Développement natif, xamarin, hybride ou web: critères de choix et arbre de décision pour un développement mobile

En l’espace d’une dizaine d’années, le marché des mobiles intelligents s’est beaucoup développé. Trois entreprises se partagent le marché : Google avec Android, Apple avec iOS et Microsoft avec Windows Phone. Chacun propose une approche différente et un ensemble d’outils afin de concevoir une application mobile sous la forme de développement natif. Il profite de toute la puissance et les accélérations matérielles pour fournir la meilleure expérience utilisateur. Cependant, chaque plateforme nécessite un développement spécifique qui implique un investissement important en matière de développement, de maintenance et d’évolution afin de pouvoir distribuer une application sur les différents stores. Le développement d’une application web constitue une alternative qui pourra s’exécuter dans un navigateur internet sans se soucier du système d’exploitation. Elle possède néanmoins plusieurs inconvénients. Plus récemment, de nouveaux outils ont vu le jour avec pour ambition de simplifier le développement d’application mobile multiplateforme. Alors comment choisir quel type de développement est le plus approprié lorsqu’on veut concevoir une nouvelle application mobile ? Est-ce qu’une solution est toujours meilleure qu’une autre ? Quels sont les avantages et les inconvénients de chacune ? Ce travail a pour objectif d’analyser ces différentes solutions. Pour cela, les critères suivants seront analysés à travers la création de divers prototypes : Accès aux fonctionnalités : Toutes les plateformes ont-elles accès de la même façon au hardware des smartphones ? Stockage local : Dans quelle mesure pouvons-nous archiver temporairement et durablement du contenu dans les smartphones ? Communauté, documentation et version : Les plateformes sont-elles pérennes et dans quelles mesures pouvons-nous envisager leur avenir ? Performance : Toutes les plateformes sont-elles équivalentes en termes de réponse de calcul ? Temps de développement : Une plateforme apporte-t-elle plus d’avantages en termes de développement ? Coûts : Quels sont les coûts induits de chaque plateforme ? Interface graphique : Une plateforme apporte-t-elle une expérience utilisateur meilleure que les autres ? Lorsqu’un développement mobile est envisagé, il est important de bien définir les spécifications de l’application. Ainsi, on pourra évaluer l’importance des critères à l’aide d’une matrice de préférence. Par la suite, une matrice de décision nous indiquera la technologie la plus adaptée suivant le contexte

Therapeutic Efficacy of the Novel Stimuli-Sensitive Nano-Ferritins Containing Doxorubicin in a Head and Neck Cancer Model

Doxorubicin is employed alone or in combination for the treatment of several hematological and solid malignancies; despite its efficacy, there are associated cardiotoxicity limits both in its application in patients with heart disease risk factors and also in its long-term use. HFt-MP-PAS40 is a genetically engineered human ferritin heavy chain (HFt)-based construct able to efficiently entrap and deliver doxorubicin to cancer cells. HF-MP-PAS contains a short motif sequence (defined as MP) responsive to proteolytic cleavage by tumor matrix metalloproteases (MMPs), located between each HFt subunit and a masking polypeptide sequence rich in proline (P), alanine (A), and serine (S) residues (PAS). This carrier displayed excellent therapeutic efficacy in a xenogenic pancreatic cancer model in vivo, leading to a significant increase in overall animal survival in treated mice. Herein, we describe the HFt-MP-PAS40-Dox efficacy against squamous cell carcinomas of the head and neck (HNSCC) with the goal of validating the application of our nano-drug for the treatment of different solid tumors. In addition, a tolerability study in healthy mice was also performed. The results indicate that HFt-MP-PAS40-Dox produced increased anti-tumor effects both in vitro and in vivo in comparison to the free drug in several HNSCC cell lines. In the acute toxicity studies, the maximum tolerated dose (MTD) of HFt-MP-PAS40-Dox was about 3.5 higher than the free drug: 25 mg/kg versus 7 mg/kg doxorubicin equivalents. Importantly, evaluation of heart tissues provided evidence that doxorubicin is less cardio-toxic when encapsulated inside the ferritin carrier. In conclusion, HFt-MP-PAS40-Dox may be administered safely at higher doses compared with the free drug, resulting in superior efficacy to control HNSCC malignancies

Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles

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SNPs in DNA repair or oxidative stress genes and late subcutaneous fibrosis in patients following single shot partial breast irradiation

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of late toxicity studying our group of patients who underwent a Single Shot 3D-CRT PBI (SSPBI) after BCS (breast conserving surgery).</p> <p>Methods</p> <p>A total of 57 breast cancer patients who underwent SSPBI were genotyped for SNPs (single nucleotide polymorphisms) in XRCC1, XRCC3, GST and RAD51 by Pyrosequencing technology. Univariate analysis (ORs and 95% CI) was performed to correlate SNPs with the risk of developing ≥ G2 fibrosis or fat necrosis.</p> <p>Results</p> <p>A higher significant risk of developing ≥ G2 fibrosis or fat necrosis in patients with: polymorphic variant <it>GSTP1 </it>(Ile105Val) (OR = 2.9; 95%CI, 0.88-10.14, <it>p </it>= 0.047).</p> <p>Conclusions</p> <p>The presence of some SNPs involved in DNA repair or response to oxidative stress seem to be able to predict late toxicity.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01316328">NCT01316328</a></p

