Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Maximal operators, Riesz transforms and Littlewood-Paley functions associated with Bessel operators on BMO

In this paper we study boundedness properties of certain harmonic analysis operators (maximal operators for heat and Poisson semigroups, Riesz transforms and Littlewood– Paley g-functions) associated with Bessel operators, on the space BMOo(R) that consists of the odd functions with bounded mean oscillation on R.Fil: Betancor, J. J.. Universidad de La Laguna; EspañaFil: Chicco Ruiz, Anibal Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Matemática Aplicada del Litoral. Universidad Nacional del Litoral. Instituto de Matemática Aplicada del Litoral; ArgentinaFil: Fariña, J. C.. Universidad de La Laguna; EspañaFil: Rodriguez Mesa, L.. Universidad de La Laguna; Españ

Hornodermoporus martius secretome

Here we present the secreted proteins by the fungus Hornodermoporus martius in a liquid medium, focusing on the proteolytic enzymes for fibrin degradation.Fil: Acosta, Gabriela Alejandra. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chelaliche, Anibal Sebastian. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fonseca, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; ArgentinaFil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; ArgentinaFil: Zapata, Pedro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentin

Schizophyllum commune secretome

Here we present the secreted proteins by the fungus Schizophyllum commune in a liquid medium, focusing on the proteolytic enzymes for fibrin degradation.Fil: Acosta, Gabriela Alejandra. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Chelaliche, Anibal Sebastian. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fonseca, Maria Isabel. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fariña, Julia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Planta Piloto de Procesos Industriales Microbiológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zapata, Pedro Dario. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Departamento de Bioquímica Clínica. Laboratorio de Biotecnología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Dificuldades para obter informações da população de mulheres sobre aborto ilegal Difficulties encountered in gathering information on illegal abortion of women population

Qualquer tentativa de se investigar a prática de abortos ilegais deve lidar com o problema de estar perguntando às mulheres acerca de um tema delicado, sensível, com implicações múltiplas, o que leva a dificuldades para se obter informações verazes. O estudo realizado enfoca principalmente aspectos metodológicos de uma pesquisa realizada junto a uma população de mulheres de 15 a 49 anos de idade, com o objetivo de verificar a freqüência e as condições em que era feito o aborto provocado em uma região do Estado de São Paulo (Brasil). Foram entrevistadas, em seus domicílios, 1.955 mulheres. Utilizou-se um questionário estruturado e pré-testado. A maioria das entrevistadas declarou nunca ter abortado nem pensado em fazê-lo, enquanto 4% referiram alguma vez ter feito aborto; 16,7% disseram que, pelo menos uma vez, tomaram chá/remédio para menstruar. Entre as que acreditaram estar grávidas na ocasião, a maioria informou nunca ter abortado, apesar de terem menstruado quando ingeriram chá/remédio. Os resultados permitiram concluir que as mulheres tendem a omitir a informação sobre a prática de aborto quando perguntadas diretamente sobre isso. Especialmente aquelas que o induzem por ingestão de substâncias parecem não reconhecer esse ato como sendo uma forma de interromper a gestação.<br>Any attempt to study the practice of illegal abortion faces the problem of asking women about a delicate, sensitive issue that has many implications. This may make it difficult to obtain truthful information on the subject. Results related to methodological aspects are emphasized and their possible association with variables included in a cross-sectional study carried out among 1.955 women, of 15 to 49 years of age is analysed. The frequency and conditions under which induced abortion was performed in a region of S. Paulo State are investigated. The women were interviewed at home using a pre-tested, structured questionnaire. Most of the women interviewed declared they had never had an abortion nor had they thought of having one, and four percent referred to having had an induced abortion. However, another 16.7 percent said that they had taken tea or medicine at least once to bring on their menses. In this group, most of the women who thought they were pregnant at that time said they had had never an abortion, in spite of having bled after drinking tea or medicine. The results lead to the conclusion that women tend no omit information on the practice of abortion when questioned directly. This is especially true of those who use oral means to bring on their menses and who seemed not to consider this a way of inducing an abortion

Compendio de resultados de investigación. Proyecto IPTA - CONACYT 14 - INV - 447: Validación y difusión de prácticas agronómicas sustentables para el mejoramiento de la tecnología de producción de frutilla en la zona frutillera de la cuenca del lago Ypacaraí

El Proyecto tiene como propósito mejorar la productividad del cultivo de la frutilla a través de la adaptación de prácticas agronómicas sustentables en finca de productores de la zona frutillera mediante la generación de un paquete tecnológico adaptado a su realidad de producción.CONACYT – Consejo Nacional de Ciencia y TecnologíaPROCIENCI