Pregnancy outcomes of women whom spouse fathered children after tyrosine kinase inhibitor therapy for chronic myeloid leukemia : A systematic review

The introduction of tyrosine kinase inhibitors (TKIs) has revolutionized the therapy of chronic myeloid leukemia (CML). Although the efficacy of TKIs is beyond dispute, conception-related safety issues are still waiting to be explored, particularly in males. This systematic review aimed to summarize all available evidence on pregnancy outcomes of female spouses of male CML patients who fathered children after TKI treatment for CML.We performed a systematic search in seven electronic databases for studies that reported on male CML patients who did or did not discontinue TKI treatment before conceiving, and the pregnancy outcomes of their female spouse are available. The search centered on the TKI era (from 2001 onward) without any other language or study design restrictions.Out of a total of 38 potentially eligible papers, 27 non-overlapping study cohorts were analyzed. All were descriptive studies (case or case series studies). Altogether, 428 pregnancies from 374 fathers conceived without treatment discontinuation, 400 of which (93.5%) ended up in a live birth. A total of ten offspring with a malformation (2.5%) were reported: six with imatinib (of 313 live births, 1.9%), two with nilotinib (of 26 live births, 7.7%), one with dasatinib (of 43 live births, 2.3%), and none with bosutinib (of 12 live births). Data on CML status were scarcely reported. Only nine pregnancies (from nine males) and no malformation were reported in males who discontinued TKI treatment before conception.Malformations affected, on average 2.5% of live births from fathers who did not discontinue TKI treatment before conception, which is comparable with the rate of malformations in the general population. Large-scale studies with representative samples are awaited to confirm our results

Szénhidrogének és alkoholok reakciójának katalitikus és felületkémiai vizsgálata = Catalytic and surface science studies related to the reactions of hydrocarbons and alcohols

Tanulmányoztuk a benzol, metanol, dimetil és dietil éter aromatizációját és a metilezését a ZSM-5 zeolitra rávitt Mo2C, Ga2O3 és ZnO-on. Mindhárom anyag hatásosan katalizálta a metanol aromatizációját, és a Mo2C/ZSM-5 elősegítette a benzol metilezését is. Spektroszkópiai módszerekkel feltártuk a zeolit és a Mo2C szerepét. Kísérleteink másik részében a hidrogén előállítására koncentráltunk. Elsődleges célunk a drága platina fémeket helyettesítő olcsó és stabilis katalizátor szintézise volt. Erre a célra legmegfelelőbbnek ismét a Mo2C bizonyult. Amennyiben a Mo2C-t nagy felületű többfalú szén nanocsőre vagy Norit szénre vittük rá, az alkoholok átalakításának iránya megváltozott: az etanol és metanol aromatizációja helyett a hidrogén képződése került előtérbe. A hidrogén előállításával kapcsolatos kutatási programunk talán egyik legfontosabb eredménye, hogy a Mo2C/carbon katalizátoron a HCOOH bomlásának katalízisével sikerült tiszta, CO mentes hidrogént előállítanunk alacsony hőmérsékleten. Párhuzamosan folyó elektron-spektroszkópiai módszerekkel feltártuk a reakciók primér lépéseit és a felületen képződő gyökök átalakulásának irányát. Elektron- foton- és ion spektroszkópiával (AES, XPS, LEIS, RAIRS), valamint STM-el tanulmányoztuk a kétfémes nanoszerkezetek képződését és fizikai-kémiai sajátságait egykristály titán-dioxid felületen. Eredményeinket 20 nemzetközi folyóiratban megjelent dolgozatban közöltük és azokról különböző nemzetközi konferenciákon 35 előadást tartottunk. | The adsorption and reaction pathways of methanol, dimethyl and diethyl ethers have been investigated on pure and Mo2C containing ZSM-5. ZSM-5 effectively catalyzed the reaction of all the three compounds above 473 K to yield various olefins and aromatics. Adding Mo2C to the zeolites greatly promoted the formation of aromatics very likely by catalyzing the aromatization of olefins formed in the reaction. Addition of benzene to dimethyl ether markedly increased the formation of toluene, xylene and C9 aromatics on ZSM-5. The enhancement was further increased by ZnO and Mo2C promoters. Extensive research has been carried out recently to develop a procedure for the production of clean hydrogen for fuel cells. Efforts were also made to replace the expensive Pt metals with more effective, stable, and less expensive catalysts. We found that Mo2C when it is prepared on different carbon supports is an effective catalyst for the decomposition of alcohols and ether to give hydrogen. In the case of reforming of HCOOH we achieved to produce H2 free of CO. The adsorption and reaction pathways of above compounds on Mo2C/Mo(100) have been studied by several electron spectroscopic methods. The results helped to establish the mechanism of the catalytic reactions. Detailed spectroscopic experiments were performed concerning the interaction of Au with Rh on TiO2(100). We gave account on our results in 20 papers published in international journals, and presented 35 lectures at various Conferences

