High-frequency data observations from space shuttle main engine low pressure fuel turbopump discharge duct flex joint tripod failure investigation

Observations made by Marshall Space Flight Center (MSFC) engineers during their participation in the Space Shuttle Main Engine (SSME) low pressure fuel turbopump discharge duct flex joint tripod failure investigation are summarized. New signal processing techniques used by the Component Assessment Branch and the Induced Environments Branch during the failure investigation are described in detail. Moreover, nonlinear correlations between frequently encountered anomalous frequencies found in SSME dynamic data are discussed. A recommendation is made to continue low pressure fuel (LPF) duct testing through laboratory flow simulations and MSFC-managed technology test bed SSME testing

A Conjoint Analysis of Site Selection for the U.S. Broiler Industry: Impications for Louisiana (Bulletin #882)

The purpose of this study is to analyze broiler industry executives’ decisions on where to locate a broiler complex in the United States. The specific objectives are to identify factors affecting site locations of broiler complexes in the United States and to measure the effects and relative importance of these factors on the broiler complex location decision.https://digitalcommons.lsu.edu/agcenter_bulletins/1013/thumbnail.jp

Research on Protection of Minors: A literature Review and Interconnected Frameworks Implications for VSP Regulation and Beyond

Ofcom commissioned the Institute for Connected Communities at the University of East London (UEL) to conduct this research in order to help inform VSP guidance. The particular areas of interest identified by Ofcom were:Which risks of harm are most prevalent among minors on VSPs (considering both quantitative and qualitative evidence)? How do these harms manifest on VSPs? Are different VSP characteristics relevant to protecting users from harms

Facilitating Building Information Modelling (BIM) using Integrated Project Delivery (IPD): A UK perspective

The Construction industry is a major player in the UK economy and is in need of continuous improvement. In an attempt to do so, in 2011 the UK government made Building Information Modelling (BIM) level 2 a mandate for all public projects by 2016. Integrated Project Delivery (IPD) is a project delivery approach closely attributed to BIM. However, it does not seem to have received proportionate level of attention and uptake in the UK

Modeling the Redshift Evolution of the Normal Galaxy X-ray Luminosity Function

Emission from X-ray binaries (XRBs) is a major component of the total X-ray luminosity of normal galaxies, so X-ray studies of high redshift galaxies allow us to probe the formation and evolution of X-ray binaries on very long timescales. In this paper, we present results from large-scale population synthesis models of binary populations in galaxies from z = 0 to 20. We use as input into our modeling the Millennium II Cosmological Simulation and the updated semi-analytic galaxy catalog by Guo et al. (2011) to self-consistently account for the star formation history (SFH) and metallicity evolution of each galaxy. We run a grid of 192 models, varying all the parameters known from previous studies to affect the evolution of XRBs. We use our models and observationally derived prescriptions for hot gas emission to create theoretical galaxy X-ray luminosity functions (XLFs) for several redshift bins. Models with low CE efficiencies, a 50% twins mass ratio distribution, a steeper IMF exponent, and high stellar wind mass loss rates best match observational results from Tzanavaris & Georgantopoulos (2008), though they significantly underproduce bright early-type and very bright (Lx > 10d41) late-type galaxies. These discrepancies are likely caused by uncertainties in hot gas emission and SFHs, AGN contamination, and a lack of dynamically formed Low-mass XRBs. In our highest likelihood models, we find that hot gas emission dominates the emission for most bright galaxies. We also find that the evolution of the normal galaxy X-ray luminosity density out to z = 4 is driven largely by XRBs in galaxies with X-ray luminosities between 10d40 and 10d41 erg/s.Comment: Accepted into ApJ, 17 pages, 3 tables, 7 figures. Text updated to address referee's comment

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease

Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease. Loss of function of the nuclear receptor REV-ERB is associated with reduced cognitive function in mouse models. The effect of enhanced REV-ERB activity on cognitive function has not been examined. In this study, we tested the hypothesis that enhanced REV-ERB function may enhance cognitive function in a model of Alzheimer’s disease. We utilized the REV-ERB agonist SR9009 to pharmacologically activate the activity of REV-ERB in the SAMP8 mouse model of Alzheimer’s disease. SR9009 reversed cognitive dysfunction of an aged SAMP8 mouse in several behavioral assays including novel object recognition, T-maze foot shock avoidance, and lever press operant conditioning task assessments. SR9009 treatment reduced amyloid-β 1–40 and 1–42 levels in the cortex, which is consistent with improved cognitive function. Furthermore, SR9009 treatment led to increased hippocampal PSD-95, cortical synaptophysin expression and the number of synapses suggesting improvement in synaptic function. We conclude that REV-ERB is a potential target for treatment of Alzheimer’s disease.</div

Early Advanced LIGO binary neutron-star sky localization and parameter estimation

2015 will see the first observations of Advanced LIGO and the start of the gravitational-wave (GW) advanced-detector era. One of the most promising sources for ground-based GW detectors are binary neutron-star (BNS) coalescences. In order to use any detections for astrophysics, we must understand the capabilities of our parameter-estimation analysis. By simulating the GWs from an astrophysically motivated population of BNSs, we examine the accuracy of parameter inferences in the early advanced-detector era. We find that sky location, which is important for electromagnetic follow-up, can be determined rapidly (~5 s), but that sky areas may be hundreds of square degrees. The degeneracy between component mass and spin means there is significant uncertainty for measurements of the individual masses and spins; however, the chirp mass is well measured (typically better than 0.1%).Comment: 4 pages, 2 figures. Published in the proceedings of Amaldi 1

Binary evolution with LOFT

This is a White Paper in support of the mission concept of the Large Observatory for X-ray Timing (LOFT), proposed as a medium-sized ESA mission. We discuss the potential of LOFT for the study of very faint X-ray binaries, orbital period distribution of black hole X-ray binaries and neutron star spin up. For a summary, we refer to the paper.Comment: White Paper in Support of the Mission Concept of the Large Observatory for X-ray Timing. (v2 few typos corrected