Towards displacing domestic air conditioning in KSA, an assessment of hybrid cooling strategies integrated with 'Fabric First' passive design measures

Reducing energy use and CO2 emissions to curb global warming and climate change are the greatest challenges now facing mankind. The vast majority of energy generated from fossil fuels is burned to run vehicles, fuel power stations and cool or heat homes. Saudi Arabia, the world's largest producer and exporter of petroleum, currently consumes almost three times higher than the world average energy use and hence; ranked ninth among nations for CO2 emissions. Among all fossil energy consumers, residential buildings use almost half of the Saudi's prime energy sources and are responsible for almost 50% of the emitted CO2. In such a hot climate region, air conditioning (AC) of dwellings is by far the major consumer representing 69% of domestic energy use and drives peak loading. Future projections predict a continuous increase in energy use as the majority of existing buildings are poorly designed for the prevailing climate, leading to excessive use of mechanical AC. Therefore, it is crucial for Saudi Arabia to consider a horizon where hydrocarbons are not the dominant energy resource. The adoption of energy efficiency measures and low carbon cooling strategies may have the potential to displace a substantial percentage of oil currently used to run conventional AC plants. Therefore, the current study investigates the viability of 'fabric first' intelligent architectural design measures, in combination with hybrid ground cooling pipes integrated with black-body radiant night cooling systems, with a specific purpose to displace AC systems and decrease the carbon footprint while sustaining year-round thermal comfort. The interrogation of this hypothesis was addressed in three stages. The first stage was to generate a baseline analysis of the thermo-physical and energy performance of a typical residential block in Jeddah. The second stage involved developing an alternative low energy cooling approach that could handle high ambient temperatures. The task involved designing ground pipe ventilation integrated with high emissivity blackbody radiator to displace AC systems. The design of such 'hybrid' system required a parametric analysis combined with testing prototypes in field trials to establish actual ground temperatures at various depths and black body emissivity ranges under different sky conditions. This hybrid system became the subject of numerical modelling and simulation using DesignBuilder software in conjunction with EnergyPlus simulation engine. The third stage was to assess the simulation results and validate the cooling efficiency and cost-effectiveness of the hybrid system compared to the baseline. The preliminary results of prototype thermal simulation and field trials suggest that 'fabric first' passive designs and measures (PDMs), combined with night hydronic radiant cooling (HRCS) and supply ventilation via ground pipes (GPCS), can negate the necessity for a standard AC system by displacing over 80% of cooling demand and lower the carbon footprint of a typical housing block by over 75%. Such passive and hybrid system applications also have a remarkably short payback period with energy savings offsetting the capital costs associated with building thermo-physical enhancement.Reducing energy use and CO2 emissions to curb global warming and climate change are the greatest challenges now facing mankind. The vast majority of energy generated from fossil fuels is burned to run vehicles, fuel power stations and cool or heat homes. Saudi Arabia, the world's largest producer and exporter of petroleum, currently consumes almost three times higher than the world average energy use and hence; ranked ninth among nations for CO2 emissions. Among all fossil energy consumers, residential buildings use almost half of the Saudi's prime energy sources and are responsible for almost 50% of the emitted CO2. In such a hot climate region, air conditioning (AC) of dwellings is by far the major consumer representing 69% of domestic energy use and drives peak loading. Future projections predict a continuous increase in energy use as the majority of existing buildings are poorly designed for the prevailing climate, leading to excessive use of mechanical AC. Therefore, it is crucial for Saudi Arabia to consider a horizon where hydrocarbons are not the dominant energy resource. The adoption of energy efficiency measures and low carbon cooling strategies may have the potential to displace a substantial percentage of oil currently used to run conventional AC plants. Therefore, the current study investigates the viability of 'fabric first' intelligent architectural design measures, in combination with hybrid ground cooling pipes integrated with black-body radiant night cooling systems, with a specific purpose to displace AC systems and decrease the carbon footprint while sustaining year-round thermal comfort. The interrogation of this hypothesis was addressed in three stages. The first stage was to generate a baseline analysis of the thermo-physical and energy performance of a typical residential block in Jeddah. The second stage involved developing an alternative low energy cooling approach that could handle high ambient temperatures. The task involved designing ground pipe ventilation integrated with high emissivity blackbody radiator to displace AC systems. The design of such 'hybrid' system required a parametric analysis combined with testing prototypes in field trials to establish actual ground temperatures at various depths and black body emissivity ranges under different sky conditions. This hybrid system became the subject of numerical modelling and simulation using DesignBuilder software in conjunction with EnergyPlus simulation engine. The third stage was to assess the simulation results and validate the cooling efficiency and cost-effectiveness of the hybrid system compared to the baseline. The preliminary results of prototype thermal simulation and field trials suggest that 'fabric first' passive designs and measures (PDMs), combined with night hydronic radiant cooling (HRCS) and supply ventilation via ground pipes (GPCS), can negate the necessity for a standard AC system by displacing over 80% of cooling demand and lower the carbon footprint of a typical housing block by over 75%. Such passive and hybrid system applications also have a remarkably short payback period with energy savings offsetting the capital costs associated with building thermo-physical enhancement

