649 research outputs found
PReS-FINAL-2315: Severe cutaneous vasculitis in two patients with juvenile idiopathic arthritis and biologic therapy
Macrophage migration inhibitory factor gene polymorphisms in an Italian cohort of patients with Kawasaki disease
Bone mass and quality in patients with juvenile idiopathic arthritis: longitudinal evaluation of bone mass determinants using dual energy X-ray absorptiometry, peripheral quantitative computed tomography, and quantitative ultrasonography.
INTRODUCTION: Our objective was to evaluate longitudinally the main bone-mass and quality predictors in young juvenile idiopathic arthritis (JIA) patients by using lumbar spine dual-energy X-ray absorptiometry (DXA) scan, radius peripheral quantitative computed tomography (pQCT), and phalangeal quantitative ultrasonography (QUS) at the same time. METHODS: In total, 245 patients (172 females, 73 males; median age, 15.6 years: 148 oligoarticular, 55 polyarticular, 20 systemic, and 22 enthesitis-related-arthritis (ERA) onset) entered the study. Of these, 166 patients were evaluated longitudinally. Data were compared with two age- and sex-matched control groups. RESULTS: In comparison with controls, JIA patients, but not with ERA, had a reduced spine bone-mineral apparent density (BMAD) standard deviation score (P < 0.001) and musculoskeletal deficits, with significantly lower levels of trabecular bone mineral density (TrabBMD) (P < 0.0001), muscle cross-sectional area (CSA) (P < 0.005), and density-weighted polar section modulus (SSIp) (P < 0.05). In contrast, JIA showed fat CSA significantly higher than controls (P < 0.0001). Finally, JIA patients had a significant reduced amplitude-dependent speed of sound (AD-SoS) (P < 0.001), and QUS z score (P < 0.005). Longitudinally, we did not find any difference in all JIA patients in comparison with baseline, except for the SSIp value that normalized. Analyzing the treatments, a significant negative correlation among spine BMAD values, TrabBMD, AD-SoS, and systemic and/or intraarticular corticosteroids, and a positive correlation among TNF-α-blocking agents and spine BMAD, TrabBMD, and AD-SoS were observed. CONCLUSIONS: JIA patients have a low bone mass that, after a first increase due to the therapy, does not reach the normal condition over time. The pronounced bone deficits in JIA are greater than would be expected because of reduction in muscle cross-sectional area. Thus, bone alterations in JIA likely represent a mixed defect of bone accrual and lower muscle forces
GIANO-TNG spectroscopy of red supergiants in the young star cluster RSGC3
The Scutum complex in the inner disk of the Galaxy has a number of young star
clusters dominated by red supergiants that are heavily obscured by dust
extinction and observable only at infrared wavelengths. These clusters are
important tracers of the recent star formation and chemical enrichment history
in the inner Galaxy. During the technical commissioning and as a first science
verification of the GIANO spectrograph at the Telescopio Nazionale Galileo, we
secured high-resolution (R=50,000) near-infrared spectra of five red
supergiants in the young Scutum cluster RSGC3. Taking advantage of the full
YJHK spectral coverage of GIANO in a single exposure, we were able to measure
several tens of atomic and molecular lines that were suitable for determining
chemical abundances. By means of spectral synthesis and line equivalent width
measurements, we obtained abundances of Fe and iron-peak elements such as Ni,
Cr, and Cu, alpha (O, Mg, Si, Ca, Ti), other light elements (C, N, F, Na, Al,
and Sc), and some s-process elements (Y, Sr). We found average half-solar iron
abundances and solar-scaled [X/Fe] abundance patterns for most of the elements,
consistent with a thin-disk chemistry. We found depletion of [C/Fe] and
enhancement of [N/Fe], consistent with standard CN burning, and low 12C/13C
abundance ratios (between 9 and 11), which require extra-mixing processes in
the stellar interiors during the post-main sequence evolution. We also found
local standard of rest V(LSR)=106 km/s and heliocentric V(HEL)=90 km/s radial
velocities with a dispersion of 2.3 km/s. The inferred radial velocities,
abundances, and abundance patterns of RSGC3 are very similar to those
previously measured in the other two young clusters of the Scutum complex,
RSGC1 and RSGC2, suggesting a common kinematics and chemistry within the Scutum
complex
Lines and continuum sky emission in the near infrared: observational constraints from deep high spectral resolution spectra with GIANO-TNG
Aims Determining the intensity of lines and continuum airglow emission in the
H-band is important for the design of faint-object infrared spectrographs.
Existing spectra at low/medium resolution cannot disentangle the true
sky-continuum from instrumental effects (e.g. diffuse light in the wings of
strong lines). We aim to obtain, for the first time, a high resolution infrared
spectrum deep enough to set significant constraints on the continuum emission
between the lines in the H-band. Methods During the second commissioning run of
the GIANO high-resolution infrared spectrograph at La Palma Observatory, we
pointed the instrument directly to the sky and obtained a deep spectrum that
extends from 0.97 to 2.4 micron. Results The spectrum shows about 1500 emission
lines, a factor of two more than in previous works. Of these, 80% are
identified as OH transitions; half of these are from highly excited molecules
(hot-OH component) that are not included in the OH airglow emission models
normally used for astronomical applications. The other lines are attributable
to O2 or unidentified. Several of the faint lines are in spectral regions that
were previously believed to be free of line emission. The continuum in the
H-band is marginally detected at a level of about 300
photons/m^2/s/arcsec^2/micron, equivalent to 20.1 AB-mag/arcsec^2. The observed
spectrum and the list of observed sky-lines are published in electronic format.
