488 research outputs found
Directed Growth of Hydrogen Lines on Graphene: High Throughput Simulations Powered by Evolutionary Algorithm
We set up an evolutionary algorithm combined with density functional
tight-binding (DFTB) calculations to investigate hydrogen adsorption on flat
graphene and graphene monolayers curved over substrate steps. During the
evolution, candidates for the new generations are created by adsorption of an
additional hydrogen atom to the stable configurations of the previous
generation, where a mutation mechanism is also incorporated. Afterwards a
two-stage selection procedure is employed. Selected candidates act as the
parents of the next generation. In curved graphene, the evolution follows a
similar path except for a new mechanism, which aligns hydrogen atoms on the
line of minimum curvature. The mechanism is due to the increased chemical
reactivity of graphene along the minimum radius of curvature line (MRCL) and to
sp bond angles being commensurate with the kinked geometry of hydrogenated
graphene at the substrate edge. As a result, the reaction barrier is reduced
considerably along the MRCL, and hydrogenation continues like a mechanical
chain reaction. This growth mechanism enables lines of hydrogen atoms along the
MRCL, which has the potential to overcome substrate or rippling effects and
could make it possible to define edges or nanoribbons without actually cutting
the material.Comment: 10 pages of main text, 37 pages of supplementary information, 1
supplementary vide
Is Quantum Einstein Gravity Nonperturbatively Renormalizable?
We find considerable evidence supporting the conjecture that four-dimensional
Quantum Einstein Gravity is ``asymptotically safe'' in Weinberg's sense. This
would mean that the theory is likely to be nonperturbatively renormalizable and
thus could be considered a fundamental (rather than merely effective) theory
which is mathematically consistent and predictive down to arbitrarily small
length scales. For a truncated version of the exact flow equation of the
effective average action we establish the existence of a non-Gaussian
renormalization group fixed point which is suitable for the construction of a
nonperturbative infinite cutoff-limit. The truncation ansatz includes the
Einstein-Hilbert action and a higher derivative term.Comment: 18 pages, latex, 3 figure
The effective action and quantum gauge transformations
The local symmetry transformations of the quantum effective action for
general gauge theory are found. Additional symmetries arise under consideration
of background gauges. Together with "trivial" gauge transformations, vanishing
on mass shell, they can be used for construction simple gauge generators. For
example, for the Yang-Mills theory the classically invariant effective action
is obtained, reproducing DeWitt's result. For rank one theories a natural
generalization is proposed.Comment: Revtex, 11 pages; added reference
Casimir effect: running Newton constant or cosmological term
We argue that the instability of Euclidean Einstein gravity is an indication
that the vacuum is non perturbative and contains a condensate of the metric
tensor in a manner reminiscent of Yang-Mills theories. As a simple step toward
the characterization of such a vacuum the value of the one-loop effective
action is computed for Euclidean de Sitter spaces as a function of the
curvature when the unstable conformal modes are held fixed. Two phases are
found, one where the curvature is large and gravitons should be confined and
another one which appears to be weakly coupled and tends to be flat. The
induced cosmological constant is positive or negative in the strongly or weakly
curved phase, respectively. The relevance of the Casimir effect in
understanding the UV sensitivity of gravity is pointed out.Comment: Final, slightly extended version, to appear in Classical and Quantum
Gravit
The use of aortic balloon occlusion in traumatic shock : first report from the ABO trauma registry
Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a technique for temporary stabilization of patients with non-compressible torso hemorrhage. This technique has been increasingly used worldwide during the past decade. Despite the good outcomes of translational studies, clinical studies are divided. The aim of this multicenter-international study was to capture REBOA-specific data and outcomes. REBOA practicing centers were invited to join this online register, which was established in September 2014. REBOA cases were reported, both retrospective and prospective. Demographics, injury patterns, hemodynamic variables, REBOA-specific data, complications and 30-days mortality were reported. Ninety-six cases from 6 different countries were reported between 2011 and 2016. Mean age was 52 +/- 22 years and 88% of the cases were blunt trauma with a median injury severity score (ISS) of 41 (IQR 29-50). In the majority of the cases, Zone I REBOA was used. Median systolic blood pressure before balloon inflation was 60 mmHg (IQR 40-80), which increased to 100 mmHg (IQR 80-128) after inflation. Continuous occlusion was applied in 52% of the patients, and 48% received non-continuous occlusion. Occlusion time longer than 60 min was reported as 38 and 14% in the non-continuous and continuous groups, respectively. Complications, such as extremity compartment syndrome (n = 3), were only noted in the continuous occlusion group. The 30-day mortality for non-continuous REBOA was 48%, and 64% for continuous occlusion. This observational multicenter study presents results regarding continuous and non-continuous REBOA with favorable outcomes. However, further prospective studies are needed to be able to draw conclusions on morbidity and mortality.Peer reviewe
Bragg coherent x-ray diffractive imaging of a single indium phosphide nanowire
Three-dimensional (3D) Bragg coherent x-ray diffractive imaging (CXDI) with a nanofocused beam was applied to quantitatively map the internal strain field of a single indium phosphide nanowire. The quantitative values of the strain were obtained by pre-characterization of the beam profile with transmission ptychography on a test sample. Our measurements revealed the 3D strain distribution in a region of 150 nm below the catalyst Au particle. We observed a slight gradient of the strain in the range of ±0.6% along the [111] growth direction of the nanowire. We also determined the spatial resolution in our measurements to be about 10 nm in the direction perpendicular to the facets of the nanowire. The CXDI measurements were compared with the finite element method simulations and show a good agreement with our experimental results. The proposed approach can become an effective tool for in operando studies of the nanowires
Intravesicle Isothermal DNA Replication
<p>Abstract</p> <p>Background</p> <p>Bacterial and viral DNA replication was previously reconstituted <it>in vitro </it>from component parts <abbrgrp><abbr bid="B1">1</abbr><abbr bid="B2">2</abbr><abbr bid="B3">3</abbr><abbr bid="B4">4</abbr></abbrgrp>. Significant advances in building minimal cell-like structures also have been made recently <abbrgrp><abbr bid="B5">5</abbr><abbr bid="B6">6</abbr><abbr bid="B7">7</abbr></abbrgrp>. Combining the two approaches would further attempts to build a minimal cell-like structure capable of undergoing evolution by combining membrane encapsulation and genome replication. Towards this end, we attempted to use purified genomic replication protein components from thermophilic bacterial sources to copy strands of DNA isothermally within lipid vesicles.</p> <p>Findings</p> <p>Bacterial replication components (such as helicases and DNA polymerases) are compatible with methods for the generation of lipid vesicles. Encapsulation inside phospholipid vesicles does not inhibit the activity of bacterial DNA genome replication machinery. Further the described system is efficient at isothermally amplifying short segments of DNA within phospholipid vesicles.</p> <p>Conclusions</p> <p>Herein we show that bacterial isothermal DNA replication machinery is functional inside of phospholipid vesicles, suggesting that replicating cellular mimics can be built from purified bacterial components.</p
Renormalization and asymptotic safety in truncated quantum Einstein gravity
A perturbative quantum theory of the 2-Killing vector reduction of general
relativity is constructed. Although non-renormalizable in the standard sense,
we show that to all orders of the loop expansion strict cut-off independence
can be achieved in a space of Lagrangians differing only by a field dependent
conformal factor. In particular the Noether currents and the quantum
constraints can be defined as finite composite operators. The form of the field
dependence in the conformal factor changes with the renormalization scale and a
closed formula is obtained for the beta functional governing its flow. The flow
possesses a unique fixed point at which the trace anomaly is shown to vanish.
The approach to the fixed point adheres to Weinberg's ``asymptotic safety''
scenario, both in the gravitational wave/cosmological sector and in the
stationary sector.Comment: 67 pages, Latex; v3: improved discussion of stationary sector; agrees
with published versio
- …