Attitudes among young adults in Palestine about peers with substance use problems: Challenges and opportunities for community intervention design

Social reintegration is necessary to support people in recovery from addiction, but it is often difficult in Palestine due to stigma. Bin Hussein’s instrument for measuring receptivity to social reintegration in various contexts in Saudi Arabia was employed for comparison in the West Bank. Data were collected in 2013 at Al-Quds University at the Abu Dis campus. More than half of the respondents have moderate attitudes toward social reintegration of people in recovery. There were no significant relationships between perceptions about social reintegration and gender, age, year in college, area of academic focus, and form of residence. Implications are discussed.The author(s) received no financial support for the research, authorship, and/or publication of this article

Heparan sulphate inhibition of cell proliferation induced by TGFβ and PDGF

The effect of glycosaminoglycans (GAGs) on the proliferation of smooth muscle cells (SMC) and fibroblasts was assessed by culturing cells with or without GAGs. Porcine heparan sulphate (HS) inhibited proliferation in a dose dependent manner. At 167 μg/ml of HS this reached 88% and 72% inhibition of SMC and fibroblast growth, respectively. Pig and beef mucosal heparins also blocked proliferation, but to a lesser extent. In contrast, beef lung heparin, chondroitin sulphate, and dermatan sulphate failed to block growth factor induced proliferation. Continuous presence of HS was not required, suggesting that the inhibitory effects resulted from a direct effect on the cell rather than an interaction of the GAG with growth factors. The mechanism by which GAGs inhibit proliferation will be addressed in future studies

Assessing capacity to engage in healthcare to improve the patient experience through health information technology

Patient engagement is viewed as a means to improve patient care, increase population health, and decrease health care costs. Efforts to improve engagement are prevalent across healthcare, particularly through health information technology (HIT) tools such as patient portals. However, we know that not all patients have the same ability to engage, leading to potential disparities. We present the Engagement Capacity Framework and suggest that examining capacity for engagement would improve our ability to address currently unmeasured factors that facilitate engagement. The objective was to examine factors that influence an individual’s capacity for engagement through HIT. We administered a paper survey to patients seen for care in a Family Medicine Clinic at a large Academic Medical Center, measuring potential components of the Engagement Capacity Framework. 142 patients completed the survey. Respondents reported high self-efficacy, high resilience, and good or better quality of life. Most were willing to use the Internet. Almost 30% of respondents did not use a patient portal and 37% of these respondents were very or somewhat unwilling to use a portal. We observed significant positive correlations (p \u3e 0.05) between portal use and searching for health information online, using email and owning technology. For those who did not use a portal we asked about willingness to use a portal; portal willingness was positively correlated with willingness to use the Internet (p \u3c 0.01). Our findings emphasize the importance of assessing capacity for engagement in order to target interventions to those most in need, connecting them to necessary resources to allow more full participation in their care. Experience Framework This article is associated with the Innovation & Technology lens of The Beryl Institute Experience Framework. (http://bit.ly/ExperienceFramework) Access other PXJ articles related to this lens. Access other resources related to this len

Comparative analysis of core genome MLST and SNP typing within a European Salmonella serovar Enteritidis outbreak

Multi-country outbreaks of foodborne bacterial disease present challenges in their detection, tracking, and notification. As food is increasingly distributed across borders, such outbreaks are becoming more common. This increases the need for high-resolution, accessible, and replicable isolate typing schemes. Here we evaluate a core genome multilocus typing (cgMLST) scheme for the high-resolution reproducible typing of Salmonella enterica (S. enterica) isolates, by its application to a large European outbreak of S. enterica serovar Enteritidis. This outbreak had been extensively characterised using single nucleotide polymorphism (SNP)-based approaches. The cgMLST analysis was congruent with the original SNP-based analysis, the epidemiological data, and whole genome MLST (wgMLST) analysis. Combination of the cgMLST and epidemiological data confirmed that the genetic diversity among the isolates predated the outbreak, and was likely present at the infection source. There was consequently no link between country of isolation and genetic diversity, but the cgMLST clusters were congruent with date of isolation. Furthermore, comparison with publicly available Enteritidis isolate data demonstrated that the cgMLST scheme presented is highly scalable, enabling outbreaks to be contextualised within the Salmonella genus. The cgMLST scheme is therefore shown to be a standardised and scalable typing method, which allows Salmonella outbreaks to be analysed and compared across laboratories and jurisdictions. [Abstract copyright: Copyright © 2018. Published by Elsevier B.V.

