Helium identification with LHCb

The identification of helium nuclei at LHCb is achieved using a method based on measurements of ionisation losses in the silicon sensors and timing measurements in the Outer Tracker drift tubes. The background from photon conversions is reduced using the RICH detectors and an isolation requirement. The method is developed using pp collision data at √(s) = 13 TeV recorded by the LHCb experiment in the years 2016 to 2018, corresponding to an integrated luminosity of 5.5 fb-1. A total of around 105 helium and antihelium candidates are identified with negligible background contamination. The helium identification efficiency is estimated to be approximately 50% with a corresponding background rejection rate of up to O(10^12). These results demonstrate the feasibility of a rich programme of measurements of QCD and astrophysics interest involving light nuclei

Measurement of forward charged hadron flow harmonics in peripheral PbPb collisions at √sNN = 5.02 TeV with the LHCb detector

Flow harmonic coefficients, v n , which are the key to studying the hydrodynamics of the quark-gluon plasma (QGP) created in heavy-ion collisions, have been measured in various collision systems and kinematic regions and using various particle species. The study of flow harmonics in a wide pseudorapidity range is particularly valuable to understand the temperature dependence of the shear viscosity to entropy density ratio of the QGP. This paper presents the first LHCb results of the second- and the third-order flow harmonic coefficients of charged hadrons as a function of transverse momentum in the forward region, corresponding to pseudorapidities between 2.0 and 4.9, using the data collected from PbPb collisions in 2018 at a center-of-mass energy of 5.02 TeV . The coefficients measured using the two-particle angular correlation analysis method are smaller than the central-pseudorapidity measurements at ALICE and ATLAS from the same collision system but share similar features

Curvature-bias corrections using a pseudomass method

Momentum measurements for very high momentum charged particles, such as muons from electroweak vector boson decays, are particularly susceptible to charge-dependent curvature biases that arise from misalignments of tracking detectors. Low momentum charged particles used in alignment procedures have limited sensitivity to coherent displacements of such detectors, and therefore are unable to fully constrain these misalignments to the precision necessary for studies of electroweak physics. Additional approaches are therefore required to understand and correct for these effects. In this paper the curvature biases present at the LHCb detector are studied using the pseudomass method in proton-proton collision data recorded at centre of mass energy √(s)=13 TeV during 2016, 2017 and 2018. The biases are determined using Z→μ + μ - decays in intervals defined by the data-taking period, magnet polarity and muon direction. Correcting for these biases, which are typically at the 10-4 GeV-1 level, improves the Z→μ + μ - mass resolution by roughly 18% and eliminates several pathological trends in the kinematic-dependence of the mean dimuon invariant mass

Multiple Organ Failure In Septic Patients.

Multiple organ failure (MOF) is the main cause of death in ICUs, especially affecting septic patients. It is strongly related to number of systems with failure, type of system involved, risk factors such as age, previous chronic diseases, delayed or inadequate resuscitation, persistent infection, immune suppression, and others. The prognoses is worse for patients rather than in elective or emergency surgical patients. The objective of this article is to provide data from our university teaching hospital ICU related to the incidence of septic patients, the distribution of MOF, and distribution of failure among each of the organs. The mortality rate, relationship between mortality and age, and mortality and types of organs affected were evaluated. The main bacterial causes of sepsis were also identified. A retrospective evaluation was done of 249 patients admitted to the ICU in a 4 month period during 1999. Fifty four patients had sepsis diagnosed by ACCS/SCCM criteria. There were 37 men and 17 women; 24 medical and 30 post-surgical patients (9 after elective surgery and 21 emergency patients). APACHE II score was calculated on admission and MOF, measured for the first five days, was diagnosed using Marshall and Meakins criteria. The statistical method used was non-parametric Mann-Whitney test, p61 years 13/19 (68%), died. There were 23 patients with positive bacterial culture. The most frequent bacteria found were: Pseudomonas aeruginosa (5), multiresistant Acinetobacter baumanii (3), Staphylococcus epidermidis (3), Enterobacter aerogenes (3), Klebsiella pneumoniae (2) and multiresistant Staphylococcus aureus (2). The mean value +/- SD of APACHE II (mortality risk) for survivors was 21 +/- 18 and for non-survivors 42 +/- 26 (p<0.001). We conclude that MOF due to sepsis in an ICU is frequent, with high mortality related to the number of failing organs, age and high APACHE II.5310311

Highlighting Intracranial Pressure Monitoring In Patients With Severe Acute Brain Trauma.

