Cimaz, R

Corinaldesi, E

De Martino, M

Falcini, F

Massai, C

Simonini, G

Pediatric Rheumatology

English

PubMed

G Simonini

E Corinaldesi

F Falcini

C Massai

M De Martino

R Cimaz

Springer - Publisher Connector

BioMed Central
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Pediatric Rheumatology
Open AccessPoster presentation
Macrophage migration inhibitory factor gene polymorphisms in an 
Italian cohort of patients with Kawasaki disease
G Simonini*, E Corinaldesi, F Falcini, C Massai, M De Martino and R Cimaz
Address: A Meyer Children's Hospital, Florence, Italy
* Corresponding author    
Background
MIF (macrophage migration inhibitory factor) is a proin-
flammatory cytokine regulator of host inflammatory and
immune responses, and is expressed by many different
cells types. Serum levels of MIF have been found to be
increased in several inflammatory diseases, Kawasaki dis-
ease (KD) included.
Objective
To evaluate possible differences in MIF polymorphisms
between patients with KD and healthy subjects, and
between KD patients with and without coronary altera-
tions. Methods. We screened for the MIF gene polymorf-
isms -173 a group of 69 patients discharged from our
hospital with a diagnosis of Kawasaki disease and 60
healthy controls.
Results
The average age at disease onset was 29 months (range, 3–
135 months). There were 43 females (33.3%) and 26
(20.2%) males. Eight children (12%) were non-respond-
ers to the first IVIG infusion. Nine children (13%) had
coronary alterations (ectasia or aneurysms). Statistical
analysis for MIF genotyping did not show significant dif-
ferences between patients and controls, both for allelic
and genotypic frequencies. However KD patients carrying
a MIF -173*C allele developed CAA more frequently than
those without these alleles (7/9 77.8% vs 16/44 26.7%, p
< 0.005) and the MIF -173*CC homozygosis resulted
more frequent in children with CAA than those without
(2/9 CC 22.2% vs 2/60 CC: 3.3%, p < 0.004). Moreover,
non-responders to a single IVIG infusion carried the MIF -
173*C allele more frequently than responders (6/8 = 75%
vs 17/61 = 28%, p < 0.014).
Conclusion
Our study suggest a potential relationship between a MIF
polymorphism and risk of CAA in KD.
from 15th Paediatric Rheumatology European Society (PreS) Congress
London, UK. 14–17 September 2008
Published: 15 September 2008
Pediatric Rheumatology 2008, 6(Suppl 1):P256 doi:10.1186/1546-0096-6-S1-P256
<supplement> <title> <p>15<sup>th </sup>Paediatric Rheumatology European Society (PreS) Congress</p> </title> <editor>Wietse Kuis, Patricia Woo, Angelo Ravelli, Hermann Girschick, Michaël Hofer, Johannes Roth, Rotraud K Saurenmann, Alberto Martini, Pavla Dolezova, Janjaap van der Net, Pierre Quartier, Lucy Wedderburn and Jan Scott</editor> <note>Meeting abstracts – A single PDF containing all abstracts in this Supplement is available <a href="http://www.biomedcentral.com/content/files/PDF/1546-0096-6-S1-full.pdf">here</a>.</note> </supplement>
This abstract is available from: http://www.ped-rheum.com/content/6/S1/P256
© 2008 Simonini et al; licensee BioMed Central Ltd. 


Macrophage migration inhibitory factor gene polymorphisms in an Italian cohort of patients with Kawasaki disease

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Macrophage migration inhibitory factor gene polymorphisms in an Italian cohort of patients with Kawasaki disease

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