416 research outputs found
Bacterial IgA Protease-mediated Degradation of agIgA1 and Its Immune Complex as a Potential Novel Therapy for IgA Nephropathy
High resolution optical time-domain reflectometry based on correlation utilizing an all-fiber chaotic source
We propose a high-resolution optical time domain reflectometry (OTDR) based on an all-fiber supercontinuum source. The source simply consists of a laser with moderate power and a section of fiber which has a zero dispersion wavelength near the laser's central wavelength. Spectrum and time domain properties of the source are investigated, showing that the source has great capability in nonlinear optics, such as correlation OTDR. We analyze one of the key factors limiting the operational range of such an OTDR, i.e., sampling time. Finally, we experimentally demonstrate a correlation OTDR with 25km sensing range and 5.3cm spatial resolution, as a verification of theoretical analysis
Long-range and high-resolution correlation optical time-domain reflectometry utilizing an all optical chaotic source
A high resolution optical time domain reflectometry (OTDR) based on an all-fiber chaotic source is demonstrated. We analyze the key factors limiting the operational range of such an OTDR, e.g., integral Rayleigh backscattering and the fiber loss, which degrade the optical signal to noise ratio at the receiver side, and then the guideline for counter-act such signal fading is discussed. The experimentally demonstrated correlation OTDR presents ability of 100km sensing range and 8.2cm spatial resolution (1.2 million resolved points), as a verification of the theoretical analysis. To the best of our knowledge, this is the first time that correlation OTDR measurement is performed over such a long distance with such high precision
Arginine deficiency augments inflammatory mediator production by airway epithelial cells in vitro
Tissue of origin, but not XCI state, influences germ cell differentiation from human pluripotent stem cells
Stem cells & developmental biolog
Single-cell transcriptomics analysis of human small antral follicles
Stem cells & developmental biolog
Cell-cell interactions during the formation of primordial follicles in humans
Gametogenesis is a complex and sex-specific multistep process during which the gonadal somatic niche plays an essential regulatory role. One of the most crucial steps during human female gametogenesis is the formation of primordial follicles, the functional unit of the ovary that constitutes the pool of follicles available at birth during the entire reproductive life. However, the relation between human fetal germ cells (hFGCs) and gonadal somatic cells during the formation of the primordial follicles remains largely unexplored. We have discovered that hFGCs can form multinucleated syncytia, some connected via interconnecting intercellular bridges, and that not all nuclei in hFGC–syncytia were synchronous regarding meiotic stage. As hFGCs progressed in development, pre-granulosa cells formed protrusions that seemed to progressively constrict individual hFGCs, perhaps contributing to separate them from the multinucleated syncytia. Our findings highlighted the cell–cell interaction and molecular dynamics between hFGCs and (pre)granulosa cells during the formation of primordial follicles in humans. Knowledge on how the pool of primordial follicle is formed is important to understand human infertility. </p
Effect of Initial Disturbance on The Detonation Front Structure of a Narrow Duct
The effect of an initial disturbance on the detonation front structure in a
narrow duct is studied by three-dimensional numerical simulation. The numerical
method used includes a high resolution fifth-order weighted essentially
non-oscillatory scheme for spatial discretization, coupled with a third order
total variation diminishing Runge-Kutta time stepping method. Two types of
disturbances are used for the initial perturbation. One is a random disturbance
which is imposed on the whole area of the detonation front, and the other is a
symmetrical disturbance imposed within a band along the diagonal direction on
the front. The results show that the two types of disturbances lead to
different processes. For the random disturbance, the detonation front evolves
into a stable spinning detonation. For the symmetrical diagonal disturbance,
the detonation front displays a diagonal pattern at an early stage, but this
pattern is unstable. It breaks down after a short while and it finally evolves
into a spinning detonation. The spinning detonation structure ultimately formed
due to the two types of disturbances is the same. This means that spinning
detonation is the most stable mode for the simulated narrow duct. Therefore, in
a narrow duct, triggering a spinning detonation can be an effective way to
produce a stable detonation as well as to speed up the deflagration to
detonation transition process.Comment: 30 pages and 11 figure
Effects of polysaccharide from Ophiopogon japonicus on immune response to Newcastle disease vaccine in chicken
Hot deformation behavior and processing maps of diamond/Cu composites
The hot deformation behaviors of 50 vol pct uncoated and Cr-coated diamond/Cu composites were investigated using hot isothermal compression tests under the temperature and strain rate ranging from 1073 K to 1273 K (800 C to 1000 C) and from 0.001 to 5 s1, respectively. Dynamic recrystallization was determined to be the primary restoration mechanism during deformation. The Cr3C2 coating enhanced the interfacial bonding and resulted in a larger flow stress for the Cr-coated diamond/Cu composites. Moreover, the enhanced interfacial affinity led to a higher activation energy for the Cr-coated diamond/Cu composites (238 kJ/mol) than for their uncoated counterparts (205 kJ/mol). The strain-rate-dependent constitutive equations of the diamond/Cu composites were derived based on the Arrhenius model, and a high correlation (R = 0.99) was observed between the calculated flow stresses and experimental data. With the help of processing maps, hot extrusions were realized at 1123 K/0.01 s1 and 1153 K/0.01 s1 (850 C/0.01 s1 and 880 C/0.01 s1) for the uncoated and coated diamond/Cu composites, respectively. The combination of interface optimization and hot extrusion led to increases of the density and thermal conductivity, thereby providing a promising route for the fabrication of diamond/Cu composites
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