Low-temperature thermochronology of francolite: Insights into timing of Dead Sea Transform motion

Cambrian siliciclastic sequences along the Dead Sea Transform (DST) margin in southern Israel and southern Jordan host both detrital fluorapatite [D‐apatite] and U‐rich authigenic carbonate‐fluorapatite (francolite) [A‐apatite]. D‐apatite and underlying Neoproterozoic basement apatite yield fission track (FT) data reflecting Paleozoic‐Mesozoic sedimentary cycles and epeirogenic events, and dispersed (U‐Th‐Sm)/He (AHe) ages. A‐apatite, which may partially or completely replace D‐apatite, yields an early Miocene FT age suggesting formation by fracturing, hydrothermal fluid ascent and intra‐strata recrystallisation, linked to early DST motion. The DST, separating the African and Arabian plates, records ~105 km of sinistral strike‐slip displacement, but became more transtensional post‐5 Ma. Helium diffusion measurements on A‐apatite are consistent with thermally activated volume diffusion, indicating Tc ~52‐56±10°C (cooling rate 10°C/Myr). A‐apatite AHe data record Pliocene cooling (~35‐40°C) during the transtensional phase of movement. This suggests that timing of important milestones in DST motion can be discerned using A‐apatite low‐temperature thermochronology data alone

Low-temperature thermochronology of francolite: Insights into timing of Dead Sea Transform motion

Cambrian siliciclastic sequences along the Dead Sea Transform (DST) margin in southern Israel and southern Jordan host both detrital fluorapatite [D‐apatite] and U‐rich authigenic carbonate‐fluorapatite (francolite) [A‐apatite]. D‐apatite and underlying Neoproterozoic basement apatite yield fission track (FT) data reflecting Paleozoic‐Mesozoic sedimentary cycles and epeirogenic events, and dispersed (U‐Th‐Sm)/He (AHe) ages. A‐apatite, which may partially or completely replace D‐apatite, yields an early Miocene FT age suggesting formation by fracturing, hydrothermal fluid ascent and intra‐strata recrystallisation, linked to early DST motion. The DST, separating the African and Arabian plates, records ~105 km of sinistral strike‐slip displacement, but became more transtensional post‐5 Ma. Helium diffusion measurements on A‐apatite are consistent with thermally activated volume diffusion, indicating Tc ~52‐56±10°C (cooling rate 10°C/Myr). A‐apatite AHe data record Pliocene cooling (~35‐40°C) during the transtensional phase of movement. This suggests that timing of important milestones in DST motion can be discerned using A‐apatite low‐temperature thermochronology data alone

The science process for selecting the landing site for the 2020 Mars rover

The process of identifying the landing site for NASA's Mars 2020 rover began in 2013 by defining threshold mission science criteria related to seeking signs of ancient habitable conditions, searching for biosignatures of past microbial life, assembling a returnable cache of samples for possible future return to Earth, and collecting data for planning eventual human missions to the surface of Mars. Mission engineering constraints on elevation and latitude were used to identify candidate landing sites that addressed the scientific objectives of the mission. However, for the first time these constraints did not have a major influence on the viability of candidate sites and, with the new entry, descent, and landing capabilities included in the baseline mission, the vast majority of sites were evaluated and down-selected on the basis of science merit. More than 30 candidate sites with likely acceptable surface and atmospheric conditions were considered at a series of open workshops in the years leading up to the launch. During that period, iteration between engineering constraints and the evolving relative science potential of candidate sites led to the identification of three final candidate sites: Jezero crater (18.4386°N, 77.5031°E), northeast (NE) Syrtis (17.8899°N,77.1599°E) and Columbia Hills (14.5478°S, 175.6255°E). The final landing site will be selected by NASA's Associate Administrator for the Science Mission Directorate. This paper serves as a record of landing site selection activities related primarily to science, an inventory of the number and variety of sites proposed, and a summary of the science potential of the highest-ranking sites

A rusty record of weathering and groundwater movement in the hyperarid Central Andes

The Atacama Desert, on the western margin of the Central Andes, hosts some of the world's largest porphyry copper deposits (PCDs). Despite a hyperarid climate, many of these PCDs have undergone secondary “supergene” enrichment, whereby copper has been concentrated via groundwater-driven leaching and reprecipitation, yielding supergene profiles containing valuable records of weathering and landscape evolution. We combine hematite (U-Th-Sm)/He geochronology and oxygen isotope analysis to compare the weathering histories of two Andean PCDs and test the relative importance of climate and tectonics in controlling both enrichment and water table movement. At Cerro Colorado, in the Precordillera, hematite precipitation records prolonged weathering from ∼31 to ∼2 Ma, tracking water table descent following aridity-induced canyon incision from the late Miocene onward. By contrast, hematite at Spence, within the Central Depression, is mostly younger than ∼10.5 Ma, suggesting exhumation ended much later. A heavy oxygen isotopic signature for Spence hematite suggests that upwelling formation water has been an important source of groundwater, accounting for a high modern water table despite persistent hyperaridity, whereas isotopically light hematite at Cerro Colorado formed in the presence of meteoric water. Compared with published paleo-environmental and sedimentological records, our data show that weathering can persist beneath appreciable post-exhumation cover, under hyperarid conditions unconducive to enrichment. The susceptibility of each deposit to aridity-induced water table descent, canyon incision and deep weathering has been controlled by recharge characteristics and morphotectonic setting. Erosional exhumation, rather than aridity-induced water table decay, appears to be more important for the development of supergene enrichment