Intracranial pressure (ICP) monitoring was carried out in 100 patients with severe acute brain trauma, primarily by means of a subarachnoid catheter. Statistical associations were evaluated between maximum ICP values and: 1) Glasgow Coma Scale (GCS) scores; 2) findings on computed tomography (CT) scans of the head; and 3) mortality. A significant association was found between low GCS scores (3 to 5) and high ICP levels, as well as between focal lesions on CT scans and elevated ICP. Mortality was significantly higher in patients with ICP > 40 mm Hg than in those with ICP < or = 20 mm Hg.533 A39039

Relations Between Memory Complaints, Depressive Symptoms And Cognitive Performance Among Community Dwelling Elderly [relações Entre Queixas De Memória, Sintomas Depressivos E Desempenho Cognitivo Em Idosos Residentes Na Comunidade]

Background: Memory complaints are quite common among the elderly; yet, the clinical relevance of these complaints to diagnose cognitive decline is debatable, since several different factors could be associated with them. Objective: The present paper examined the correlations between memory complaints, depressive symptoms and cognitive performance in a group of 301 elderly individuals who lived in the district of Ermelino Matarazzo, São Paulo, and who participated in the population-based survey entitled Profiles of Frailty in Elderly Brazilians by the FIBRA Network. Methods: Cognitive performance was assessed with the memorization test involving 10 common pictures, the Mini Mental State Examination (MMSE), the Verbal Fluency (VF) test, and the Clock Drawing Test, which comprise the Brief Cognitive Screening Battery (BCSB). Memory complaints were assessed with the Memory Complaint Questionnaire (MAC-Q), and depressive symptoms with the Geriatric Depression Scale (GDS). Results: Female participants had higher rates of memory complaints when compared to male participants (p = 0.013). Subjects with less years of schooling had more severe memory complaints and poorer cognitive performance than those with more years of schooling (p < 0.003). Te presence of depressive symptoms was associated with poorer memory assessment scores (r = 0.39, p < 0.001). Discussion: Memory complaints were correlated with sex, schooling and depressive symptoms among elderly individuals residing in the community. No correlation was found between complaints and cognitive performance.4136771Berry, J.M., West, R.L., Dennehey, D.M., Reliability and validity of the memory self-efficacy questionnaire (1998) Develop Psychol, 25, pp. 701-713Cavanaugh, J.C., Poon, L.W., Metamemorial predictors of memory performance in young and older adults (1989) Psychol Aging, 4 (3), pp. 215-227Cavanaugh, J.C., Green, E.E., I believe, therefore I can: Self-efficacy beliefs in memory aging (1990) Aging and Cognition: Mental Processes, Self-awareness, and Interventions, pp. 189-230. , In: Lovelace EA, editor, Amsterdam: ElsevierYassuda, M.S., Lasca, V.B., Neri, A.L., Metamemória e autoefcácia em instru-mentos de pesquisa (2005) Psicol Refex Crít, 18 (1), pp. 78-90Comissaris, C.J., Ponds, R.W., Jolles, J., Subjective forgetfulness in a normal Dutch population: Possibilities for health education and other interventions (1998) Patient Educ Couns, 34 (1), pp. 25-32Izquierdo, I., (2002) Memória, , Porto Alegre: ArtmedBolla, K.I., Lindgren, K.N., Bonaccorsy, C., Bleecker, M.L., Memory complaints in older adults. Fact or fiction? (1991) Arch Neurol, 48 (1), pp. 61-64Allegri, F.R., Harris, P., Serrano, C., Delavald, N., Perfs diferenciais de perda de memória entre demência frontotemporal e do tipo Alzheimer (2001) Psicol Refex Crít, 14 (2), pp. 317-324Albert, M.S., Dekosky, S.T., Dickson, D., Dubois, B., Feldman, H.H., Fox, N.C., The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging and Alzheimer's Association workgroup (2011) Alzheimers Dement, 7 (3), pp. 1-10Frota, N.A.F., Nitrini, R., Damasceno, B.P., Forlenza, O.V., Dias-Tosta, E., Silva, A.B., Group Recommendations in Alzheimer's Disease and Vascular Dementia of the Brazilian Academy of Neurology. Criteria for the diagnosis of Alzheimer's disease (2011) Dement Neuropsychol, 5 (3), pp. 146-152Charchat-Fichman, H., Caramelli, P., Sameshima, K., Nitrini, R., Declínio da capacidade cognitiva durante o envelhecimento (2005) Rev Bras Psiquiatr, 27 (12), pp. 79-82Brucki, S.M.D., Envelhecimento e memória Neuropsicologia Hoje, p. 2004. , Andrade VM, Bueno OFA, Santos FH, editores, São Paulo: Artes MédicasMattos, P., Lino, V., Rizo, L., Alfano, A., Araújo, C., Raggio, R., Memory complaints and test performance in healthy elderly persons (2003) Arq Neuro--Psiquiatr, 61 (4), pp. 920-924Lima-Silva, T.B., Yassuda, M.S., The relationship between memory com plaints and age in normal aging (2009) Dement Neuropsychol, 3 (2), pp. 94-100Xavier, F., Ferraz, M.P.T., Gil, O.F., Moriguchi, E.H., Queixa subjetiva de perda de memória no idoso: Uma comparação da percepção dos sujeitos com a percepção dos familiares em um estudo na comunidade (1999) Rev Bras Neurol, 35 (5), pp. 137-141Parisi, J.M., Gross, A.L., Rebok, G.W., Saczynski, J.S., Crowe, M., Cook, S.E., Modeling change in memory performance and memory perceptions: Findings from the ACTIVE study (2011) Psychol Aging, 26 (3), pp. 518-524van Oijen, M., Jong, F.J., Hofman, A., Koudstaal, P.J., Breteler, M.M., Subjective memory complaints, education, and risk of Alzheimer's disease (2007) Alzhei-mers Dement, 3 (2), pp. 92-97Waldorf, F.B., Siersma, V., Vogel, A., Waldemar, G., Subjective memory complaints in general practice predicts future dementia: A 4-year follow-up study (2012) Int J Geriatr Psychiatry, 27 (11), pp. 1180-1188Jonker, C., Geerlings, M.I., Schmand, B., Are memory complaints predictive for dementia? A review of clinical and population-based studies (2000) Int J Geriatr Psychiatry, 15 (11), pp. 983-991Nitrini, R., Caramelli, P., Herrera, E., Porto, C.S., Charchat-Fichman, H., Carthery, M.T., Performance of illiterate and literate nondemented elderly subjects in two tests of long-term memory (2004) J Int Neuropsychol Soc, 10 (4), pp. 634-638Vitiello, A.P.P., Ciríaco, J.G.M., Takahashi, D.Y., Nitrini, R., Caramelli, P., Avalia-ção cognitiva breve de pacientes atendidos em ambulatório de neurologia geral (2007) Arq Neuropsiquiatr, 65 (2 A), pp. 299-303Schofeld, P.W., Marder, K., Dooneref, G., Jacobs, M.S., Sano, M., Stein, Y., Association of subjective memory complaints with subsequent cognitive decline in community-dwelling elderly individuals with baseline cognitive impairment (1997) Am J Psychiatry, 54 (5), pp. 609-615Cook, S., Marsiske, M., Subjective memory beliefs and cognitive performance in normal and mildly impaired older adults (2006) Aging Ment Health, 10 (4), pp. 413-423Neri, A.L., Yassuda, M.S., de Araújo, L.F., Eulálio, M.C., Cabral, B.E., de Siqueira, M.E., Methodology and social, demographic, cognitive, and frailty profiles of community-dwelling elderly from seven Brazilian cities: The FIBRA Study (2013) Cad. 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Gastroprotective Effect Of The Ethanolic Extract And Fractions Obtained From Syngonanthus Bisulcatus Rul