Ultrafiltration is better than diuretic therapy for volume-overloaded acute heart failure patients: a meta-analysis

Studies on the effectiveness of ultrafiltration (UF) in patients hospitalized with acute decompensated heart failure (ADHF) have led to heterogeneous study outcomes. This meta-analysis aimed to assess the impact of UF therapy in ADHF patients. We searched the medical literature to identify well-designed studies comparing UF with the usual diuretic therapy in this setting. Systematic evaluation of 8 randomized controlled trials enrolling 801 participants showed greater fluid removal (difference in means 1372.5 mL, 95% CI 849.6 to 1895.4 mL; p < 0.001), weight loss (difference in means 1.592 kg, 95% CI 1.039 to 2.144 kg; p < 0.001) and lower incidences of worsening heart failure (OR 0.63, 95% CI 0.43 to 0.94, p = 0.022) and rehospitalization for heart failure (OR 0.54, 95% CI 0.36 to 0.82, p = 0.003) without a difference in renal impairment (OR 1.386, 95% CI 0.870 to 2.209; p = 0.169) or all-cause mortality (OR 1.13, 95% CI 0.75 to 1.71, p = 0.546). UF increases fluid removal and weight loss and reduces rehospitalization and the risk of worsening heart failure in congestive patients, suggesting ultrafiltration as a safe and effective treatment option for volume-overloaded heart failure patients

DFT study of methanol adsorption and dissociation on β-Mo2C(0 0 1)

We have studied the adsorption and dissociation of methanol on β-Mo2C(0 0 1) model surface using density functional theory calculations. We modeled the bulk and the Mo-terminated carbide surface using a four layer slab. Methanol is adsorbed with the OH group pointing towards the surface and the formation of the methoxy specie is energetically favorable after H abstraction. The surface outward dipole moment and adsorption heat computed are in agreement with previous experimental data in chemically analogous systems. The bonding analysis using the crystal orbital overlap population (COOP) curves shows a Mo-Mo weakening upon adsorption and a strong H-Mo interaction after dissociation. © 2008 Elsevier B.V. All rights reserved.Fil: Pistonesi, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Juan, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Farkas, Arnold Péter. University of Szeged; HungríaFil: Solymosi, F.. University of Szeged; Hungrí

Effects of potassium on the adsorption of methanol on β-Mo2C(001) surface

We have studied the effect of K on the adsorption of methanol on the β-Mo2C(001) surface and compared our experimental data with theoretical calculations. We have also performed high resolution electron energy loss spectroscopy (HREELS) (LK, ELS3000). For calculations we used the density functional theory under the VASP implementation. The most favorable sites for methanol adsorption are on top of a Mo atom in the clean surface and on top of a K atom in the pre-dosed surface. The changes in the work function fit our model as the surface withdraws charge from the adsorbate. The changes in the computed vibrational frequencies also agree with the HREELS results at very low coverage. The C-O bond distance increases while the O-H bond decreases making a C-O bond breakage a possibility on K covered surfaces.Fil: Pistonesi, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Juan, Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Física del Sur. Universidad Nacional del Sur. Departamento de Física. Instituto de Física del Sur; ArgentinaFil: Farkas, Arnold Péter. University of Szeged; HungríaFil: Solymosi, F.. University of Szeged; Hungrí