Conclusions Our measurements indicate that the sky continuum in the H-band
could be even darker than previously believed. However, the myriad of airglow
emission lines severely limits the spectral ranges where very low background
can be effectively achieved with low/medium resolution spectrographs. We
identify a few spectral bands that could still remain quite dark at the
resolving power foreseen for VLT-MOONS (R ~6,600).Comment: 7 pages, 4 figures, to be published in Astronomy & Astrophysic
GIANO-TNG spectroscopy of red supergiants in the young star cluster RSGC2
The inner disk of the Galaxy has a number of young star clusters dominated by
red supergiants that are heavily obscured by dust extinction and observable
only at infrared wavelengths. These clusters are important tracers of the
recent star formation and chemical enrichment history in the inner Galaxy.
During the technical commissioning and as a first science verification of the
GIANO spectrograph at the Telescopio Nazionale Galileo, we secured
high-resolution (R~50,000) near-infrared spectra of three red supergiants in
the young Scutum cluster RSGC2. Taking advantage of the full YJHK spectral
coverage of GIANO in a single exposure, we were able to identify several tens
of atomic and molecular lines suitable for chemical abundance determinations.
By means of spectral synthesis and line equivalent width measurements, we
obtained abundances of Fe and other iron-peak elements such as V, Cr, Ni, of
alpha (O, Mg, Si, Ca and Ti) and other light elements (C, N, Na, Al, K, Sc),
and of some s-process elements (Y, Sr). We found iron abundances between half
and one third solar and solar-scaled [X/Fe] abundance patterns of iron-peak,
alpha and most of the light elements, consistent with a thin-disk chemistry. We
found a depletion of [C/Fe] and enhancement of [N/Fe], consistent with CN
burning, and low 12C/13C abundance ratios (between 9 and 11), requiring
extra-mixing processes in the stellar interiors during the post-main sequence
evolution. Finally, we found a slight [Sr/Fe] enhancement and a slight [Y/Fe]
depletion (by a factor of <=2), with respect to solar.Comment: Paper accepted on A&
Aspirin and colorectal cancer.
The relationship between aspirin use and colorectal cancer risk was examined by a case-control study in Italy. Regular aspirin use was reported by only 47 (3.5%) cases and 77 (4.1%) control subjects, giving a multivariate odds ratio (OR) of 0.7 (95% CI 0.5-1.0) after allowance for education, physical exercise and selected dietary factors
Arthritis as a presenting feature of non-Hodgkin’s lymphoma
Leukaemia can present with joint swelling in the absence of abnormal haematological findings. Arthritis as a presenting sign of lymphoma, however, is extremely rare. Three children with non-Hodgkin's lymphoma who had joint swelling at the onset of their disease are reported. Two cases showed histological features of anaplastic large cell lymphoma (Ki-1/CD30 positive), and one of angioimmunoblastic T cell lymphoma. In all patients the unusual presentation delayed correct diagnosis
The fiber-fed preslit of GIANO at T.N.G
Giano is a Cryogenic Spectrograph located in T.N.G. (Spain) and commisioned
in 2013. It works in the range 950-2500 nm with a resolving power of 50000.
This instrument was designed and built for direct feeding from the telescope
[2]. However, due to constraints imposed on the telescope interfacing during
the pre-commissioning phase, it had to be positioned on the rotating building,
far from the telescope focus. Therefore, a new interface to the telescope,
based on IR-transmitting ZBLAN fibers with 85\mu m core, was
developed.Originally designed to work directly at the nasmyth focus of
the telescope, in 2011 it has decided to use a fiber to feed it. The beam from
the telescope is focused on a double fiber boundle by a Preslit Optical Bench
attached to the Nasmith A interface of the telescope. This Optical Bench
contains the fiber feeding system and other important features as a guiding
system, a fiber viewer, a fiber feed calibration lamp and a nodding facility
between the two fibers. The use of two fibers allow us to have in the
echellogram two spectrograms side by side in the same acquisition: one of the
star and the other of the sky or simultaneously to have the star and a
calibration lamp. Before entering the cryostat the light from the fiber is
collectd by a second Preslit Optical Bench attached directly to the Giano
cryostat: on this bench the correct f-number to illuminate the cold stop is
generated and on the same bench is placed an image slicer to increase the
efficiency of the system.Comment: 21 pages, 24 figures, 3 tables. Presented at SPIE Astronomical
Telescope + Instrumentation 2014 (Ground-based and Airbone Instrumentation
for Astronomy 5, 9147-360). To be published in Proceeding of SPIE Volume 914
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