Pathologies associées aux mutations et polymorphismes du gène Cystic Fibrosis Transmembrane conductance Regulator ou CFTR

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

Rôle des microparticules endothéliales sur l'activation des cellules dendritiques et applications potentielles dans les pathologies inflammatoires

BESANCON-BU Médecine pharmacie (250562102) / SudocSudocFranceF

[Endothelial microparticles, an alarm signal for the immune system?]

International audienc

Phosphatidylserine-expressing cell by-products in transfusion: A pro-inflammatory or an anti-inflammatory effect?

International audienceLabile blood products contain phosphatidylserine-expressing cell dusts, including apoptotic cells and microparticles. These cell by-products are produced during blood product process or storage and derived from the cells of interest that exert a therapeutic effect (red blood cells or platelets). Alternatively, phosphatidylserine-expressing cell dusts may also derived from contaminating cells, such as leukocytes, or may be already present in plasma, such as platelet-derived microparticles. These cell by-products present in labile blood products can be responsible for transfusion-induced immunomodulation leading to either transfusion-related acute lung injury (TRALI) or increased occurrence of post-transfusion infections or cancer relapse. In this review, we report data from the literature and our laboratory dealing with interactions between antigen-presenting cells and phosphatidylserine-expressing cell dusts, including apoptotic leukocytes and blood cell-derived microparticles. Then, we discuss how these phosphatidylserine-expressing cell by-products may influence transfusion

[The role of dendritic cells in auto-inflammation seen in psoriasis]

International audienc

Correlation between platelet-derived microparticle enumeration by flow cytometry and phospholipid-dependent procoagulant activity in microparticles: the centrifugation step matters!

International audienc

Increased levels of circulating endothelial-derived microparticles and small-size platelet-derived microparticles in psoriasis.

International audienc