Phase transition of holographic entanglement entropy in massive gravity

The phase structure of holographic entanglement entropy is studied in massive gravity for the quantum systems with finite and infinite volumes, which in the bulk is dual to calculate the minimal surface area for a black hole and black brane respectively. In the entanglement entropy$-$temperature plane, we find for both the black hole and black brane there is a Van der Waals-like phase transition as the case in thermal entropy$-$temperature plane. That is, there is a first order phase transition for the small charge and a second order phase transition at the critical charge. For the first order phase transition, the equal area law is checked and for the second order phase transition, the critical exponent of the heat capacity is obtained. All the results show that the phase structure of holographic entanglement entropy is the same as that of thermal entropy regardless of the volume of the spacetime on the boundary.Comment: 15 pages, many figures, some statments are adde

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins

In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ... See full text for complete abstract

CO (J = 1–0) Observations toward Filamentary Molecular Clouds in the Galactic Region with l = [169.°75, 174.°75], b = [−0.°75, 0.°5]

We present observations of the CO isotopologues (12CO, 13CO, and C18O) toward the Galactic region with 169fdg75 ≤ l ≤ 174fdg75 and −0fdg75 ≤ b ≤ 0fdg5 using the Purple Mountain Observatory 13.7 m millimeter-wavelength telescope. Based on the 13CO (J = 1 − 0) data, we find five molecular clouds within the velocity range between −25 and 8 km s−1 that are all characterized by conspicuous filamentary structures. We have identified eight filaments with a length of 6.38–28.45 pc, a mean H2 column density of 0.70 × 1021–6.53 × 1021 cm−2, and a line mass of 20.24–161.91 M ☉ pc−1, assuming a distance of ~1.7 kpc. Gaussian fittings to the inner parts of the radial density profiles lead to a mean FWHM width of 1.13 ± 0.01 pc. The velocity structures of most filaments present continuous distributions with slight velocity gradients. We find that turbulence is the dominant internal pressure to support the fragmentation of filaments instead of thermal pressure. Most filaments have virial parameters smaller than 2; thus, they are gravitationally bound. Four filaments have an LTE line mass close to the virial line mass. We further extract dense clumps using the 13CO data and find that 64% of the clumps are associated with the filaments. According to the complementary IR data, most filaments have associated Class II young stellar objects. Class I objects are mainly found to be located in the filaments with a virial parameter close to 1. Within two virialized filaments, 12CO outflows have been detected, indicating ongoing star-forming activity therein.National Key Research & Development of China [2017YFA0402702]; European Unions Horizon 2020 research and innovation program [639459]; NSFC [11473069, 11503086, 11629302]This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Draft Genome of the Leopard Gecko, \u3cem\u3eEublepharis Macularius\u3c/em\u3e

Background Geckos are among the most species-rich reptile groups and the sister clade to all other lizards and snakes. Geckos possess a suite of distinctive characteristics, including adhesive digits, nocturnal activity, hard, calcareous eggshells, and a lack of eyelids. However, one gecko clade, the Eublepharidae, appears to be the exception to most of these ‘rules’ and lacks adhesive toe pads, has eyelids, and lays eggs with soft, leathery eggshells. These differences make eublepharids an important component of any investigation into the underlying genomic innovations contributing to the distinctive phenotypes in ‘typical’ geckos. Findings We report high-depth genome sequencing, assembly, and annotation for a male leopard gecko, Eublepharis macularius (Eublepharidae). Illumina sequence data were generated from seven insert libraries (ranging from 170 to 20 kb), representing a raw sequencing depth of 136X from 303 Gb of data, reduced to 84X and 187 Gb after filtering. The assembled genome of 2.02 Gb was close to the 2.23 Gb estimated by k-mer analysis. Scaffold and contig N50 sizes of 664 and 20 kb, respectively, were compble to the previously published Gekko japonicus genome. Repetitive elements accounted for 42 % of the genome. Gene annotation yielded 24,755 protein-coding genes, of which 93 % were functionally annotated. CEGMA and BUSCO assessment showed that our assembly captured 91 % (225 of 248) of the core eukaryotic genes, and 76 % of vertebrate universal single-copy orthologs. Conclusions Assembly of the leopard gecko genome provides a valuable resource for future comptive genomic studies of geckos and other squamate reptiles

Pathogenic Cav3.2 channel mutation in a child with primary generalized epilepsy.

Two paternally-inherited missense variants in CACNA1H were identified and characterized in a 6-year-old child with generalized epilepsy. Febrile and unprovoked seizures were present in this child. Both variants were expressed in cis or isolation using human recombinant Cav3.2 calcium channels in tsA-201 cells. Whole-cell patch-clamp recordings indicated that one variant (c.3844C > T; p.R1282W) caused a significant increase in current density consistent with a pathogenic gain-of-function phenotype; while the other cis-related variant (c.5294C > T; p.A1765V) had a benign profile

One-shot ultraspectral imaging with reconfigurable metasurfaces

One-shot spectral imaging that can obtain spectral information from thousands of different points in space at one time has always been difficult to achieve. Its realization makes it possible to get spatial real-time dynamic spectral information, which is extremely important for both fundamental scientific research and various practical applications. In this study, a one-shot ultraspectral imaging device fitting thousands of micro-spectrometers (6336 pixels) on a chip no larger than 0.5 cm$^2$, is proposed and demonstrated. Exotic light modulation is achieved by using a unique reconfigurable metasurface supercell with 158400 metasurface units, which enables 6336 micro-spectrometers with dynamic image-adaptive performances to simultaneously guarantee the density of spectral pixels and the quality of spectral reconstruction. Additionally, by constructing a new algorithm based on compressive sensing, the snapshot device can reconstruct ultraspectral imaging information ($\Delta\lambda$/$\lambda$~0.001) covering a broad (300-nm-wide) visible spectrum with an ultra-high center-wavelength accuracy of 0.04-nm standard deviation and spectral resolution of 0.8 nm. This scheme of reconfigurable metasurfaces makes the device can be directly extended to almost any commercial camera with different spectral bands to seamlessly switch the information between image and spectral image, and will open up a new space for the application of spectral analysis combining with image recognition and intellisense