Comparison of anti-Mullerian Hormone average between laparoscopic and treatment with clomiphene citrate in patients with polycystic ovarian syndrome

زمینه و هدف: آنتی مولرین هورمون (AMH) در پاتوژنز سندرم پلی کیستیک تخمدان درگیر می باشد. هدف ما مقایسه میانگین AMH در 2 روش لاپاروسکوپی و درمان با کلومیفن سیترات جهت سنجش پاسخ تخمدانی بود. روش بررسی: این مطالعه کارآزمایی بالینی بر روی زنان با سندرم پلی کیستیک تخمدان بدون تخمک گذاری انجام شد. بیماران به 2 گروه تحت مداوا با روش لاپاروسکوپی (49 نفر) و تحت درمان با کلومیفن سیترات (20 نفر) تقسیم گردیدند. غلظت های پلاسمایی AMH قبل از عمل و یک هفته بعد از آن و همچنین 3 و 6 ماه بعد از درمان انداره گیری شد. برای مقایسه میانگین ها در بین گروه ها از آنالیز ANOVA استفاده شد. یافته ها: میزان AMH قبل از مداوا در زنان تحت درمان با لاپاراسکوپی (1/4±1/6) و کلومیفن سیترات (2/3±7/5) تفاوت معنی دار نداشت (05/0<P). بعد از لاپاروسکوپی میزان AMH در بیماران پاسخ دهنده به درمان (1/2±6/5) در مقایسه با بیمارانی که به درمان پاسخ ندادند (3/1±9)، تفاوت معنی داری نشان داد (05/0>P). میزان AMH در بیماران تحت درمان کلومیفن سیترات در این مدت کاهش معنی داری نداشت. نتیجه گیری: درمان لاپاروسکوپی در بیمارانی که سطح AMH آن ها قبل از درمان پایین تر است، موفقیت آمیز می باشد

Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome

Background The objectives of study were to investigate the effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome (PCOS). Methods This double-blind randomized controlled clinical trial was conducted on 84 overweight or obese PCOS patients; aged 20�38 years. Subjects in cinnamon (n = 42) and placebo (n = 42) groups were given 3 cinnamon capsules (each one contained 500 mg cinnamon) or placebo daily for 8 weeks. Fasting blood samples, anthropometric measurements and dietary intake data were gathered at the beginning and at the end of the study. Independent t test, paired t test and analysis of covariance were used to analyze of data. Results Cinnamon significantly increased serum total antioxidant capacity (P = 0.005). Malondialdehyde was significantly decreased compared with placebo (P = 0.014). Cinnamon supplementation significantly improved serum level of total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (all P < 0.05). No significant effect was detected on serum triglyceride level. Conclusions Cinnamon supplementation improved antioxidant status and serum lipid profile in women with PCOS and may be applicable for reducing PCOS risk factors. © 2017 Center for Food and Biomolecules, National Taiwan Universit

Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome

Background The objectives of study were to investigate the effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome (PCOS). Methods This double-blind randomized controlled clinical trial was conducted on 84 overweight or obese PCOS patients; aged 20�38 years. Subjects in cinnamon (n = 42) and placebo (n = 42) groups were given 3 cinnamon capsules (each one contained 500 mg cinnamon) or placebo daily for 8 weeks. Fasting blood samples, anthropometric measurements and dietary intake data were gathered at the beginning and at the end of the study. Independent t test, paired t test and analysis of covariance were used to analyze of data. Results Cinnamon significantly increased serum total antioxidant capacity (P = 0.005). Malondialdehyde was significantly decreased compared with placebo (P = 0.014). Cinnamon supplementation significantly improved serum level of total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (all P < 0.05). No significant effect was detected on serum triglyceride level. Conclusions Cinnamon supplementation improved antioxidant status and serum lipid profile in women with PCOS and may be applicable for reducing PCOS risk factors. © 2017 Center for Food and Biomolecules, National Taiwan Universit

Premature ovarian failure risk factors in an Iranian population

Alieh Ghassemzadeh1,2, Laya Farzadi1,2, Elaheh Beyhaghi1,21Women&amp;rsquo;s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 2Alzahra University Hospital, Department of Obstetrics and Gynecology, Tabriz University of Medical Sciences, Tabriz, IranBackground: The aim of this study was to determine possible correlates of premature ovarian failure (POF) in an Iranian population.Methods: In a case-control study, 80 patients with POF were compared with 80 controls enrolled from the same setting during 2007&amp;ndash;2008. A food diary was used to assess food consumption habits.Results: Mean age of starting ovarian failure symptoms was 19.3 &amp;plusmn; 5.7 years and mean age of menopause was 22.6 &amp;plusmn; 6.3 years. Familial coincidence was observed in 16 POF patients versus no one in the control group (P &amp;lt; 0.05). POF patients had lower frequency of both eating red meat and fish when compared with controls (P &amp;lt; 0.001). POF and control subjects consumed similar amounts of dairy products, being 5.3 &amp;plusmn; 3.2 times per week in POF and 5.6 &amp;plusmn; 2.1 times in the control groups.Conclusion: In this study, an association between POF and lower red meat or fish consumption was found.Keywords: POF, etiology, case-control, nutrition, premature menopause, premature ovarian dysfunction, primary ovarian insufficienc

Randomized trial of peppermint gel, lanolin ointment, and placebo gel to prevent nipple crack in primiparous breastfeeding women

Background: Sore nipples are common during lactation and remain the major reason for failing to establish successful breastfeeding. To formulate a peppermint gel and to evaluate its effect on the prevention of nipple crack associated with breast-feeding, a randomized double-blinded clinical trial comparing the above formulation with modified lanolin and a neutral ointment was carried out. Material/Methods: Two hundred and sixteen primiparous participants were assigned randomly to three groups. Each group applied only one of the above three preparations on both breasts for 14 days. Each group consisted of 72 primiparous mothers and was seen for a maximum of four follow-up visits within 14 days and a final visit at week 6. The rate of nipple and areola crack and pain was evaluated. Results: The study groups were comparable in mean age and route of delivery. Nipple crack were less in mothers who received peppermint gel than in those who received lanolin ointment or placebo (?2=16.8, df=6, P=0.01). Relative risk of nipple crack in the lanolin group (RR: 2.41, 95%CI: 1.20–3.01) was higher than in the peppermint group (RR: 1.85, 95%CI: 1.64–3.10). Conclusions: Prophylactic peppermint gel in breastfeeding lactating women is associated with fewer nipple cracks and is more effective than lanolin and placebo. It could be recommended for preventing of nipple crack along with teaching better breastfeeding technique at the initiation of breastfeedin