Neutral Bystander, Intrusive Micromanager, or Useful Catalyst?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73380/1/j.1541-0072.1995.tb01746.x.pd

Evidence that a nucleotide sequence, "boxA," is involved in the action of the NusA protein

We report the isolation of a mutation, boxA 1, in the nutR region of the phage [lambda] genome. The nutR region, located downstream of the pR promoter, includes the site nutR where the [lambda] N protein is thought to act to render subsequent transcription termination-resistant. We have previously suggested that the boxA sequence, 5'CGCTCTTA3' (or its RNA analog), located 8 bp promoter-proximal to nutR, might be the recognition site for the E. coli host factor, NusA, which has been shown to be necessary for N action. The boxA1 mutation, an A:T to T:A transversion, results in a changed boxA sequence upstream of nutR, CGCTCTTT. This change is necessary for [lambda] to effectively use the NusA of Salmonella typhimurium, a NusA function not normally active with the N product of [lambda]. Other lambdoid phages with unique N functions and nut sites that are normally active with the NusA of Salmonella have boxA sequences with the terminal three Ts. Moreover, sequences closely resembling boxA have been found near transcription termination sequences in E. coli operons where NusA has been shown to be involved in termination. These findings identify boxA as an important recognition signal for the NusA protein.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25144/1/0000580.pd

Forest Service Budget Requests and Appropriations

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74374/1/j.1541-0072.1995.tb01741.x.pd

Tangled webs? Managing local mixed economies of care

This article addresses two main issues about the emergent forms of social care provision in the development of a more mixed economy of welfare in Britain in the 1990s. The first concerns patterns of inter-organizational relationship within local mixed economies of care, paying particular attention to the inter-section of competitive and collaborative models of such relationships. The second concerns the emergence of a'managerial mode of co-ordination'as the dominant force in ordering intra- and inter-organizational relationships in such mixed economies. The article draws on research conducted in two such local mixed economies of care and addresses some of the theoretical problems involved in trying to analyse these new patterns of relationship

Litigating Agency Change

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71679/1/j.1541-0072.1995.tb01745.x.pd