Educational building conditions and the health of users

In order to maintain a healthy learning environment, diagnosis and management of defects in the educational facility are paramount. The preliminary results of the ongoing research reported here seek to identify defects associated with educational buildings and their effects on the health of polytechnic students and staff in Nigeria. A questionnaire survey, including 34 defects based on a post-occupancy evaluation (POE) was used to establish relationships with the health of polytechnic students and staff. Two hundred (200) respondents were randomly selected based on their schools (faculty) within Lagos State Polytechnic. Descriptive and inferential statistics were used for analysis of the collected data. The results of the study indicate that defects such as plumbing and dampness problems, cobwebs and dust, are prominent in the institution. Also the relationship between building conditions (defects) and health problems was established, with the predictors of the health problems. Based on the findings, it is important for designers and managers of facilities within tertiary institutions to develop and implement design and maintenance policies targeted at minimizing the likelihood of plumbing, dampness, electrical, cobweb and dust problems in educational buildings due to the health risks induced by the defects. It is evident that effective maintenance schedules and policies should be put in place to ensure that facilities are not left to decay before replacement

"Test me and treat me" - attitudes to vitamin D deficiency and supplementation: a qualitative study

© 2015 BMJ Open, "Test me and treat me"-attitudes to vitamin D deficiency and supplementation: a qualitative study. This manuscript version is made available under the Creative Commons Attribution Licens

Impact of Construction Health & Safety Regulations on Project Parameters in Nigeria: Consultants and Contractors View

The effectiveness of the construction industry can only be enhanced by repositioning the construction health and safety regulations to safeguard the health of the workers and the entire community. This paper seeks to assess the views of consultants and contractors about the impact of construction health and safety regulations in Nigeria. Data was collected using the questionnaire survey distributed among construction professionals and statistical tools employed include tables, percentages and mean score ranking. The study revealed that construction health and safety is still perceived to be more important than the traditional project parameters in the form of cost, time and quality. Designers perceive that an enhanced environment is the resultant impact of construction health and safety regulations while quantity surveyors see improved quality as having the resultant impact while contractors perceive improved maintenance as having the resultant impact on health and safety regulation. The study recommends that better attention is given to health and safety should as a project parameter and that related practice notes and guidelines should be evolved for all project stakeholders

Building Information Modeling Execution Drivers for Sustainable Building Developments

The need for continuous global improvement in the construction industry’s current state is inevitable. This pursuit for advancement is to benefit all concerned stakeholders in the construction industry, and innovation has been acknowledged as this improvement measure. Interestingly, Building Information Model (BIM) is a typical example of such innovation in the construction industry. It circumvents human errors, lessening project costs, strengthening productivity and quality, and reducing the project delivery time. This analysis investigates the factors influencing BIM implementation in construction in developing nations. A comprehensive literature review was performed to determine what factors contribute to BIM adoption. These drivers were categorized using exploratory factor analysis (EFA). Partial Least Square Structural Equation Modeling (PLS-SEM) was also used with a questionnaire survey of 100 Nigerian building engineering professionals. Findings from the model highlight the most critical drivers of sustainable BIM deployment. The study’s conclusion will serve as a guideline for policymakers in developing nations that want to finish successful projects by avoiding BIM implementation drivers and improving the accomplishment of building projects via the usage of BIM

Downstream Toll-like receptor signaling mediates adaptor-specific cytokine expression following focal cerebral ischemia

<p>Abstract</p> <p>Background</p> <p>Deletion of some Toll-like receptors (TLRs) affords protection against cerebral ischemia, but disruption of their known major downstream adaptors does not. To determine whether compensation in the production of downstream effectors by one pathway when the other is disrupted can explain these findings, we examined cytokine/chemokine expression and inflammatory infiltrates in wild-type (WT), MyD88^−/− and TRIF-mutant mice following permanent middle cerebral artery occlusion (pMCAO).</p> <p>Methods</p> <p>Cytokine/chemokine expression was measured with a 25-plex bead array in the serum and brains of all three groups of mice at baseline (no surgery/naïve) and at 3 hours and 24 hours following pMCAO. Brain inflammatory and neutrophil infiltrates were examined 24 hours following pMCAO.</p> <p>Results</p> <p>IL-6, keratinocyte chemoattractant (KC), granulocyte colony-stimulating factor (G-CSF) and IL-10 were significantly decreased in MyD88^−/− mice compared to WT mice following pMCAO. Significantly, decreased levels of the neutrophil chemoattractants KC and G-CSF corresponded with a trend toward fewer neutrophils in the brains of MyD88^−/− mice. IP-10 was significantly decreased when either pathway was disrupted. MIP-1α was significantly decreased in TRIF-mutant mice, consistent with TRIF-dependent production. MyD88^−/− mice showed elevations of a number of Th2 cytokines, such as IL-13, at baseline, which became significantly decreased following pMCAO.</p> <p>Conclusions</p> <p>Both MyD88 and TRIF mediate pathway-specific cytokine production following focal cerebral ischemia. Our results also suggest a compensatory Th2-type skew at baseline in MyD88^−/− mice and a paradoxical switch to a Th1 phenotype following focal cerebral ischemia. The MyD88 pathway directs the expression of neutrophil chemoattractants following cerebral ischemia.</p

MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke

Neuroinflammation is critical in the neural cell death seen in stroke. It has been shown that CNS and peripheral responses drive this neuroinflammatory response in the brain. The Toll-like receptors (TLRs) are important regulators of inflammation in response to both exogenous and endogenous stressors. Taking advantage of a downstream adapter molecule that controls the majority of TLR signalling, this study investigated the role of the TLR adaptor protein myeloid differentiation factor 88 (MyD88) in the control of CNS and peripheral inflammation. Reversible middle-cerebral artery occlusion was used as the model of stroke in vivo; in vitro primary cultured neurons and glia were subject to four hours of oxygen and glucose deprivation (OGD). Both in vitro and in vivo Myd88(-/-) animals or cells were compared with wild type (WT). We found that after stroke Myd88(-/-) animals have a larger infarct volume compared to WT animals. Interestingly, in vitro there was no difference between the survival of Myd88(-/-) and WT cells following OGD, suggesting that peripheral responses were influencing stroke outcome. We therefore generated bone marrow chimeras and found that Myd88(-/-) animals have a smaller stroke infarct than their radiation naive counterparts if their hematopoietic cells are WT. Furthermore, WT animals have a larger stroke than their radiation naive counterparts if the hematopoietic cells are Myd88(-/-) . We have demonstrated that MyD88-dependent signalling in the hematopoietic cell lineage reduces infarct size following stroke and that infiltrating cells to the site of neuroinflammation are neuroprotective following stroke.Catherine E. Downes, Connie H. Y. Wong, Katya J. Henley, Pedro L. Guio-Aguilar, Moses Zhang, Robert Ates, Ashley Mansell, Benjamin T. Kile, Peter J. Crac