RESEARCH ON THE ASEISMIC BEHAVIOR OF LONG-SPAN CABLE-STAYED BRIDGE WITH DAMPING EFFECT

The main beam of a cable-stayed bridge with a floating system may have a larger longitudinal displacement subject to earthquake effect. Thus, seismic control and isolation are crucial to bridge safety. This paper takes Huai’an Bridge, which has elastic coupling devices and viscous dampers set at the joint of the tower and the beam, as the research background. Its finite element model is established, and the elastic stiffness of elastic coupling devices and damper parameters are analyzed. Viscous damper and elastic coupling devices are simulated using Maxwell model and spring elements, and their damping effects are analyzed and compared through structural dynamic time-history analysis. Results show that viscous damper and elastic coupling device furnished at the joint of tower and beam of a cable-stayed bridge tower beam can effectively reduce the longitudinal displacement of the key part of the construction subject to earthquake effect, perfect the internal force distribution, and improve the aseismic performance. Between the two, viscous damper has better damping effects

Masked Collaborative Contrast for Weakly Supervised Semantic Segmentation

This study introduces an efficacious approach, Masked Collaborative Contrast (MCC), to emphasize semantic regions in weakly supervised semantic segmentation. MCC adroitly incorporates concepts from masked image modeling and contrastive learning to devise Transformer blocks that induce keys to contract towards semantically pertinent regions. Unlike prevalent techniques that directly eradicate patch regions in the input image when generating masks, we scrutinize the neighborhood relations of patch tokens by exploring masks considering keys on the affinity matrix. Moreover, we generate positive and negative samples in contrastive learning by utilizing the masked local output and contrasting it with the global output. Elaborate experiments on commonly employed datasets evidences that the proposed MCC mechanism effectively aligns global and local perspectives within the image, attaining impressive performance. The source code is available at \url{https://github.com/fwu11/MCC}

Examining the generalizability of research findings from archival data

This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability—for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples

Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system

BACKGROUND: Plasma coagulation Factor XIIa (Hageman factor; encoded by F12) and kallikrein (KAL or Fletcher factor; encoded by KLKB1) are proteases of the kallikerin-kinin system involved in converting the inactive circulating prorenin to renin. Renin is a key enzyme in the formation of angiotensin II, which regulates blood pressure, fluid and electrolyte balance and is a biomarker for cardiovascular, metabolic and renal function. The renin-angiotensin system is implicated in extinction learning in posttraumatic stress disorder. METHODS & RESULTS: Active plasma renin was measured from two independent cohorts- civilian twins and siblings, as well as U.S. Marines, for a total of 1,180 subjects. Genotyping these subjects revealed that the carriers of the minor alleles at the two loci- F12 and KLKB1 had a significant association with reduced levels of active plasma renin. Meta-analyses confirmed the association across cohorts. In vitro studies verified digestion of human recombinant pro-renin by kallikrein (KAL) to generate active renin. Subsequently, the active renin was able to digest the synthetic substrate angiotensinogen to angiotensin-I. Examination of mouse juxtaglomerular cell line and mouse kidney sections showed co-localization of KAL with renin. Expression of either REN or KLKB1 was regulated in cell line and rodent models of hypertension in response to oxidative stress, interleukin or arterial blood pressure changes. CONCLUSIONS: The functional variants of KLKB1 (rs3733402) and F12 (rs1801020) disrupted the cascade of enzymatic events, resulting in diminished formation of active renin. Using genetic, cellular and molecular approaches we found that conversion of zymogen prorenin to renin was influenced by these polymorphisms. The study suggests that the variant version of protease factor XIIa due to the amino acid substitution had reduced ability to activate prekallikrein to KAL. As a result KAL has reduced efficacy in converting prorenin to renin and this step of the pathway leading to activation of renin affords a potential therapeutic target

RESEARCH ON THE ASEISMIC BEHAVIOR OF LONG-SPAN CABLE-STAYED BRIDGE WITH DAMPING EFFECT

The main beam of a cable-stayed bridge with a floating system may have a larger longitudinal displacement subject to earthquake effect. Thus, seismic control and isolation are crucial to bridge safety. This paper takes Huai’an Bridge, which has elastic coupling devices and viscous dampers set at the joint of the tower and the beam, as the research background. Its finite element model is established, and the elastic stiffness of elastic coupling devices and damper parameters are analyzed. Viscous damper and elastic coupling devices are simulated using Maxwell model and spring elements, and their damping effects are analyzed and compared through structural dynamic time-history analysis. Results show that viscous damper and elastic coupling device furnished at the joint of tower and beam of a cable-stayed bridge tower beam can effectively reduce the longitudinal displacement of the key part of the construction subject to earthquake effect, perfect the internal force distribution, and improve the aseismic performance. Between the two, viscous damper has better damping effects

Experimental Investigation on the Mechanical Performance of Steel-ECC Composite Girders with Corrugated Webs under Negative Moment

In order to improve the cracking performance in the negative moment region of composite continuous girder bridges with corrugated webs, engineered cementitious composite (ECC) is used instead of conventional normal concrete (NC). Web and concrete types are used as the main research parameters in experiments. The test results indicate that steel-ECC specimens have a higher flexural load capacity and stiffness than steel-NC specimens. The cracks of steel-ECC specimens are characterised by small width and dense distribution. Nonlinear finite element models are established and verified by experimental results. The simulated load–displacement curves are similar to the experimental ones, and the models have a high degree of accuracy. The ECC slab strength, thickness and width are used as parameters for the investigation to analyse the effect of the ECC slab on the flexural bearing capacity of composite girders. Compared with the results of calculations according to the code, the bearing capacity obtained from the parametric analysis is higher. It suggests that the contribution of the ECC slab needs to be considered when calculating the bearing capacity of the steel-ECC composite girder with corrugated webs