Analysis of the influence of nanoparticles in Photodynamic Therapy applied to biological tissues

Photodynamic Therapy (PDT) is a photo-optical treatment technique intended for malig- nant biological tissue destruction. An inoculated photosensitizer is optically irradiated and tumoral tissue is destroyed with great specificity, practically absent secondary effects and good aesthetic result. PDT is inefficient in thick tumoral tissues due mainly to the optical radiation and photo-sensitizer spatial distributions, and also to lesion-independent clinical protocols. In this work we analyse the use of different nanoparticles in PDT. Optical propagation, photosensitizer non-homogeneous spatial distribution and photochemical reactions are taken into account. A complex predictive model is used to estimate the treatment outcome and the influence of nanoparticles

Real-Time Optical Phase Conjugation for Scattering Compensation in Turbid Media

The possibility of scattering suppression effect for biological tissues based on the implementation of optical phase conjugation via four-wave mixing in a nonlinear medium has been analyzed. The process of short light pulse propagation through highly scattering media is modeled based on Finite-Difference Time-Domain calculations of Maxwell’s equations. The model for optical phase conjugation is derived based on coupled-mode equations for degenerate four-wave mixing in dye solutions. The scheme is experimentally analyzed for typical parameters of laser light beams and biological tissues in visible region of spectrum

Real-Time Optical Phase Conjugation for Scattering Compensation in Turbid Media

The possibility of scattering suppression effect for biological tissues based on the implementation of optical phase conjugation via four-wave mixing in a nonlinear medium has been analyzed. The process of short light pulse propagation through highly scattering media is modeled based on Finite-Difference Time-Domain calculations of Maxwell’s equations. The model for optical phase conjugation is derived based on coupled-mode equations for degenerate four-wave mixing in dye solutions. The scheme is experimentally analyzed for typical parameters of laser light beams and biological tissues in visible region of spectrum

A multinational Delphi consensus to end the COVID-19 public health threat

Abstract Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches , while maintaining proven prevention measures using a vaccines-plus approach that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end

A multinational Delphi consensus to end the COVID-19 public health threat

Abstract Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic 1,2 . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches 1 , while maintaining proven prevention measures using a vaccines-plus approach 2 that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities 3 in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end

A multinational Delphi consensus to end the COVID-19 public health threat

Abstract Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic 1,2 . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches 1 , while maintaining proven prevention measures using a vaccines-plus approach 2 that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities 3 in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end