Syngonanthus bisulcatus Rul., popularly known in Brazil as "sempre-vivas chapadeira", is a plant of the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. In this work, the ethanolic extract (EtOHE), flavonoid-rich (FRF), and flavonoid-deficient (FDF) fractions obtained from scapes of S. bisulcatus were investigated for gastroprotection in both rats and mice. The activity was evaluated in models for induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation). The participation of mucus and prostaglandin E2 were also investigated. Sb-EtOHE (50, 100, and 250 mg/kg, p.o.), Sb-FRF (100 mg/kg, p.o.), and Sb-FDF (100 mg/kg, p.o.) significantly reduced gastric injuries in all models. Sb-FRF altered gastric juice parameters after pylorus ligation. Sb-FRF and Sb-FDF (100 mg/kg each, p.o.) significantly increased the amount of adherent mucus in the gastric mucosa. Sb-FRF maintained the mucosal levels of prostaglandin after the administration of indomethacin. The results indicate that Sb-EtOHE, Sb-FRF and Sb-FDF have significant gastroprotective activity. 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Gastroprotective Mechanisms Of The Chloroform And Ethyl Acetate Phases Of Praxelis Clematidea (griseb.) R.m.king & H.robinson (asteraceae)

Flavonoid-rich Praxelis clematidea (Griseb.) R.M.King &amp; H.Robinson (Asteraceae) is a native plant of South America. This study evaluates the gastroprotective activity and possible mechanisms for both the chloroform (CHCl3P) and ethyl acetate phases (AcOEtP) obtained from aerial parts of the plant. The activity was investigated using acute models of gastric ulcer. Gastric secretion biochemical parameters were determined after pylorus ligature. The participation of cytoprotective factors such as mucus, nitric oxide (NO), sulfhydryl (SH) groups, prostaglandin E2 (PGE 2), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), reduction of lipid peroxidation (malondialdehyde level), and polymorphonuclear infiltration (myeloperoxidase activity), was also investigated. CHCl3P (125, 250, and 500 mg/kg) and AcOEtP (62.5, 125, and 250 mg/kg) showed significant gastroprotective activity, reducing the ulcerative index by 75, 83, 88 % and 66, 66, 81 % for ethanol; 67, 67, 56 % and 56, 53, 58 % for a non-steroidal anti-inflammatory drug (NSAID); and 74, 58, 59 % and 64, 65, 61 % for stress-induced gastric ulcer, respectively. CHCl3P (125 mg/kg) and AcOEtP (62.5 mg/kg) significantly reduced the ulcerative area by 78 and 83 %, respectively, for the ischemia-reperfusion model. They also did not alter the biochemical parameters of gastric secretion, the GSH level or the activities of SOD, GPx or GR. They increased the quantity of gastric mucus, not dependent on NO, yet dependent on SH groups, and maintained PGE2 levels. 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