Catalytic enantioselective nucleophilic desymmetrization of phosphonate esters

Molecules that contain a stereogenic phosphorus atom are crucial to medicine, agrochemistry and catalysis. While methods are available for the selective construction of various chiral organophosphorus compounds, catalytic enantioselective approaches for their synthesis are far less common. Given the vastness of possible substituent combinations around a phosphorus atom, protocols for their preparation should also be divergent, providing facile access not only to one but to many classes of phosphorus compounds. Here we introduce a catalytic and enantioselective strategy for the preparation of an enantioenriched phosphorus(V) centre that can be diversified enantiospecifically to a wide range of biologically relevant phosphorus(V) compounds. The process, which involves an enantioselective nucleophilic substitution catalysed by a superbasic bifunctional iminophosphorane catalyst, can accommodate a wide range of carbon substituents at phosphorus. The resulting stable, yet versatile, synthetic intermediates can be combined with a multitude of medicinally relevant O-, N- and S-based nucleophiles

The science process for selecting the landing site for the 2020 Mars rover

The process of identifying the landing site for NASA's Mars 2020 rover began in 2013 by defining threshold mission science criteria related to seeking signs of ancient habitable conditions, searching for biosignatures of past microbial life, assembling a returnable cache of samples for possible future return to Earth, and collecting data for planning eventual human missions to the surface of Mars. Mission engineering constraints on elevation and latitude were used to identify candidate landing sites that addressed the scientific objectives of the mission. However, for the first time these constraints did not have a major influence on the viability of candidate sites and, with the new entry, descent, and landing capabilities included in the baseline mission, the vast majority of sites were evaluated and down-selected on the basis of science merit. More than 30 candidate sites with likely acceptable surface and atmospheric conditions were considered at a series of open workshops in the years leading up to the launch. During that period, iteration between engineering constraints and the evolving relative science potential of candidate sites led to the identification of three final candidate sites: Jezero crater (18.4386°N, 77.5031°E), northeast (NE) Syrtis (17.8899°N,77.1599°E) and Columbia Hills (14.5478°S, 175.6255°E). The final landing site will be selected by NASA's Associate Administrator for the Science Mission Directorate. This paper serves as a record of landing site selection activities related primarily to science, an inventory of the number and variety of sites proposed, and a summary of the science potential of the highest-ranking sites

The Mass Analyzer for Real-time Investigation of Neutrals at Europa (MARINE)

Presented herein is the progress on developing a new mass analyzer for analysis of the exospheres of planets, moons, and primitive bodies, such as found at Europa or Enceladus. Europa, one of Jupiter's four Galilean moons, may have a subsurface ocean plausibly containing the key ingredients for life as well as sources of chemical energy. Clues to the composition and chemical state of Europa's ocean can be found both on Europa's icy surface and in its tenuous atmosphere. Given the high scientific priority of assessing the habitability of Europa's ocean, the Europa Clipper notional payload includes a Neutral Mass Spectrometer whose purpose is to characterize the composition of ejected surface products during a series of flyby investigations. The Mass Analyzer for Real-time Investigation of Neutrals at Europa (MARINE) is capable of measuring the abundances of neutral particle species in Europa's exosphere including H_2O, O_2, CO_2, and SO_2, and determining their number density profiles at per-second sampling rates as a function of altitude above Europa's surface. MARINE will either detect tracers of potential subsurface biological activity in Europa's exosphere, or place upper limits on their surface abundances. It exceeds all requirements for the proposed investigations with margins ranging from 100 to 1000%, while remaining fully compatible with spacecraft accommodation constraints for mass, power, data volume, and field-of-view

Management of Massive Arterial Hemorrhage After Pancreatobiliary Surgery: Does Embolotherapy Contribute to Successful Outcome?

Massive arterial hemorrhage is, although unusual, a life-threatening complication of major pancreatobiliary surgery. Records of 351 patients who underwent major surgery for malignant pancreatobiliary disease were reviewed in this series. Thirteen patients (3.7%) experienced massive hemorrhage after surgery. Complete hemostasis by transcatheter arterial embolization (TAE) or re-laparotomy was achieved in five patients and one patient, respectively. However, 7 of 13 cases ended in fatality, which is a 54% mortality rate. Among six survivors, one underwent selective TAE for a pseudoaneurysm of the right hepatic artery (RHA). Three patients underwent TAE proximal to the proper hepatic artery (PHA): hepatic inflow was maintained by successful TAE of the gastroduodenal artery in two and via a well-developed subphrenic artery in one. One patient had TAE of the celiac axis for a pseudoaneurysm of the splenic artery (SPA), and hepatic inflow was maintained by the arcades around the pancreatic head. One patient who experienced a pseudoaneurysm of the RHA after left hemihepatectomy successfully underwent re-laparotomy, ligation of RHA, and creation of an ileocolic arterioportal shunt. In contrast, four of seven patients with fatal outcomes experienced hepatic infarction following TAE proximal to the PHA or injury of the common hepatic artery during angiography. One patient who underwent a major hepatectomy for hilar bile duct cancer had a recurrent hemorrhage after TAE of the gastroduodenal artery and experienced hepatic failure. In the two patients with a pseudoaneurysm of the SPA or the superior mesenteric artery, an emergency re-laparotomy was required to obtain hemostasis because of worsening clinical status. Selective TAE distal to PHA or in the SPA is usually successful. TAE proximal to PHA must be restricted to cases where collateral hepatic blood flow exists. Otherwise or for a pseudoaneurysm of the superior mesenteric artery, endovascular stenting, temporary creation of an ileocolic arterioportal shunt, or vascular reconstruction by re-laparotomy is an alternative