Categorization of Ambiguous Human/Ape Faces: Protection of Ingroup but Not Outgroup Humanity

In two studies, we tested the hypothesis that categorization of ambiguous human/ape faces depends on group membership: people are inclined to protect ingroup humanity, but not that of the outgroup. We used as stimuli: human, ape, ambiguous human/ape faces. Ambiguous human/ape faces were generated using a computerized morphing procedure. Participants categorized stimuli as human or ape. Two conditions were introduced: in the ingroup condition, participants were informed that human exemplars were ingroup members, in the outgroup condition that they were outgroup members. We expected participants, in an effort to protect ingroup humanity, to categorize ambiguous stimuli as ape more often in the ingroup than outgroup condition. Predictions were confi rmed. Results are discussed in the context of infrahumanization theory

Does status affect intergroup perceptions of humanity?

Across three studies, we examined whether ingroup status may affect intergroup perceptions of humanity. In Studies 1 and 2, we considered real groups: Northern versus Southern Italians; in Study 3, we manipulated the socioeconomic status of two minimal groups. In all studies, members of higher status groups perceived the ingroup as more human than the outgroup, while members of lower status groups did not assign a privileged human status to the ingroup. Such findings were obtained using different implicit techniques: the Implicit Association Test (IAT) and the Go/No-go Association Task (GNAT). Further, results suggest that the different perceptions of humanity may depend on the stereotypic traits generally ascribed to higher and lower status groups. The implications of results for infrahumanization research are discussed. © The Author(s) 2012

More competent than warm: The implicit stereotypes of Americans

Past research, based on explicit measures, has shown that Americans are rated as competent but not warm. In the present study, we assessed the implicit stereotype of Americans along the two dimensions of competence and warmth. Participants (Italian university students) completed a Go/No-go Association Task, in which Americans and Italians were the target categories and competence and warmth the target attributes. They also completed a questionnaire measuring three individual difference variables, namely Social Dominance Orientation, national identification, and political orientation. We hypothesized that Americans would be more associated with competence than warmth; we also expected Americans to be more associated with competence and less with warmth than Italians. Predictions were supported. The implicit associations were not correlated with the individual difference variables, thus suggesting they are a reflection of a well-learned cultural stereotype of Americans

More competent than warm: The implicit stereotypes of Americans.

Past research, based on explicit measures, has shown that Americans are rated as competent but not warm. In the present study, we assessed the implicit stereotype of Americans along the two dimensions of competence and warmth. Participants (Italian university students) completed a Go/No-go Association Task, in which Americans and Italians were the target categories and competence and warmth the target attributes. They also completed a questionnaire measuring three individual difference variables, namely Social Dominance Orientation, national identification, and political orientation. We hypothesized that Americans would be more associated with competence than warmth; we also expected Americans to be more associated with competence and less with warmth than Italians. Predictions were supported. The implicit associations were not correlated with the individual difference variables, thus suggesting they are a reflection of a well-learned cultural stereotype of Americans

More competent than warm: The implicit stereotypes of Americans

Past research, based on explicit measures, has shown that Americans are rated as competent but not warm. In the present study, we assessed the implicit stereotype of Americans along the two dimensions of competence and warmth. Participants (Italian university students) completed a Go/No-go Association Task, in which Americans and Italians were the target categories and competence and warmth the target attributes. They also completed a questionnaire measuring three individual difference variables, namely Social Dominance Orientation, national identification, and political orientation. We hypothesized that Americans would be more associated with competence than warmth; we also expected Americans to be more associated with competence and less with warmth than Italians. Predictions were supported. The implicit associations were not correlated with the individual difference variables, thus suggesting they are a reflection of a well-learned cultural stereotype of Americans

Individuals with intellectual and developmental disabilities: Do educators assign them a fully human status?

none5noThe present research investigates the humanity attributions to individuals with intellectual and developmental disabilities (IDD). In three studies, professional educators, who worked in day-care or community centers, were examined. Humanity attributions were assessed using emotion-based and trait-based measures. As expected, individuals with IDD were denied a fully human status: they were perceived as having more non-uniquely than uniquely human attributes. Furthermore, a lower human status was assigned to individuals with IDD in relation to educators. We also discovered that humanity attributions, but not attitudes, were related to approach/avoidance responses. Altogether, findings show the importance of considering humanity perceptions in the study of social relationships of individuals with IDD. Dehumanizing perceptions can explain the differential treatment these individuals face in various social settings.noneDora, Capozza; Antonio, Di Bernardo Gian; Rossella, Falvo; Renzo, Vianello; Luca, CalòCapozza, Dora; Antonio, Di Bernardo Gian; Falvo, Rossella; Vianello, Renzo; Calo', Luc