Participants’ Experiences of EMDR Training.

This research projects spans a 6-year period surveying 485 participants’ experiences of eye movement desensitization and reprocessing (EMDR) training in the United Kingdom and Ireland between the periods of 2005 and 2011. This research used a mixed research methodology exploring EMDR training participants’ application of EMDR within their current clinical practice. The rationale was to explore potential differences between EMDR-accredited and EMDR-nonaccredited clinicians in relation to retrospective reports of treatment. Results indicate that EMDR-accredited clinicians report better treatment outcomes. An argument is presented that EMDR has progressed from a convergent technique to a divergent psychotherapeutic approach. Consequently, the research explored whether current EMDR training is “fit for purpose.” A comprehensive model for EMDR training is outlined, proposing the importance of developing more EMDR training in academic institutions

Hurricane Rated Pet Door Final Design Report

Our Senior Design group has been commissioned by a major pet door distributor, Pet Doors USA, to create a working prototype of a hurricane rated pet door. The main goal of this project is to meet specifications set out for us by our sponsor which include; making the door accessible to a 25-100 lb dog and meeting DP50 Hurricane Code. The final design is a rotating door that utilizes a worm gear and worm screw that turn a shaft to which the door is attached. A polycarbonate front panel is used due to its strength and impact resistance. The automation is accomplished with the use of RFID tags and sensors. The pet wears an RFID tag and when it comes in range of the sensors it signals the door to open. The final tests to be performed on the door included the water infiltration test, the final impact test, and the pressure/deflection test. For the water infiltration test, cobalt chloride paper was used to determine whether any moisture came through the door after spraying it with a hose. During the test, water began to infiltrate the corner of the door where the individual pieces of the weather-stripping meet and allow for a small crack. The pressure test setup was to place the door horizontally and place a box full of sand directly above the door. This test was successful with no permanent deflection or perceived dam- age to the pet door. For the impact test, a rack of weights with a 2x4 attached to it was dropped onto the door panel. The panel withstood the impact with no signs of cracks, indentions, or any other damage. When the door was tested for functionality, it was discovered that the power generated by the controller is insufficient to open the door. However, by attaching the motor to an external power source, the door was able to open easily. Thus, both the mechanical and electrical assemblies work independently but in order to merge them there needs to be more time and effort devoted to this project. Aside from this, the project can be considered a success in that all failures have been identified and a minimal amount of additional work is needed to create a working prototype that can pass all the required tests

Roundtable discussion: Men who travel to abuse children: The issue of transnational child sexual abuse

Men travelling within and across national borders to conduct sexual offences against children is a significant public protection concern. What challenges does each sector face with regard to transnational child sexual abuse? How can these challenges be tackled effectively? We invite you to join a forum for knowledge exchange between different sectors, including police, government, offender management, child protection, cultural studies, and tourism

The Effect of Race, Sex, and Insurance Status on Time-to-Listing Decisions for Liver Transplantation

Fair allocation of organs to candidates listed for transplantation is fundamental to organ-donation policies. Processes leading to listing decisions are neither regulated nor understood. We explored whether patient characteristics affected timeliness of listing using population-based data on 144,507 adults hospitalized with liver-related disease in Pennsylvania. We linked hospitalizations to other secondary data and found 3,071 listed for transplants, 1,537 received transplants, and 57,020 died. Among candidates, 61% (n = 1,879) and 85.5% (n = 2,626) were listed within 1 and 3 years of diagnosis; 26.7% (n = 1,130) and 95% (n = 1,468) of recipients were transplanted within 1 and 3 years of listing. Using competing-risks models, we found few overall differences by sex, but both black patients and those insured by Medicare and Medicaid (combined) waited longer before being listed. Patients with combined Medicare and Medicaid insurance, as well as those with Medicaid alone, were also more likely to die without ever being listed. Once listed, the time to transplant was slightly longer for women, but it did not differ by race/ethnicity or insurance. The early time period from diagnosis to listing for liver transplantation reveals unwanted variation related to demographics that jeopardizes overall fairness of organ allocation and needs to be further explored

Muskellunge and Northern Pike Ecology and Management: Important Issues and Research Needs

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141909/1/fsh0258.pd

Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes

AIM: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no studies have interrogated this epigenetic modification in early disease. Following recent investigations of T- and B-lymphocytes in established disease, we now characterize in these cell populations genome-wide DNA methylation in treatment-naive patients with early RA. PATIENTS & METHODS: HumanMethylation450 BeadChips were used to examine genome-wide DNA methylation in lymphocyte populations from 23 early RA patients and 11 healthy individuals. RESULTS: Approximately 2000 CpGs in each cell type were differentially methylated in early RA. Clustering analysis identified a novel methylation signature in each cell type (150 sites in T-lymphocytes, 113 sites in B-lymphocytes) that clustered all patients separately from controls. A subset of sites differentially methylated in early RA displayed similar changes in established disease. CONCLUSION: Treatment-naive early RA patients display novel disease-specific DNA methylation aberrations, supporting a potential role for these changes in the development of RA

Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals

Multiple reports now describe changes to the DNA methylome in rheumatoid arthritis and in many cases have analyzed methylation in mixed cell populations from whole blood. However, these approaches may preclude the identification of cell type-specific methylation, which may subsequently bias identification of disease-specific changes. To address this possibility, we conducted genome-wide DNA methylation profiling using HumanMethylation450 BeadChips to identify differences within matched pairs of T-lymphocytes and B-lymphocytes isolated from the peripheral blood of 10 healthy females. Array data were processed and differential methylation identified using NIMBL software. Validation of array data was performed by bisulfite Pyrosequencing. Genome-wide DNA methylation was initially determined by analysis of LINE-1 sequences and was higher in B-lymphocytes than matched T-lymphocytes (69.8 vs. 65.2%, p ≤ 0.01). Pairwise analysis identified 679 CpGs, representing 250 genes, which were differentially methylated between T-lymphocytes and B-lymphocytes. The majority of sites (76.6%) were hypermethylated in B-lymphocytes. Pyrosequencing of selected candidates confirmed the array data in all cases. Hierarchical clustering revealed perfect segregation of samples into two distinct clusters based on cell type. Differentially methylated genes showed enrichment for biological functions/pathways associated with leukocytes and T-lymphocytes. Our work for the first time shows that T-lymphocytes and B-lymphocytes possess intrinsic differences in DNA methylation within a restricted set of functionally-related genes. These data provide a foundation for investigating DNA methylation in diseases in which these cell types play important and distinct roles