One-day water withdrawal and glycerol injection prompted renal damage; iohexol encouraged nephrotoxicity; levosimendan was administered 30 min after glycerol injection and continued on days 2, 3, and 4. The experiment was completed on day 5. Serum blood urea nitrogen (BUN) and creatinine levels, superoxide dismutase (SOD) activity, glutathione (GSH), malondialdehyde (MDA) levels, tumour necrosis factor-alpha (TNF-alpha), nuclear factor kappa ss (NFK-ss), interleukin 6 (IL-6), and histopathological marks were assessed. One-way analysis of variance and Duncan's multiple comparison tests were used. Results Levosimendan changed serum BUN (p = 0.012) and creatinine (p = 0.018), SOD (p = 0.026), GSH (p = 0.012), and MDA (p = 0.011). Levosimendan significantly downregulated TNF-alpha (p = 0.022), NFK-ss (p = 0.008), and IL-6 (p = 0.033). Histopathological marks of hyaline and haemorrhagic cast were improved in levosimendan-injected groups. Conclusion Levosimendan showed nephroprotective properties due to its vasodilator, oxidative distress decreasing and inflammatory cytokine preventing belongings

Cavum septum pellucidum nomogram during the second trimester of pregnancy

This study aimed to determine cavum septum pellucidum (CSP) nomogram values between 15–28 weeks of gestation. Routine biometric measurements and CSP width were measured by transabdominal ultrasonography in 6042 structurally normal foetuses between 15–28 weeks of gestation. Distribution of CSP width by the week of pregnancy and percentile values were calculated. The mean week of gestation (GW) was 21 ± 1.7, and the mean biparietal diameter (BPD) was 50.2 ± 5.8 mm. The CSP width range was 1.6–7.7 mm at 15–28 weeks, and the mean CSP width was 4.1 ± 0.8 mm. CSP width was found to have a significant correlation between a gestational week (CSP = GW X 0.2705–1.6121; R = 0.62; p < .01) and BPD (CSP = BPD X 0.0859–0.273; R = 0.651; p 0.01). CSP width was found to differ significantly according to gestational weeks, and percentile distributions were calculated. Between 15 and 28 weeks of gestation, the 95th percentile values of CSP width were found to be 3.7–7 mm. Our study was determined that CSP width increased linearly between 15–28 weeks of gestation. For this reason, we think that it would be more appropriate to use CSP width percentile values in the examination of the foetus. Impact statement What is already known on this subject? The cavum septum pellucidum can be easily identified and evaluated by ultrasonography after 18 weeks of pregnancy. CSP can be associated with severe brain anomalies if it is not visualised or deformed. Moreover; large CSP may be associated with chromosomal abnormalities. What do the results of this study add? Our study showed that CSP width increased linearly between 15–28 weeks of gestation. CSP width was found to differ significantly according to gestational weeks, and between 15 and 28 weeks of gestation, the 95th percentile values of CSP width were found to be 3.7–7 mm. What are the implications of these findings for clinical practice and/or further research? We reported that it would be more appropriate to use CSP percentile values according to the gestational week in the definition of abnormal CSP