Análisis comparativo de tres métodos de localización geográfica de las fuentes de atmosféricos

La localización geográfica de las descargas eléctricas en la atmósfera puede ser realizada mediante dos métodos básicos conocidos. Estos son, las triangulación radio-goniométrica y el método hiperbólico. Una tercera posibilidad consiste en implementar un método híbrido en el cual se utilizan simultáneamente los dos anteriores. El objeto de este trabajo consiste en analizar sucesivamente las posibilidades de cada uno de estos métodos, tanto desde el punto de vista de las precisiones alcanzables en la localización del punto de emisión, como de los medios e infraestructura necesarios para su puesta en funcionamiento. En base al análisis anterior, se extraen conclusiones a fin de seleccionar en cada caso la configuración óptima del sistema de localización.Geographic localization of the electric discharges in the atmosphere can be obtained using one of the two basic methods known. These are: radio -gonometric triangulation method or hyperbolic method. A third possibility could be the application of a hybrid method, applying the two above mentioned methods simultaneously. The object of this work consists in the successive analysis of the po ssibilities of these three methods from the point of view of exactness obtained in the localization of the emission, point as well as from the necessary means and organical structure to set each of them going. From the above mentioned analysis determinations can be taken so as to select in each case the most convenient localization system.Asociación Argentina de Geofísicos y Geodesta

Variación de las distribuciones espectrales de atmosféricos en función del umbral de recepción y del tiempo

La distribución estadística de las amplitudes espectrales de los atmosféricos puede ser considerada en el lugar de origen, como una logarítná co normal con suficiente aproximación. Por su parte, en una estación rece£ tora, distante de la fuente, aquella distribución se verá modificada en ma yor o menor medida por el camino de propagación, parámetros ionosféricos y terrestres y condiciones de recepción de las señales. En el presente trabajo analizamos la variación de los valores medios de las distribuciones espectrales en función del umbral de recepción de los equipos y del tiempo.The statistic distribution of atmospheric spectral amplitudes can be considered, in the original spot, as a normal logarithmic with sufficient approximation. At the same time, in a receiver station distant from the source, the above mentioned distribution will suffer modification in higher or lower scale depending on way of propagation, ionospheric and terre£ trial parameters and reception conditions of the signals. In this investigation work we analyze the variations of the average power of the spectral distributions regarding the reception threshold of the equipments and time.Asociación Argentina de Geofísicos y Geodesta

Variación de las distribuciones espectrales de atmosféricos en función del umbral de recepción y del tiempo

La distribución estadística de las amplitudes espectrales de los atmosféricos puede ser considerada en el lugar de origen, como una logarítná co normal con suficiente aproximación. Por su parte, en una estación rece£ tora, distante de la fuente, aquella distribución se verá modificada en ma yor o menor medida por el camino de propagación, parámetros ionosféricos y terrestres y condiciones de recepción de las señales. En el presente trabajo analizamos la variación de los valores medios de las distribuciones espectrales en función del umbral de recepción de los equipos y del tiempo.The statistic distribution of atmospheric spectral amplitudes can be considered, in the original spot, as a normal logarithmic with sufficient approximation. At the same time, in a receiver station distant from the source, the above mentioned distribution will suffer modification in higher or lower scale depending on way of propagation, ionospheric and terre£ trial parameters and reception conditions of the signals. In this investigation work we analyze the variations of the average power of the spectral distributions regarding the reception threshold of the equipments and time.Asociación Argentina de Geofísicos y Geodesta

Safety and efficacy of fluticasone propionate in the topical treatment of skin diseases

Fluticasone propionate - the first carbothioate corticosteroid - has been classified as a potent anti-inflammatory drug for dermatological use. It is available as 0.05% cream and 0.005% ointment formulations for the acute and maintenance treatment of patients with dermatological disorders such as atopic dermatitis, psoriasis and vitiligo. This glucocorticoid is characterized by high lipophilicity, high glucocorticoid receptor binding and activation, and a rapid metabolic turnover in skin. Although skin blanching following fluticasone propionate exceeds that of corticosteroids of medium strength, several clinical trials demonstrate a low potential for cutaneous and systemic side-effects, even in difficult-to-treat areas like the face, the eyelids and intertriginous areas. Even among paediatric patients with atopic dermatitis, fluticasone propionate proved to be safe and effective. These pharmacological and clinical properties are reflected by the high therapeutic index of this glucocorticoid

The presence of senescent peripheral T-cells is negatively correlated to COVID-19 vaccine-induced immunity in cancer patients under 70 years of age

PurposeCancer patients are at risk of severe COVID-19 infection, and vaccination is recommended. Nevertheless, we observe a failure of COVID-19 vaccines in this vulnerable population. We hypothesize that senescent peripheral T-cells alter COVID-19 vaccine-induced immunity.MethodsWe performed a monocentric prospective study and enrolled cancer patients and healthy donors before the COVID-19 vaccination. The primary objective was to assess the association of peripheral senescent T-cells (CD28-CD57+KLRG1+) with COVID-19 vaccine-induced immunity.ResultsEighty cancer patients have been included, with serological and specific T-cell responses evaluated before and at 3 months post-vaccination. Age ≥ 70 years was the principal clinical factor negatively influencing the serological (p=0.035) and specific SARS-CoV-2 T-cell responses (p=0.047). The presence of senescent T-cells was correlated to lower serological (p=0.049) and specific T-cell responses (p=0.009). Our results sustained the definition of a specific cut-off for senescence immune phenotype (SIP) (≥ 5% of CD4 and ≥ 39.5% of CD8 T-cells), which was correlated to a lower serological response induced by COVID-19 vaccination for CD4 and CD8 SIPhigh (p=0.039 and p=0.049 respectively). While CD4 SIP level had no impact on COVID-19 vaccine efficacy in elderly patients, our results unraveled a possible predictive role for CD4 SIPhigh T-cell levels in younger cancer patients.ConclusionsElderly cancer patients have a poor serological response to vaccination; specific strategies are needed in this population. Also, the presence of a CD4 SIPhigh affects the serological response in younger patients and seems to be a potential biomarker of no vaccinal response

Thymomectomy plus total thymectomy versus simple thymomectomy for early-stage thymoma without myasthenia gravis: A European Society of Thoracic Surgeons Thymic Working Group Study

OBJECTIVES: Resection of thymic tumours including the removal of both the tumour and the thymus gland (thymothymectomy; TT) is the procedure of choice and is recommended in most relevant articles in the literature. Nevertheless, in recent years, some authors have suggested that resection of the tumour (simple thymomectomy; ST) may suffice from an oncological standpoint in patients with early-stage thymoma who do not have myasthenia gravis (MG) (non-MG). The goal of our study was to compare the short-and long-term outcomes of ST versus TT in non-MG early-stage thymomas using the European Society of Thoracic Surgeons thymic database. METHODS: A total of 498 non-MG patients with pathological stage I thymoma were included in the study. TT was performed in 466 (93.6%) of 498 patients who had surgery with curative intent; ST was done in 32 (6.4%). The completeness of resection, the rate of complications, the 30-day mortality, the overall recurrence and the freedom from recurrence were compared. We performed crude and propensity score-adjusted comparisons by surgical approach (ST vs TT). RESULTS: TT showed the same rate of postoperative complications, 30-day mortality and postoperative length of stay as ST. The 5-year overall survival rate was 89% in the TT group and 55% in the ST group. The 5-year freedom from recurrence was 96% in the TT group and 79% in the ST group. CONCLUSION: Patients with early-stage thymoma without MG who have a TT show significantly better freedom from recurrence than those who have an ST, without an increase in postoperative morbidity rate