Plan de intervención: cuidado integral a pacientes adultos con enfermedades no transmisibles atendidos en el puesto de Salud Los Ángeles – Moquegua, 2022

Por tanto, el propósito de la elaboración del presente trabajo académico titulado “PLAN DE INTERVENCIÓN: CUIDADO INTEGRAL A PACIENTES ADULTOS CON ENFERMEDADES NO TRANSMISIBLES ATENDIDOS EN EL PUESTO DE SALUD LOS ÁNGELES – MOQUEGUA, 2022” responde al elevado número de casos de pacientes adultos en el centro poblado los Ángeles que tiene por finalidad implementar un plan de intervención de enfermería para las personas adultas del Centro Poblado de Los Ángeles de la ciudad de Moquegua para tener como producto final mejorar la salud de este curso de vida analizando en forma consiente cada uno de los factores como la obesidad y la poca actividad física de los seres humanos que nos permita dar un cuidado integral con enfoque humanístico

Efecto de la enseñanza de ajedrez en las habilidades matemáticas, de atención y concentración en niños en edad escolar de la amazonía peruana

The study aimed to analyze the influence of learning chess on mathematical, attention, and concentration abilities in school-aged children of two Schools in Peruvian Amazon. First-grade secondary school students were selected from two schools in Puerto Maldonado city, public and private. The design of the study was quasi-experimental, pretest-posttest evaluations and a control group. Each group had between 18-30 students, and the experimental group was given chess classes twice a week for three months. To analyze the effect of the intervention a Generalized Linear Model was used. In the two abilities evaluated, the posttest results of the experimental group were higher than the control group. A significant effect of the application of sports chess was found in the development of abilities in mathematical reasoning, attention, and concentration (P < 0.001). In the public school, the effect of the program on mathematical reasoning was higher in boys than in girls (P < 0.05). Our results provide relevant information for schools to develop strategies to promote chess as a teaching strategy. We concluded that the implementation of a chess program influences the development of the intellectual abilities in school-aged children of Peruvian Amazon.El presente estudio analiza la influencia del aprendizaje de ajedrez sobre las habilidades en razonamiento matemático, atención y concentración en niños en edad escolar de la Amazonia peruana. Se seleccionaron estudiantes de primer grado de secundaria de dos instituciones educativas de la ciudad de Puerto Maldonado, pública y privada. El diseño del estudio fue cuasiexperimental, con evaluaciones pretest-postest y un grupo control. Cada grupo tenía entre 18 a 30 estudiantes y al grupo experimental se le brindó clases de ajedrez dos veces por semana durante tres meses. Para analizar el efecto de la intervención se utilizó un Modelo Linear Generalizado. En las dos habilidades evaluadas los resultados del postest del grupo experimental fueron superiores al grupo control. Se encontró un efecto significativo de la aplicación del ajedrez deportivo en el desarrollo de habilidades en razonamiento matemático y atención y concentración (P<0.001). En la institución pública el efecto del programa en razonamiento lógico matemático fue superior en los varones que en las mujeres (P<0.05). Nuestros resultados aportan información relevante para que las instituciones educativas puedan desarrollar estrategias para promover el ajedrez como una herramienta y estrategia pedagógica. Se concluye que la implementación de un programa ajedrez influye en el desarrollo de habilidades intelectuales en escolares de la amazonia peruana

Definition of the viral targets of protective HIV-1-specific T cell responses

<p>Abstract</p> <p>Background</p> <p>The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine designs are largely based on viral sequence alignments only, not incorporating experimental data on T cell function and specificity.</p> <p>Methods</p> <p>Here, 950 untreated HIV-1 clade B or -C infected individuals were tested for responses to sets of 410 overlapping peptides (OLP) spanning the entire HIV-1 proteome. For each OLP, a "protective ratio" (PR) was calculated as the ratio of median viral loads (VL) between OLP non-responders and responders.</p> <p>Results</p> <p>For both clades, there was a negative relationship between the PR and the entropy of the OLP sequence. There was also a significant additive effect of multiple responses to beneficial OLP. Responses to beneficial OLP were of significantly higher functional avidity than responses to non-beneficial OLP. They also had superior in-vitro antiviral activities and, importantly, were at least as predictive of individuals' viral loads than their HLA class I genotypes.</p> <p>Conclusions</p> <p>The data thus identify immunogen sequence candidates for HIV and provide an approach for T cell immunogen design applicable to other viral infections.</p

Definition of the viral targets of protective HIV-1-specific T cell responses

Background: The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine designs are largely based on viral sequence alignments only, not incorporating experimental data on T cell function and specificity. Methods: Here, 950 untreated HIV-1 clade B or -C infected individuals were tested for responses to sets of 410 overlapping peptides (OLP) spanning the entire HIV-1 proteome. For each OLP, a “protective ratio” (PR) was calculated as the ratio of median viral loads (VL) between OLP nonresponders and responders. Results: For both clades, there was a negative relationship between the PR and the entropy of the OLP sequence. There was also a significant additive effect of multiple responses to beneficial OLP. Responses to beneficial OLP were of significantly higher functional avidity than responses to non-beneficial OLP. They also had superior in-vitro antiviral activities and, importantly, were at least as predictive of individuals’ viral loads than their HLA class I genotypes. Conclusions: The data thus identify immunogen sequence candidates for HIV and provide an approach for T cell immunogen design applicable to other viral infections.Peer Reviewe