Studying the Effect of Variables on Acyclovir Microsponge

The aim of the present investigation was to develop a microsponge delivery system of acyclovir to control its release when applied topically thereby reducing dosing frequency and enhancement patient compliance. The microsponges were produced by the oil in oil emulsion solvent diffusion method. The effect of different formulation and process variables such as internal phase volume, polymer type, drug-polymer ratio, stirring speed and stirring duration on microsponge production yield, loading efficiency, particle size and in-vitro drug release was evaluated. The result showed that the microsponge F2 prepared from Eudrajet RS polymer had optimum physical properties regarding the loading efficiency of 99.71_+ 0.7% and production yield which was 85%. Also, F2 showed 66% drug release within 8 hours. Accordingly, the oil in oil emulsion solvent diffusion method is an effective technique to formulate microsponges with maximum production yield and loading efficiency for acyclovir

Comparison of classical multi-locus sequence typing software for next-generation sequencing data

Multi-locus sequence typing (MLST) is a widely used method for categorizing bacteria. Increasingly, MLST is being performed using next-generation sequencing (NGS) data by reference laboratories and for clinical diagnostics. Many software applications have been developed to calculate sequence types from NGS data; however, there has been no comprehensive review to date on these methods. We have compared eight of these applications against real and simulated data, and present results on: (1) the accuracy of each method against traditional typing methods, (2) the performance on real outbreak datasets, (3) the impact of contamination and varying depth of coverage, and (4) the computational resource requirements

Aspirin and its Metabolites Enhance the Expression of Vascular Endothelial Growth Factor in Retinal Pigment Epithelial Cell Cultures – Implications in the Pathophysiology of Age-Related Macular Degeneration

Purpose: An estimated 19.3% of adults, especially the elderly in the United States regularly use Aspirin for cardioprotection. Recently, multiple cohort studies have concluded that regular aspirin use for 10-15 years was associated with a statistically significant increase in the risk of incident age-related and neovascular acute macular degeneration. It has been hypothesized that aspirin or its metabolites induce the expression of vascular endothelial growth factor (VEGF). Materials & Methods: Retinal pigment epithelial cells, ARPE-19 (ATCC®CRL-2302™) were cultured. The cells were grown to achieve 95% confluence and then the media was changed. Cells cultured under blue light, red light, or darkness were subjected to a challenge with high dose aspirin (0.925 mg/dL), low dose aspirin (0.325 mg/dL), or hippuric acid (0.325 mg/dL). Light was generated using 2 red or blue LEDs powered by 3v CR2032 batteries. The 24-well plate was incubated with or without drugs in blue light, red light or darkness at 37C for 16 hours. The supernatants were harvested, and VEGF was quantified. One-way ANOVA using Dunnett’s multiple comparison test was performed to analyze statistical significance. Results: Cells exposed to blue light or darkness and hippuric acid showed a statistically significant increase in VEGF secretion (P=0.0012). However, cells exposed to red light with hippuric acid challenge showed no significant difference from the mean of cells exposed to darkness and sham control. Conclusions: Retinal pigment epithelial cells challenged with oxidative stress provided by blue light or darkness in the presence of hippuric acid increased VEGF secretion, suggesting a possible cause for neovascularization in age-related macular degeneration. RPE cells exposed to red light, known to abrogate oxidative stress, had decreased levels of VEGF induction by hippuric acid

Pulsed Atomic Layer Epitaxy of Quaternary AlInGaN Layers

In this letter, we report on a material deposition scheme for quaternary AlxInyGa1−x–yN layers using a pulsed atomic layer epitaxy (PALE) technique. The PALE approach allows accurate control of the quaternary layer composition and thickness by simply changing the number of aluminum,indium, and gallium pulses in a unit cell and the number of unit cell repeats. Using PALE, AlInGaN layers with Al mole fractions in excess of 40% and strong room-temperature photoluminescence peaks at 280 nm can easily be grown even at temperatures lower than 800 °C